File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Meta-analysis suggests that smoking is associated with an increased risk of early natural menopause

TitleMeta-analysis suggests that smoking is associated with an increased risk of early natural menopause
Authors
KeywordsAge at natural menopause
Meta-analysis
Smoking
Issue Date2012
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.com
Citation
Menopause, 2012, v. 19 n. 2, p. 126-132 How to Cite?
AbstractObjective: Age at natural menopause (ANM) is usually defined as the age at the last menstrual bleeding followed by the absence of menses for 12 consecutive months. Although many studies have suggested an association between smoking and early age at natural menopause, evidence remains conflicting because some studies reported inconsistent or contrasting results. To resolve this ambiguity and to quantitatively evaluate the effect of smoking on ANM, we conducted a meta-analysis of the available data about smoking and ANM. Methods: After extensive searching of public literature databases, a total of 11 studies were selected for this meta-analysis. Among them, the phenotype of the participants in five studies (dichotomous studies) was classified as early or late ANM, and odds ratio (OR) was used to evaluate the effect of smoking on early ANM. For the other six studies (continuous studies), mean and SD were provided for smoking and nonsmoking samples, and weighted mean difference (WMD) was used as the effect size. Results: We found that smoking was significantly associated with early ANM in both dichotomous and continuous studies. The pooled effect was OR = 0.74 (95% CI, 0.60-0.91, P < 0.01) in the dichotomous studies. For the continuous studies, the pooled effect estimated by WMD was-1.12 (95% CI,-1.80 to-0.44, P = 0.04). After adjustment of the original data for heterogeneity, the pooled results changed only a little: OR = 0.67 (95% CI, 0.61-0.73, P < 0.01) for dichotomous studies and WMD =-0.90 (95% CI,-1.58 to-0.21, P = 0.01) for the continuous studies. Conclusions: The results of our study suggest that smoking is a significant independent factor for early ANM. © 2012 The North American Menopause Society.
Persistent Identifierhttp://hdl.handle.net/10722/145621
ISSN
2015 Impact Factor: 3.172
2015 SCImago Journal Rankings: 1.270
ISI Accession Number ID
Funding AgencyGrant Number
Natural Science Foundation of China (NSFC)30900810
30771222
31071097
30600364
NSFC-Canadian Institutes of Health Research (CIHR) Joint Health Research Initiative Proposal30811120436
University of Hong Kong
Funding Information:

The study was supported by the Natural Science Foundation of China (NSFC; 30900810, 30771222, 31071097, 30600364), the NSFC-Canadian Institutes of Health Research (CIHR) Joint Health Research Initiative Proposal (30811120436), and the University of Hong Kong startup fund (to Volodymyr Dvornyk).

References

 

DC FieldValueLanguage
dc.contributor.authorSun, Len_HK
dc.contributor.authorTan, Len_HK
dc.contributor.authorYang, Fen_HK
dc.contributor.authorLuo, Yen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorDeng, HWen_HK
dc.contributor.authorDvornyk, Ven_HK
dc.date.accessioned2012-02-28T01:58:39Z-
dc.date.available2012-02-28T01:58:39Z-
dc.date.issued2012en_HK
dc.identifier.citationMenopause, 2012, v. 19 n. 2, p. 126-132en_HK
dc.identifier.issn1072-3714en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145621-
dc.description.abstractObjective: Age at natural menopause (ANM) is usually defined as the age at the last menstrual bleeding followed by the absence of menses for 12 consecutive months. Although many studies have suggested an association between smoking and early age at natural menopause, evidence remains conflicting because some studies reported inconsistent or contrasting results. To resolve this ambiguity and to quantitatively evaluate the effect of smoking on ANM, we conducted a meta-analysis of the available data about smoking and ANM. Methods: After extensive searching of public literature databases, a total of 11 studies were selected for this meta-analysis. Among them, the phenotype of the participants in five studies (dichotomous studies) was classified as early or late ANM, and odds ratio (OR) was used to evaluate the effect of smoking on early ANM. For the other six studies (continuous studies), mean and SD were provided for smoking and nonsmoking samples, and weighted mean difference (WMD) was used as the effect size. Results: We found that smoking was significantly associated with early ANM in both dichotomous and continuous studies. The pooled effect was OR = 0.74 (95% CI, 0.60-0.91, P < 0.01) in the dichotomous studies. For the continuous studies, the pooled effect estimated by WMD was-1.12 (95% CI,-1.80 to-0.44, P = 0.04). After adjustment of the original data for heterogeneity, the pooled results changed only a little: OR = 0.67 (95% CI, 0.61-0.73, P < 0.01) for dichotomous studies and WMD =-0.90 (95% CI,-1.58 to-0.21, P = 0.01) for the continuous studies. Conclusions: The results of our study suggest that smoking is a significant independent factor for early ANM. © 2012 The North American Menopause Society.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.comen_HK
dc.relation.ispartofMenopauseen_HK
dc.subjectAge at natural menopauseen_HK
dc.subjectMeta-analysisen_HK
dc.subjectSmokingen_HK
dc.subject.meshAge Factors-
dc.subject.meshBias (Epidemiology)-
dc.subject.meshMenopause-
dc.subject.meshPhenotype-
dc.subject.meshSmoking - adverse effects-
dc.titleMeta-analysis suggests that smoking is associated with an increased risk of early natural menopauseen_HK
dc.typeArticleen_HK
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_HK
dc.identifier.authorityDvornyk, V=rp00693en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/gme.0b013e318224f9acen_HK
dc.identifier.pmid21946090-
dc.identifier.scopuseid_2-s2.0-84856511162en_HK
dc.identifier.hkuros198694en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856511162&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue2en_HK
dc.identifier.spage126en_HK
dc.identifier.epage132en_HK
dc.identifier.isiWOS:000300025800005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSun, L=7403957441en_HK
dc.identifier.scopusauthoridTan, L=15133198200en_HK
dc.identifier.scopusauthoridYang, F=7403450091en_HK
dc.identifier.scopusauthoridLuo, Y=51565764300en_HK
dc.identifier.scopusauthoridLi, X=51565697300en_HK
dc.identifier.scopusauthoridDeng, HW=7401775190en_HK
dc.identifier.scopusauthoridDvornyk, V=6701789786en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats