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Article: Association analyses suggest the effects of RANK and RANKL on age at menarche in Chinese women.

TitleAssociation analyses suggest the effects of RANK and RANKL on age at menarche in Chinese women.
Authors
Issue Date2012
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13697137.asp
Citation
Climacteric : The Journal Of The International Menopause Society, 2012, v. 15 n. 1, p. 75-81 How to Cite?
AbstractAge at menarche (AAM), the time of the first menstrual bleeding, is an important developmental milestone in the female life. It marks the beginning of the reproductive period. AAM is implicated in the risk of many health complications in later life. In this study, we conducted an analysis for association of single nucleotide polymorphisms (SNPs) and common haplotypes of two candidate genes, RANK (receptor activator of the NF-κB) and RANKL (receptor activator of the NF-κB ligand), with AAM in 825 unrelated Chinese women. In total, 73 SNPs of RANKL and 23 SNPs of RANK were genotyped. The SNPs and common haplotypes were then analyzed for their association with AAM. Age and age( 2 ) were used as covariates. We found five individual SNPs (rs7239261, rs8094884, rs3826620, rs8089829, and rs9956850) of RANK significantly associated with AAM (p < 0.05). Although no significant association was identified for the RANKL gene, three polymorphisms showed nearly significant (0.05 < p < 0.08) association with AAM. Seven haplotypes of RANK were significantly associated with AAM (p < 0.05); the most significant association of the AT haplotype composed by rs1805034 and rs4524034 (p = 9.4 × 10(-4)) remained significant (p = 0.0235) after the Bonferroni correction for multiple testing. Three haplotypes of RANKL were significantly associated with AAM (p < 0.05). Importantly, the association of rs3826620 replicated our previous findings for Caucasian females. The results of the present study suggest that the RANK and RANKL are two candidate genes for AAM in Chinese women.
Persistent Identifierhttp://hdl.handle.net/10722/145620
ISSN
2015 SCImago Journal Rankings: 0.723
ISI Accession Number ID
Funding AgencyGrant Number
NIHR01 AR050496-01
R21 AG027110
R01 AG026564
P50 AR055081
Hunan Normal University
University of Hong Kong
Funding Information:

Investigators in this work were partially supported by grants from NIH (R01 AR050496-01, R21 AG027110, R01 AG026564, and P50 AR055081). The study also benefited from 211 State Key Research Fund by Hunan Normal University and the University of Hong Kong start-up fund (to V.D.).

 

DC FieldValueLanguage
dc.contributor.authorPan, Ren_HK
dc.contributor.authorLiu, YZen_HK
dc.contributor.authorDeng, HWen_HK
dc.contributor.authorDvornyk, Ven_HK
dc.date.accessioned2012-02-28T01:58:39Z-
dc.date.available2012-02-28T01:58:39Z-
dc.date.issued2012en_HK
dc.identifier.citationClimacteric : The Journal Of The International Menopause Society, 2012, v. 15 n. 1, p. 75-81en_HK
dc.identifier.issn1473-0804en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145620-
dc.description.abstractAge at menarche (AAM), the time of the first menstrual bleeding, is an important developmental milestone in the female life. It marks the beginning of the reproductive period. AAM is implicated in the risk of many health complications in later life. In this study, we conducted an analysis for association of single nucleotide polymorphisms (SNPs) and common haplotypes of two candidate genes, RANK (receptor activator of the NF-κB) and RANKL (receptor activator of the NF-κB ligand), with AAM in 825 unrelated Chinese women. In total, 73 SNPs of RANKL and 23 SNPs of RANK were genotyped. The SNPs and common haplotypes were then analyzed for their association with AAM. Age and age( 2 ) were used as covariates. We found five individual SNPs (rs7239261, rs8094884, rs3826620, rs8089829, and rs9956850) of RANK significantly associated with AAM (p < 0.05). Although no significant association was identified for the RANKL gene, three polymorphisms showed nearly significant (0.05 < p < 0.08) association with AAM. Seven haplotypes of RANK were significantly associated with AAM (p < 0.05); the most significant association of the AT haplotype composed by rs1805034 and rs4524034 (p = 9.4 × 10(-4)) remained significant (p = 0.0235) after the Bonferroni correction for multiple testing. Three haplotypes of RANKL were significantly associated with AAM (p < 0.05). Importantly, the association of rs3826620 replicated our previous findings for Caucasian females. The results of the present study suggest that the RANK and RANKL are two candidate genes for AAM in Chinese women.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13697137.aspen_US
dc.relation.ispartofClimacteric : the journal of the International Menopause Societyen_HK
dc.rightsClimacteric. Copyright © Informa Healthcare.en_US
dc.subject.meshAsian Continental Ancestry Group-
dc.subject.meshMenarche - ethnology - genetics-
dc.subject.meshRANK Ligand - genetics-
dc.subject.meshReproduction - genetics-
dc.subject.meshSexual Development - genetics-
dc.titleAssociation analyses suggest the effects of RANK and RANKL on age at menarche in Chinese women.en_HK
dc.typeArticleen_HK
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_HK
dc.identifier.authorityDvornyk, V=rp00693en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/13697137.2011.587556en_HK
dc.identifier.pmid22023082-
dc.identifier.scopuseid_2-s2.0-84860333426en_HK
dc.identifier.hkuros198693en_US
dc.identifier.volume15en_HK
dc.identifier.issue1en_HK
dc.identifier.spage75en_HK
dc.identifier.epage81en_HK
dc.identifier.isiWOS:000298927600012-
dc.publisher.placeUnited Kingdom-
dc.identifier.scopusauthoridPan, R=55200505400en_HK
dc.identifier.scopusauthoridLiu, YZ=55200937200en_HK
dc.identifier.scopusauthoridDeng, HW=7401775190en_HK
dc.identifier.scopusauthoridDvornyk, V=6701789786en_HK

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