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Article: Intraoperative remifentanil infusion does not increase postoperative opioid consumption compared with 70% nitrous oxide

TitleIntraoperative remifentanil infusion does not increase postoperative opioid consumption compared with 70% nitrous oxide
Authors
Issue Date2005
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anesthesiology.org
Citation
Anesthesiology, 2005, v. 102 n. 2, p. 398-402 How to Cite?
AbstractBackground: Remifentanil is commonly used to replace nitrous oxide in general anesthesia to avoid the side effects of the latter. However, there are reports that intraoperative remifentanil infusion can lead to acute opioid tolerance. In this study, the authors tried to determine the dose of remifentanil comparable in efficacy to 70% nitrous oxide and to evaluate its effect on postoperative pain and morphine consumption after colorectal surgery using isoflurane anesthesia. Methods: Sixty adult patients undergoing open colorectal surgery were randomly assigned to receive either remifentanil or 70% nitrous oxide along with isoflurane anesthesia. After morphine analgesia titration in the postanesthesia care unit, patient-controlled analgesia was commenced. Morphine consumption and pain were scored at rest and during cough or movement for 24 h. Results: The mean remifentanil infusion rate was 0.17 μg· kg -1·min -1. The median visual analog pain score on arrival in the postanesthesla care unit was 1 (0-10) in the nitrous oxide group and 3 (0-9) in the remifentanil group (P < 0.05). Otherwise, there was no difference in pain scores at 5, 10, and 15 min and no difference in the total morphine consumption during the stay in the postanesthesia care unit. The two groups had similar total morphine consumption in the first 24 h and pain scores at rest and during movement. The incidence of postoperative nausea and vomiting was 10% in both groups. There was no difference in the sedation scores. Conclusion: The substitution of 70% nitrous oxide with remifentanil at a mean infusion rate of 0.17 μg·kg -1·minute -1 for colorectal surgery did not affect postoperative opioid consumption.
Persistent Identifierhttp://hdl.handle.net/10722/145539
ISSN
2015 Impact Factor: 5.264
2015 SCImago Journal Rankings: 2.162
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, LHYen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorLui, SKen_HK
dc.date.accessioned2012-02-28T01:53:17Z-
dc.date.available2012-02-28T01:53:17Z-
dc.date.issued2005en_HK
dc.identifier.citationAnesthesiology, 2005, v. 102 n. 2, p. 398-402en_HK
dc.identifier.issn0003-3022en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145539-
dc.description.abstractBackground: Remifentanil is commonly used to replace nitrous oxide in general anesthesia to avoid the side effects of the latter. However, there are reports that intraoperative remifentanil infusion can lead to acute opioid tolerance. In this study, the authors tried to determine the dose of remifentanil comparable in efficacy to 70% nitrous oxide and to evaluate its effect on postoperative pain and morphine consumption after colorectal surgery using isoflurane anesthesia. Methods: Sixty adult patients undergoing open colorectal surgery were randomly assigned to receive either remifentanil or 70% nitrous oxide along with isoflurane anesthesia. After morphine analgesia titration in the postanesthesia care unit, patient-controlled analgesia was commenced. Morphine consumption and pain were scored at rest and during cough or movement for 24 h. Results: The mean remifentanil infusion rate was 0.17 μg· kg -1·min -1. The median visual analog pain score on arrival in the postanesthesla care unit was 1 (0-10) in the nitrous oxide group and 3 (0-9) in the remifentanil group (P < 0.05). Otherwise, there was no difference in pain scores at 5, 10, and 15 min and no difference in the total morphine consumption during the stay in the postanesthesia care unit. The two groups had similar total morphine consumption in the first 24 h and pain scores at rest and during movement. The incidence of postoperative nausea and vomiting was 10% in both groups. There was no difference in the sedation scores. Conclusion: The substitution of 70% nitrous oxide with remifentanil at a mean infusion rate of 0.17 μg·kg -1·minute -1 for colorectal surgery did not affect postoperative opioid consumption.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anesthesiology.orgen_HK
dc.relation.ispartofAnesthesiologyen_HK
dc.subject.meshAnalgesics, Opioid - administration and dosage-
dc.subject.meshColorectal Surgery - methods-
dc.subject.meshIntraoperative Care - methods-
dc.subject.meshNitrous Oxide - administration and dosage-
dc.subject.meshPain, Postoperative - drug therapy-
dc.titleIntraoperative remifentanil infusion does not increase postoperative opioid consumption compared with 70% nitrous oxideen_HK
dc.typeArticleen_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1097/00000542-200502000-00024en_HK
dc.identifier.pmid15681957-
dc.identifier.scopuseid_2-s2.0-13244273803en_HK
dc.identifier.hkuros97414en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13244273803&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume102en_HK
dc.identifier.issue2en_HK
dc.identifier.spage398en_HK
dc.identifier.epage402en_HK
dc.identifier.isiWOS:000226755300022-
dc.publisher.placeUnited Statesen_HK

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