File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The effect of celecoxib on intrathecal morphine-induced pruritus in patients undergoing Caesarean section

TitleThe effect of celecoxib on intrathecal morphine-induced pruritus in patients undergoing Caesarean section
Authors
Issue Date2004
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409
Citation
Anaesthesia (Oxford), 2004, v. 59 n. 9, p. 876-880 How to Cite?
AbstractPruritus associated with intrathecal opioid administration is particularly common in pregnancy. Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the severity of this pruritus but have undesirable side effects. The recent development of drugs that can specifically inhibit the cyclooxygenase 2 isoenzyme have become an attractive alternative. This study was designed to evaluate the efficacy of such a drug (celecoxib) in reducing intrathecal opioid-induced pruritus in a randomised double-blinded study of 60 women undergoing Caesarean section. All of them received spinal anaesthesia with 3 ml of 0.5% hyperbaric bupivacaine and 0.3 mg preservative-free morphine. After delivery of the baby, they received either oral celecoxib 200 mg or placebo. Visual analogue scores for pain and pruritus were measured at 30 min, 2, 4, 8, and 24 h. There was no difference in the severity and onset of pain and pruritus between the two groups. Timing of administration, inadequate dosing and possible altered pharmacokinetics in pregnancy may explain the lack of efficacy.
Persistent Identifierhttp://hdl.handle.net/10722/145535
ISSN
2015 Impact Factor: 3.794
2015 SCImago Journal Rankings: 1.404
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, LHYen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorLim, Jen_HK
dc.contributor.authorWong, CKen_HK
dc.date.accessioned2012-02-28T01:53:17Z-
dc.date.available2012-02-28T01:53:17Z-
dc.date.issued2004en_HK
dc.identifier.citationAnaesthesia (Oxford), 2004, v. 59 n. 9, p. 876-880en_HK
dc.identifier.issn0003-2409en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145535-
dc.description.abstractPruritus associated with intrathecal opioid administration is particularly common in pregnancy. Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the severity of this pruritus but have undesirable side effects. The recent development of drugs that can specifically inhibit the cyclooxygenase 2 isoenzyme have become an attractive alternative. This study was designed to evaluate the efficacy of such a drug (celecoxib) in reducing intrathecal opioid-induced pruritus in a randomised double-blinded study of 60 women undergoing Caesarean section. All of them received spinal anaesthesia with 3 ml of 0.5% hyperbaric bupivacaine and 0.3 mg preservative-free morphine. After delivery of the baby, they received either oral celecoxib 200 mg or placebo. Visual analogue scores for pain and pruritus were measured at 30 min, 2, 4, 8, and 24 h. There was no difference in the severity and onset of pain and pruritus between the two groups. Timing of administration, inadequate dosing and possible altered pharmacokinetics in pregnancy may explain the lack of efficacy.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409en_HK
dc.relation.ispartofAnaesthesia (Oxford)en_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.comen_US
dc.subject.meshAnalgesics, Opioid - adverse effectsen_HK
dc.subject.meshAntipruritics - therapeutic useen_HK
dc.subject.meshCesarean Sectionen_HK
dc.subject.meshPruritus - chemically induced - prevention and controlen_HK
dc.subject.meshSulfonamides - therapeutic useen_HK
dc.titleThe effect of celecoxib on intrathecal morphine-induced pruritus in patients undergoing Caesarean sectionen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, LHY: libbylee@hkucc.hku.hken_HK
dc.identifier.emailIrwin, MG: mgirwin@hkucc.hku.hk-
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2044.2004.03797.xen_HK
dc.identifier.pmid15310350en_HK
dc.identifier.scopuseid_2-s2.0-4444349344en_HK
dc.identifier.hkuros97320en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4444349344&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue9en_HK
dc.identifier.spage876en_HK
dc.identifier.epage880en_HK
dc.identifier.isiWOS:000223283800007-
dc.publisher.placeUnited Kingdomen_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats