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Article: Relationship between bispectral index, auditory evoked potential index and effect-site EC50 for propofol at two clinical end-points

TitleRelationship between bispectral index, auditory evoked potential index and effect-site EC50 for propofol at two clinical end-points
Authors
KeywordsAnaesthesia, depth
Anaesthetics i.v., propofol
Monitoring, bispectral index
Monitoring, electroencephalography
Monitoring, evoked potentials
Pharmacokinetics, propofol
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/
Citation
British Journal Of Anaesthesia, 2003, v. 90 n. 2, p. 127-131 How to Cite?
AbstractBackground. Many anaesthetists are deterred from using total i.v. anaesthesia because of uncertainty over the concentration of propofol required to prevent awareness. We predicted blood and effect-site concentrations of propofol at two clinical end-points: loss of consciousness and no response to a painful stimulus. Methods. Forty unpremedicated Caucasian patients were anaesthetized with i.v. propofol delivered by a Diprifusor target-controlled infusion (TCI). Bispectral index (BIS) and auditory evoked potential index (AEPex) were measured and blood and effect-site propofol concentrations were predicted. Logistic regression was used to estimate population values for predicted blood and effect-site propofol concentrations at the clinical end-points and to correlate these with BIS and AEPex. Results. The effect-site EC50 at loss of consciousness was 2.8 μm ml-1 with an EC05 and an EC95 of 1.5 and 4.1 μm ml-1, respectively. The predicted EC50 when there was no response to a tetanic stimulus was 5.2 μm ml-1 with an EC05 and an EC95 of 3.1 and 7.2 μm ml-1, respectively. Conclusions. Unconsciousness and lack of response to a painful stimulus occur within a defined range of effect-site concentrations, predicted by Diprifusor TCI software.
Persistent Identifierhttp://hdl.handle.net/10722/145528
ISSN
2015 Impact Factor: 5.616
2015 SCImago Journal Rankings: 2.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMilne, SEen_HK
dc.contributor.authorTroy, Aen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorKenny, GNCen_HK
dc.date.accessioned2012-02-28T01:53:15Z-
dc.date.available2012-02-28T01:53:15Z-
dc.date.issued2003en_HK
dc.identifier.citationBritish Journal Of Anaesthesia, 2003, v. 90 n. 2, p. 127-131en_HK
dc.identifier.issn0007-0912en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145528-
dc.description.abstractBackground. Many anaesthetists are deterred from using total i.v. anaesthesia because of uncertainty over the concentration of propofol required to prevent awareness. We predicted blood and effect-site concentrations of propofol at two clinical end-points: loss of consciousness and no response to a painful stimulus. Methods. Forty unpremedicated Caucasian patients were anaesthetized with i.v. propofol delivered by a Diprifusor target-controlled infusion (TCI). Bispectral index (BIS) and auditory evoked potential index (AEPex) were measured and blood and effect-site propofol concentrations were predicted. Logistic regression was used to estimate population values for predicted blood and effect-site propofol concentrations at the clinical end-points and to correlate these with BIS and AEPex. Results. The effect-site EC50 at loss of consciousness was 2.8 μm ml-1 with an EC05 and an EC95 of 1.5 and 4.1 μm ml-1, respectively. The predicted EC50 when there was no response to a tetanic stimulus was 5.2 μm ml-1 with an EC05 and an EC95 of 3.1 and 7.2 μm ml-1, respectively. Conclusions. Unconsciousness and lack of response to a painful stimulus occur within a defined range of effect-site concentrations, predicted by Diprifusor TCI software.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/en_HK
dc.relation.ispartofBritish Journal of Anaesthesiaen_HK
dc.subjectAnaesthesia, depthen_HK
dc.subjectAnaesthetics i.v., propofolen_HK
dc.subjectMonitoring, bispectral indexen_HK
dc.subjectMonitoring, electroencephalographyen_HK
dc.subjectMonitoring, evoked potentialsen_HK
dc.subjectPharmacokinetics, propofolen_HK
dc.subject.meshAnesthesia, Intravenous-
dc.subject.meshAnesthetics, Intravenous - administration and dosage - blood-
dc.subject.meshElectroencephalography-
dc.subject.meshEvoked Potentials, Auditory - drug effects - physiology-
dc.subject.meshPropofol - administration and dosage - blood-
dc.titleRelationship between bispectral index, auditory evoked potential index and effect-site EC50 for propofol at two clinical end-pointsen_HK
dc.typeArticleen_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/bja/aeg035en_HK
dc.identifier.pmid12538366-
dc.identifier.scopuseid_2-s2.0-0037311796en_HK
dc.identifier.hkuros80885en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037311796&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume90en_HK
dc.identifier.issue2en_HK
dc.identifier.spage127en_HK
dc.identifier.epage131en_HK
dc.identifier.isiWOS:000180895900004-
dc.publisher.placeUnited Kingdomen_HK

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