File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans
  • Basic View
  • Metadata View
  • XML View
TitleReversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans
 
AuthorsSalvi, GE2
Aglietta, M2
Eick, S2
Sculean, A2
Lang, NP1
Ramseier, CA2
 
Issue Date2012
 
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
 
CitationClinical Oral Implants Research, 2012, v. 23 n. 2, p. 182-190 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0501.2011.02220.x
 
AbstractOBJECTIVE: To monitor clinical, microbiological and host-derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans. MATERIAL AND METHODS: Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3-week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3-week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre-determined sites around each experimental unit. CF samples were analyzed for matrix-metalloproteinase-8 (MMP-8) and interleukin-1beta (IL-1beta). Microbial samples were analyzed using DNA-DNA hybridization for 40 species. RESULTS: During 3 weeks of plaque accumulation, the median PlI and GI increased significantly at implants and teeth. Implant sites yielded a greater increase in the median GI compared with tooth sites. Over the 6-week experimental period, the CF levels of MMP-8 were statistically significantly higher at implants compared with teeth (P<0.05). The CF IL-1beta levels did not differ statistically significantly between teeth and implants (P>0.05). No differences in the total DNA counts between implant and tooth sites were found at any time points. No differences in the detection frequency were found for putative periodontal pathogens between implant and tooth sites. CONCLUSION: Peri-implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri-implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre-experimental levels of gingival and peri-implant mucosal health indicating that longer healing periods are needed.
 
ISSN0905-7161
2012 Impact Factor: 3.433
2012 SCImago Journal Rankings: 1.154
 
DOIhttp://dx.doi.org/10.1111/j.1600-0501.2011.02220.x
 
ISI Accession Number IDWOS:000299098700007
Funding AgencyGrant Number
Swiss Society of Odontology (SSO)238-09
Funding Information:

This study was supported by the Swiss Society of Odontology (SSO), Grant No. 238-09. The competent laboratory assistance of Mrs Marianne Weibel and Mrs Regula Hirschi is highly appreciated.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSalvi, GE
 
dc.contributor.authorAglietta, M
 
dc.contributor.authorEick, S
 
dc.contributor.authorSculean, A
 
dc.contributor.authorLang, NP
 
dc.contributor.authorRamseier, CA
 
dc.date.accessioned2012-02-28T01:52:58Z
 
dc.date.available2012-02-28T01:52:58Z
 
dc.date.issued2012
 
dc.description.abstractOBJECTIVE: To monitor clinical, microbiological and host-derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans. MATERIAL AND METHODS: Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3-week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3-week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre-determined sites around each experimental unit. CF samples were analyzed for matrix-metalloproteinase-8 (MMP-8) and interleukin-1beta (IL-1beta). Microbial samples were analyzed using DNA-DNA hybridization for 40 species. RESULTS: During 3 weeks of plaque accumulation, the median PlI and GI increased significantly at implants and teeth. Implant sites yielded a greater increase in the median GI compared with tooth sites. Over the 6-week experimental period, the CF levels of MMP-8 were statistically significantly higher at implants compared with teeth (P<0.05). The CF IL-1beta levels did not differ statistically significantly between teeth and implants (P>0.05). No differences in the total DNA counts between implant and tooth sites were found at any time points. No differences in the detection frequency were found for putative periodontal pathogens between implant and tooth sites. CONCLUSION: Peri-implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri-implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre-experimental levels of gingival and peri-implant mucosal health indicating that longer healing periods are needed.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationClinical Oral Implants Research, 2012, v. 23 n. 2, p. 182-190 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0501.2011.02220.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1600-0501.2011.02220.x
 
dc.identifier.epage190
 
dc.identifier.hkuros198614
 
dc.identifier.isiWOS:000299098700007
Funding AgencyGrant Number
Swiss Society of Odontology (SSO)238-09
Funding Information:

This study was supported by the Swiss Society of Odontology (SSO), Grant No. 238-09. The competent laboratory assistance of Mrs Marianne Weibel and Mrs Regula Hirschi is highly appreciated.

 
dc.identifier.issn0905-7161
2012 Impact Factor: 3.433
2012 SCImago Journal Rankings: 1.154
 
dc.identifier.issue2
 
dc.identifier.pmid21806683
 
dc.identifier.scopuseid_2-s2.0-84855933104
 
dc.identifier.spage182
 
dc.identifier.urihttp://hdl.handle.net/10722/145506
 
dc.identifier.volume23
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical Oral Implants Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.subject.meshDental Implants
 
dc.subject.meshDental Plaque - complications - microbiology
 
dc.subject.meshGingivitis - etiology - microbiology
 
dc.subject.meshJaw, Edentulous, Partially - rehabilitation
 
dc.subject.meshMucositis - etiology - microbiology
 
dc.titleReversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Salvi, GE</contributor.author>
<contributor.author>Aglietta, M</contributor.author>
<contributor.author>Eick, S</contributor.author>
<contributor.author>Sculean, A</contributor.author>
<contributor.author>Lang, NP</contributor.author>
<contributor.author>Ramseier, CA</contributor.author>
<date.accessioned>2012-02-28T01:52:58Z</date.accessioned>
<date.available>2012-02-28T01:52:58Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Clinical Oral Implants Research, 2012, v. 23 n. 2, p. 182-190</identifier.citation>
<identifier.issn>0905-7161</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/145506</identifier.uri>
<description.abstract>OBJECTIVE: To monitor clinical, microbiological and host-derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans. MATERIAL AND METHODS: Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3-week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3-week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre-determined sites around each experimental unit. CF samples were analyzed for matrix-metalloproteinase-8 (MMP-8) and interleukin-1beta (IL-1beta). Microbial samples were analyzed using DNA-DNA hybridization for 40 species. RESULTS: During 3 weeks of plaque accumulation, the median PlI and GI increased significantly at implants and teeth. Implant sites yielded a greater increase in the median GI compared with tooth sites. Over the 6-week experimental period, the CF levels of MMP-8 were statistically significantly higher at implants compared with teeth (P&lt;0.05). The CF IL-1beta levels did not differ statistically significantly between teeth and implants (P&gt;0.05). No differences in the total DNA counts between implant and tooth sites were found at any time points. No differences in the detection frequency were found for putative periodontal pathogens between implant and tooth sites. CONCLUSION: Peri-implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri-implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre-experimental levels of gingival and peri-implant mucosal health indicating that longer healing periods are needed.</description.abstract>
<language>eng</language>
<publisher>Wiley-Blackwell Publishing, Inc.. The Journal&apos;s web site is located at http://www.blackwellpublishing.com/journals/CLR</publisher>
<relation.ispartof>Clinical Oral Implants Research</relation.ispartof>
<rights>The definitive version is available at www3.interscience.wiley.com</rights>
<subject.mesh>Dental Implants</subject.mesh>
<subject.mesh>Dental Plaque - complications - microbiology</subject.mesh>
<subject.mesh>Gingivitis - etiology - microbiology</subject.mesh>
<subject.mesh>Jaw, Edentulous, Partially - rehabilitation</subject.mesh>
<subject.mesh>Mucositis - etiology - microbiology</subject.mesh>
<title>Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans</title>
<type>Article</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1111/j.1600-0501.2011.02220.x</identifier.doi>
<identifier.pmid>21806683</identifier.pmid>
<identifier.scopus>eid_2-s2.0-84855933104</identifier.scopus>
<identifier.hkuros>198614</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-84855933104&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>23</identifier.volume>
<identifier.issue>2</identifier.issue>
<identifier.spage>182</identifier.spage>
<identifier.epage>190</identifier.epage>
<identifier.isi>WOS:000299098700007</identifier.isi>
<publisher.place>United States</publisher.place>
</item>
Author Affiliations
  1. Prince Philip Dental Hospital
  2. Universität Bern