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Article: Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans

TitleReversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans
Authors
Issue Date2012
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2012, v. 23 n. 2, p. 182-190 How to Cite?
AbstractOBJECTIVE: To monitor clinical, microbiological and host-derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans. MATERIAL AND METHODS: Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3-week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3-week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre-determined sites around each experimental unit. CF samples were analyzed for matrix-metalloproteinase-8 (MMP-8) and interleukin-1beta (IL-1beta). Microbial samples were analyzed using DNA-DNA hybridization for 40 species. RESULTS: During 3 weeks of plaque accumulation, the median PlI and GI increased significantly at implants and teeth. Implant sites yielded a greater increase in the median GI compared with tooth sites. Over the 6-week experimental period, the CF levels of MMP-8 were statistically significantly higher at implants compared with teeth (P<0.05). The CF IL-1beta levels did not differ statistically significantly between teeth and implants (P>0.05). No differences in the total DNA counts between implant and tooth sites were found at any time points. No differences in the detection frequency were found for putative periodontal pathogens between implant and tooth sites. CONCLUSION: Peri-implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri-implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre-experimental levels of gingival and peri-implant mucosal health indicating that longer healing periods are needed.
Persistent Identifierhttp://hdl.handle.net/10722/145506
ISSN
2014 Impact Factor: 3.889
2014 SCImago Journal Rankings: 1.290
ISI Accession Number ID
Funding AgencyGrant Number
Swiss Society of Odontology (SSO)238-09
Funding Information:

This study was supported by the Swiss Society of Odontology (SSO), Grant No. 238-09. The competent laboratory assistance of Mrs Marianne Weibel and Mrs Regula Hirschi is highly appreciated.

References

 

DC FieldValueLanguage
dc.contributor.authorSalvi, GEen_HK
dc.contributor.authorAglietta, Men_HK
dc.contributor.authorEick, Sen_HK
dc.contributor.authorSculean, Aen_HK
dc.contributor.authorLang, NPen_HK
dc.contributor.authorRamseier, CAen_HK
dc.date.accessioned2012-02-28T01:52:58Z-
dc.date.available2012-02-28T01:52:58Z-
dc.date.issued2012en_HK
dc.identifier.citationClinical Oral Implants Research, 2012, v. 23 n. 2, p. 182-190en_HK
dc.identifier.issn0905-7161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145506-
dc.description.abstractOBJECTIVE: To monitor clinical, microbiological and host-derived alterations occurring around teeth and titanium implants during the development of experimental gingivitis/mucositis and their respective healing sequence in humans. MATERIAL AND METHODS: Fifteen subjects with healthy or treated periodontal conditions and restored with dental implants underwent an experimental 3-week period of undisturbed plaque accumulation in the mandible. Subsequently, a 3-week period with optimal plaque control was instituted. At Days 0, 7, 14, 21, 28, 35 and 42, the presence/absence of plaque deposits around teeth and implants was assessed, (plaque index [PlI]) and the gingival/mucosal conditions were evaluated (gingival index[GI]). Subgingival/submucosal plaque samples and gingival/mucosal crevicular fluid (CF) samples were collected from two pre-determined sites around each experimental unit. CF samples were analyzed for matrix-metalloproteinase-8 (MMP-8) and interleukin-1beta (IL-1beta). Microbial samples were analyzed using DNA-DNA hybridization for 40 species. RESULTS: During 3 weeks of plaque accumulation, the median PlI and GI increased significantly at implants and teeth. Implant sites yielded a greater increase in the median GI compared with tooth sites. Over the 6-week experimental period, the CF levels of MMP-8 were statistically significantly higher at implants compared with teeth (P<0.05). The CF IL-1beta levels did not differ statistically significantly between teeth and implants (P>0.05). No differences in the total DNA counts between implant and tooth sites were found at any time points. No differences in the detection frequency were found for putative periodontal pathogens between implant and tooth sites. CONCLUSION: Peri-implant soft tissues developed a stronger inflammatory response to experimental plaque accumulation when compared with that of their gingival counterparts. Experimental gingivitis and peri-implant mucositis were reversible at the biomarker level. Clinically, however, 3 weeks of resumed plaque control did not yield pre-experimental levels of gingival and peri-implant mucosal health indicating that longer healing periods are needed.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_HK
dc.relation.ispartofClinical Oral Implants Researchen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subject.meshDental Implants-
dc.subject.meshDental Plaque - complications - microbiology-
dc.subject.meshGingivitis - etiology - microbiology-
dc.subject.meshJaw, Edentulous, Partially - rehabilitation-
dc.subject.meshMucositis - etiology - microbiology-
dc.titleReversibility of experimental peri-implant mucositis compared with experimental gingivitis in humansen_HK
dc.typeArticleen_HK
dc.identifier.emailSalvi, GE: giovanni.salvi@zmk.unibe.chen_HK
dc.identifier.emailLang, NP: nplang@hkucc.hku.hk-
dc.identifier.authorityLang, NP=rp00031en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0501.2011.02220.xen_HK
dc.identifier.pmid21806683-
dc.identifier.scopuseid_2-s2.0-84855933104en_HK
dc.identifier.hkuros198614en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855933104&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue2en_HK
dc.identifier.spage182en_HK
dc.identifier.epage190en_HK
dc.identifier.isiWOS:000299098700007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRamseier, CA=8921696800en_HK
dc.identifier.scopusauthoridLang, NP=7201577367en_HK
dc.identifier.scopusauthoridSculean, A=7005695622en_HK
dc.identifier.scopusauthoridEick, S=7006390302en_HK
dc.identifier.scopusauthoridAglietta, M=22978529500en_HK
dc.identifier.scopusauthoridSalvi, GE=35600695300en_HK

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