File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Patient maintained alfentanil target-controlled infusion for analgesia during extracorporeal shock wave lithotripsy

TitlePatient maintained alfentanil target-controlled infusion for analgesia during extracorporeal shock wave lithotripsy
Authors
Issue Date1996
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/medicine/anesthesiology/journal/12630
Citation
Canadian Journal of Anaesthesia, 1996, v. 43 n. 9, p. 919-924 How to Cite?
AbstractPURPOSE: The purpose of this study was to determine whether alfentanil given by a pharmacokinetic-based target controlled infusion (TCI) system under patient control is a suitable analgesic technique for extracorporeal shock wave lithotripsy (ESWL). METHODS: The design was an open, unblinded, noncomparative, prospective study. Forty outpatients undergoing ESWL were given patient maintained alfentanil TCI. Pain, nausea and sedation were assessed every 300 shocks. Vital signs were recorded every three minutes, pulse oximetry and electrocardiography being monitored continuously. Blood alfentanil concentration was measured for comparison with the predicted value. RESULTS: Alfentanil consumption (median 1.34 mg, range 0.8-3.6) and measured levels following treatment (median 60 ng.ml-1, range 15.6-134.3) varied widely. The precision of the TCI system and the median prediction error (bias) were both 49%. The median of pain scores recorded during treatment was 4 (range 0-8). The median respiration rate was 15 bpm (range 10-23), three patients required oxygen (SaO2 < 92%) cardiovascular measurements were stable and there was no excessive sedation. The incidence of nausea was 15%. All patients were ready for hospital discharge within one hour following treatment. CONCLUSIONS: Patient maintained alfentanil TCI provides good analgesia for ESWL in the majority of patients with little sedation. Respiratory depression is uncommon but supplementary oxygen should be given prophylactically. There is considerable interindividual variation in demand for alfentanil indicating the usefulness of the patient control method. The TCI system underestimated alfentanil blood concentrations but this did not affect its clinical usefulness.
Persistent Identifierhttp://hdl.handle.net/10722/145502
ISSN
2015 Impact Factor: 2.139
2015 SCImago Journal Rankings: 0.884
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorCampbell, RCHen_HK
dc.contributor.authorTsui, SLen_HK
dc.contributor.authorYang, JCSen_HK
dc.date.accessioned2012-02-28T01:52:56Z-
dc.date.available2012-02-28T01:52:56Z-
dc.date.issued1996en_HK
dc.identifier.citationCanadian Journal of Anaesthesia, 1996, v. 43 n. 9, p. 919-924en_HK
dc.identifier.issn0832-610Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/145502-
dc.description.abstractPURPOSE: The purpose of this study was to determine whether alfentanil given by a pharmacokinetic-based target controlled infusion (TCI) system under patient control is a suitable analgesic technique for extracorporeal shock wave lithotripsy (ESWL). METHODS: The design was an open, unblinded, noncomparative, prospective study. Forty outpatients undergoing ESWL were given patient maintained alfentanil TCI. Pain, nausea and sedation were assessed every 300 shocks. Vital signs were recorded every three minutes, pulse oximetry and electrocardiography being monitored continuously. Blood alfentanil concentration was measured for comparison with the predicted value. RESULTS: Alfentanil consumption (median 1.34 mg, range 0.8-3.6) and measured levels following treatment (median 60 ng.ml-1, range 15.6-134.3) varied widely. The precision of the TCI system and the median prediction error (bias) were both 49%. The median of pain scores recorded during treatment was 4 (range 0-8). The median respiration rate was 15 bpm (range 10-23), three patients required oxygen (SaO2 < 92%) cardiovascular measurements were stable and there was no excessive sedation. The incidence of nausea was 15%. All patients were ready for hospital discharge within one hour following treatment. CONCLUSIONS: Patient maintained alfentanil TCI provides good analgesia for ESWL in the majority of patients with little sedation. Respiratory depression is uncommon but supplementary oxygen should be given prophylactically. There is considerable interindividual variation in demand for alfentanil indicating the usefulness of the patient control method. The TCI system underestimated alfentanil blood concentrations but this did not affect its clinical usefulness.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/medicine/anesthesiology/journal/12630en_HK
dc.relation.ispartofCanadian Journal of Anaesthesiaen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshAlfentanil - administration and dosageen_HK
dc.subject.meshAnalgesia, Patient-Controlleden_HK
dc.subject.meshAnalgesics, Opioid - administration and dosageen_HK
dc.subject.meshLithotripsyen_HK
dc.subject.meshProspective Studiesen_HK
dc.titlePatient maintained alfentanil target-controlled infusion for analgesia during extracorporeal shock wave lithotripsyen_HK
dc.typeArticleen_HK
dc.identifier.emailIrwin, MG: mgirwin@hkucc.hku.hken_HK
dc.identifier.emailCampbell, RCH: rchcampb@hkucc.hku.hk-
dc.identifier.emailTsui, SL: sltsui@hkucc.hku.hk-
dc.identifier.emailYang, JCS: jcsyang@hkucc.hku.hk-
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/BF03011805-
dc.identifier.pmid8874909-
dc.identifier.scopuseid_2-s2.0-0029809085en_HK
dc.identifier.hkuros22743en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029809085&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue9en_HK
dc.identifier.spage919en_HK
dc.identifier.epage924en_HK
dc.identifier.isiWOS:A1996VE24000006-
dc.publisher.placeUnited Statesen_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats