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Article: Familial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relatives

TitleFamilial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relatives
Authors
KeywordsHeritability
Nicotinic acid
Prostaglandin
Recurrence risk ratio
Vulnerability indicator
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
Schizophrenia Bulletin, 2007, v. 33 n. 1, p. 174-182 How to Cite?
AbstractThough a reduced flush response to niacin has been found in schizophrenic patients, whether it is a vulnerability indicator to schizophrenia remains little known. We aimed to examine the familial aggregation in niacin flush response among schizophrenic patients and their nonpsychotic relatives. In a sample of 153 schizophrenia probands, 217 parents, 70 siblings, and 94 normal subjects, 3 concentrations (0.001 M, 0.01 M, and 0.1 M) of niacin were applied to the forearm skin and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. Both the heritability for continuous flush scores and the recurrence risk ratios for binary nonflush response in the nonpsychotic relatives of schizophrenic patients were estimated, and ordinal logistic regression analyses of relatives' niacin response on probands' were further conducted to adjust for potential confounders. The greatest heritabilities ranged from 47% (0.01 M at 10 minutes) to 54% (0.1 M at 5 minutes). The risk ratios of 0.01 M at 10 minutes (ranging from 2.60 for using score 1 or less to 5.06 for using score 0 as nonflush) and 5 minutes (1.66 for using score 0 as nonflush) were significantly greater than one. Multiple ordinal logistic regression analyses further revealed that the association between probands and relatives in niacin flush response remained after adjustment for potential confounders, including age, sex, allergy, tobacco smoking, and coffee drinking. These findings provide support for the potential of niacin flush response as a vulnerability indicator to schizophrenia. © The Author 2006. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/145498
ISSN
2015 Impact Factor: 7.757
2015 SCImago Journal Rankings: 4.051
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, SHen_HK
dc.contributor.authorLiu, CMen_HK
dc.contributor.authorChang, SSen_HK
dc.contributor.authorHwu, HGen_HK
dc.contributor.authorLiu, SKen_HK
dc.contributor.authorHwang, TJen_HK
dc.contributor.authorHsieh, MHen_HK
dc.contributor.authorGuo, SCen_HK
dc.contributor.authorChen, WJen_HK
dc.date.accessioned2012-02-23T12:11:48Z-
dc.date.available2012-02-23T12:11:48Z-
dc.date.issued2007en_HK
dc.identifier.citationSchizophrenia Bulletin, 2007, v. 33 n. 1, p. 174-182en_HK
dc.identifier.issn0586-7614en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145498-
dc.description.abstractThough a reduced flush response to niacin has been found in schizophrenic patients, whether it is a vulnerability indicator to schizophrenia remains little known. We aimed to examine the familial aggregation in niacin flush response among schizophrenic patients and their nonpsychotic relatives. In a sample of 153 schizophrenia probands, 217 parents, 70 siblings, and 94 normal subjects, 3 concentrations (0.001 M, 0.01 M, and 0.1 M) of niacin were applied to the forearm skin and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. Both the heritability for continuous flush scores and the recurrence risk ratios for binary nonflush response in the nonpsychotic relatives of schizophrenic patients were estimated, and ordinal logistic regression analyses of relatives' niacin response on probands' were further conducted to adjust for potential confounders. The greatest heritabilities ranged from 47% (0.01 M at 10 minutes) to 54% (0.1 M at 5 minutes). The risk ratios of 0.01 M at 10 minutes (ranging from 2.60 for using score 1 or less to 5.06 for using score 0 as nonflush) and 5 minutes (1.66 for using score 0 as nonflush) were significantly greater than one. Multiple ordinal logistic regression analyses further revealed that the association between probands and relatives in niacin flush response remained after adjustment for potential confounders, including age, sex, allergy, tobacco smoking, and coffee drinking. These findings provide support for the potential of niacin flush response as a vulnerability indicator to schizophrenia. © The Author 2006. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/en_HK
dc.relation.ispartofSchizophrenia Bulletinen_HK
dc.subjectHeritabilityen_HK
dc.subjectNicotinic aciden_HK
dc.subjectProstaglandinen_HK
dc.subjectRecurrence risk ratioen_HK
dc.subjectVulnerability indicatoren_HK
dc.titleFamilial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relativesen_HK
dc.typeArticleen_HK
dc.identifier.emailChang, SS: sschang@hku.hken_HK
dc.identifier.authorityChang, SS=rp01582en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/schbul/sbl038en_HK
dc.identifier.pmid16936284-
dc.identifier.pmcidPMC2632299-
dc.identifier.scopuseid_2-s2.0-33845868222en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845868222&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue1en_HK
dc.identifier.spage174en_HK
dc.identifier.epage182en_HK
dc.identifier.eissn1745-1701-
dc.identifier.isiWOS:000243070900019-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLin, SH=36046125400en_HK
dc.identifier.scopusauthoridLiu, CM=7409794479en_HK
dc.identifier.scopusauthoridChang, SS=35232386600en_HK
dc.identifier.scopusauthoridHwu, HG=7006444908en_HK
dc.identifier.scopusauthoridLiu, SK=7409462879en_HK
dc.identifier.scopusauthoridHwang, TJ=7202849080en_HK
dc.identifier.scopusauthoridHsieh, MH=13605989800en_HK
dc.identifier.scopusauthoridGuo, SC=7403648569en_HK
dc.identifier.scopusauthoridChen, WJ=37162606500en_HK
dc.identifier.citeulike7391016-

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