Article: Absent response to niacin skin patch is specific to schizophrenia and independent of smoking

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TitleAbsent response to niacin skin patch is specific to schizophrenia and independent of smoking
AuthorsLiu, CM1 4
Chang, SS2 3
Liao, SC4
Hwang, TJ4
Shieh, MH4
Liu, SK4 5
Chen, WJ3
Hwu, HG3 4
KeywordsBipolar affective disorder
Niacin skin patch
Nicotine use
Schizophrenia
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
CitationPsychiatry Research, 2007, v. 152 n. 2-3, p. 181-187 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.psychres.2006.10.002
AbstractThis study investigated the differences in niacin skin flush responses between patients with schizophrenia, bipolar mania, and normal controls. We applied niacin patches of three concentrations (0.001 M, 0.01 M, and 0.1 M) to the skin of 61 patients with schizophrenia, 18 patients with bipolar mania, and 40 normal controls for 5 min. Flush responses were rated at 5, 10 and 15 min after application. Flush responses were significantly different among three groups at the concentrations of 0.1 M and 0.01 M at all of the three rating time points. The use of nicotine did not have significant influences on the flush responses. Absent response was significantly more prevalent in the schizophrenia group than in the other two groups, but was not significantly different between the bipolar and the control group. The greatest degree of differentiation in flush responses among groups occurred at the 0.01 M concentration, and the rating time point of 10 min with 49.2% of schizophrenic patients but only 7.5% of controls and 11.1% of bipolar patients not showing a flush response. The niacin skin test for schizophrenia had 49.2% sensitivity and 92.5% specificity compared with controls. This study found that absent response to niacin skin patch was specific to schizophrenia and independent of smoking status. © 2006 Elsevier Ireland Ltd. All rights reserved.
ISSN0165-1781
2011 Impact Factor: 2.524
2011 SCImago Journal Rankings: 0.122
DOIhttp://dx.doi.org/10.1016/j.psychres.2006.10.002
ISI Accession Number IDWOS:000249333800010
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLiu, CM
dc.contributor.authorChang, SS
dc.contributor.authorLiao, SC
dc.contributor.authorHwang, TJ
dc.contributor.authorShieh, MH
dc.contributor.authorLiu, SK
dc.contributor.authorChen, WJ
dc.contributor.authorHwu, HG
dc.date.accessioned2012-02-23T12:11:47Z
dc.date.available2012-02-23T12:11:47Z
dc.date.issued2007
dc.description.abstractThis study investigated the differences in niacin skin flush responses between patients with schizophrenia, bipolar mania, and normal controls. We applied niacin patches of three concentrations (0.001 M, 0.01 M, and 0.1 M) to the skin of 61 patients with schizophrenia, 18 patients with bipolar mania, and 40 normal controls for 5 min. Flush responses were rated at 5, 10 and 15 min after application. Flush responses were significantly different among three groups at the concentrations of 0.1 M and 0.01 M at all of the three rating time points. The use of nicotine did not have significant influences on the flush responses. Absent response was significantly more prevalent in the schizophrenia group than in the other two groups, but was not significantly different between the bipolar and the control group. The greatest degree of differentiation in flush responses among groups occurred at the 0.01 M concentration, and the rating time point of 10 min with 49.2% of schizophrenic patients but only 7.5% of controls and 11.1% of bipolar patients not showing a flush response. The niacin skin test for schizophrenia had 49.2% sensitivity and 92.5% specificity compared with controls. This study found that absent response to niacin skin patch was specific to schizophrenia and independent of smoking status. © 2006 Elsevier Ireland Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationPsychiatry Research, 2007, v. 152 n. 2-3, p. 181-187 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.psychres.2006.10.002
dc.identifier.citeulike7390904
dc.identifier.doihttp://dx.doi.org/10.1016/j.psychres.2006.10.002
dc.identifier.epage187
dc.identifier.isiWOS:000249333800010
dc.identifier.issn0165-1781
2011 Impact Factor: 2.524
2011 SCImago Journal Rankings: 0.122
dc.identifier.issue2-3
dc.identifier.pmid17459487
dc.identifier.scopuseid_2-s2.0-34547673179
dc.identifier.spage181
dc.identifier.urihttp://hdl.handle.net/10722/145497
dc.identifier.volume152
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
dc.publisher.placeIreland
dc.relation.ispartofPsychiatry Research
dc.relation.referencesReferences in Scopus
dc.subjectBipolar affective disorder
dc.subjectNiacin skin patch
dc.subjectNicotine use
dc.subjectSchizophrenia
dc.titleAbsent response to niacin skin patch is specific to schizophrenia and independent of smoking
dc.typeArticle
Author Affiliations
  1. National Taiwan University College of Medicine
  2. Ju-Shan Mental Hospital
  3. National Taiwan University
  4. National Taiwan University Hospital
  5. Far Eastern Memorial Hospital Taiwan