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Article: Absent response to niacin skin patch is specific to schizophrenia and independent of smoking
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TitleAbsent response to niacin skin patch is specific to schizophrenia and independent of smoking
 
AuthorsLiu, CM1 4
Chang, SS2 3
Liao, SC4
Hwang, TJ4
Shieh, MH4
Liu, SK5 4
Chen, WJ2
Hwu, HG4 2
 
KeywordsBipolar affective disorder
Niacin skin patch
Nicotine use
Schizophrenia
 
Issue Date2007
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
 
CitationPsychiatry Research, 2007, v. 152 n. 2-3, p. 181-187 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.psychres.2006.10.002
 
AbstractThis study investigated the differences in niacin skin flush responses between patients with schizophrenia, bipolar mania, and normal controls. We applied niacin patches of three concentrations (0.001 M, 0.01 M, and 0.1 M) to the skin of 61 patients with schizophrenia, 18 patients with bipolar mania, and 40 normal controls for 5 min. Flush responses were rated at 5, 10 and 15 min after application. Flush responses were significantly different among three groups at the concentrations of 0.1 M and 0.01 M at all of the three rating time points. The use of nicotine did not have significant influences on the flush responses. Absent response was significantly more prevalent in the schizophrenia group than in the other two groups, but was not significantly different between the bipolar and the control group. The greatest degree of differentiation in flush responses among groups occurred at the 0.01 M concentration, and the rating time point of 10 min with 49.2% of schizophrenic patients but only 7.5% of controls and 11.1% of bipolar patients not showing a flush response. The niacin skin test for schizophrenia had 49.2% sensitivity and 92.5% specificity compared with controls. This study found that absent response to niacin skin patch was specific to schizophrenia and independent of smoking status. © 2006 Elsevier Ireland Ltd. All rights reserved.
 
ISSN0165-1781
2013 Impact Factor: 2.682
2013 SCImago Journal Rankings: 1.297
 
DOIhttp://dx.doi.org/10.1016/j.psychres.2006.10.002
 
ISI Accession Number IDWOS:000249333800010
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLiu, CM
 
dc.contributor.authorChang, SS
 
dc.contributor.authorLiao, SC
 
dc.contributor.authorHwang, TJ
 
dc.contributor.authorShieh, MH
 
dc.contributor.authorLiu, SK
 
dc.contributor.authorChen, WJ
 
dc.contributor.authorHwu, HG
 
dc.date.accessioned2012-02-23T12:11:47Z
 
dc.date.available2012-02-23T12:11:47Z
 
dc.date.issued2007
 
dc.description.abstractThis study investigated the differences in niacin skin flush responses between patients with schizophrenia, bipolar mania, and normal controls. We applied niacin patches of three concentrations (0.001 M, 0.01 M, and 0.1 M) to the skin of 61 patients with schizophrenia, 18 patients with bipolar mania, and 40 normal controls for 5 min. Flush responses were rated at 5, 10 and 15 min after application. Flush responses were significantly different among three groups at the concentrations of 0.1 M and 0.01 M at all of the three rating time points. The use of nicotine did not have significant influences on the flush responses. Absent response was significantly more prevalent in the schizophrenia group than in the other two groups, but was not significantly different between the bipolar and the control group. The greatest degree of differentiation in flush responses among groups occurred at the 0.01 M concentration, and the rating time point of 10 min with 49.2% of schizophrenic patients but only 7.5% of controls and 11.1% of bipolar patients not showing a flush response. The niacin skin test for schizophrenia had 49.2% sensitivity and 92.5% specificity compared with controls. This study found that absent response to niacin skin patch was specific to schizophrenia and independent of smoking status. © 2006 Elsevier Ireland Ltd. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationPsychiatry Research, 2007, v. 152 n. 2-3, p. 181-187 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.psychres.2006.10.002
 
dc.identifier.citeulike7390904
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.psychres.2006.10.002
 
dc.identifier.epage187
 
dc.identifier.isiWOS:000249333800010
 
dc.identifier.issn0165-1781
2013 Impact Factor: 2.682
2013 SCImago Journal Rankings: 1.297
 
dc.identifier.issue2-3
 
dc.identifier.pmid17459487
 
dc.identifier.scopuseid_2-s2.0-34547673179
 
dc.identifier.spage181
 
dc.identifier.urihttp://hdl.handle.net/10722/145497
 
dc.identifier.volume152
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
 
dc.publisher.placeIreland
 
dc.relation.ispartofPsychiatry Research
 
dc.relation.referencesReferences in Scopus
 
dc.subjectBipolar affective disorder
 
dc.subjectNiacin skin patch
 
dc.subjectNicotine use
 
dc.subjectSchizophrenia
 
dc.titleAbsent response to niacin skin patch is specific to schizophrenia and independent of smoking
 
dc.typeArticle
 
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<contributor.author>Liao, SC</contributor.author>
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<contributor.author>Shieh, MH</contributor.author>
<contributor.author>Liu, SK</contributor.author>
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Author Affiliations
  1. National Taiwan University College of Medicine
  2. National Taiwan University
  3. Ju-Shan Mental Hospital
  4. National Taiwan University Hospital
  5. Far Eastern Memorial Hospital Taiwan