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Article: Absent response to niacin skin patch is specific to schizophrenia and independent of smoking

TitleAbsent response to niacin skin patch is specific to schizophrenia and independent of smoking
Authors
KeywordsBipolar affective disorder
Niacin skin patch
Nicotine use
Schizophrenia
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
Citation
Psychiatry Research, 2007, v. 152 n. 2-3, p. 181-187 How to Cite?
AbstractThis study investigated the differences in niacin skin flush responses between patients with schizophrenia, bipolar mania, and normal controls. We applied niacin patches of three concentrations (0.001 M, 0.01 M, and 0.1 M) to the skin of 61 patients with schizophrenia, 18 patients with bipolar mania, and 40 normal controls for 5 min. Flush responses were rated at 5, 10 and 15 min after application. Flush responses were significantly different among three groups at the concentrations of 0.1 M and 0.01 M at all of the three rating time points. The use of nicotine did not have significant influences on the flush responses. Absent response was significantly more prevalent in the schizophrenia group than in the other two groups, but was not significantly different between the bipolar and the control group. The greatest degree of differentiation in flush responses among groups occurred at the 0.01 M concentration, and the rating time point of 10 min with 49.2% of schizophrenic patients but only 7.5% of controls and 11.1% of bipolar patients not showing a flush response. The niacin skin test for schizophrenia had 49.2% sensitivity and 92.5% specificity compared with controls. This study found that absent response to niacin skin patch was specific to schizophrenia and independent of smoking status. © 2006 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/145497
ISSN
2014 Impact Factor: 2.467
2014 SCImago Journal Rankings: 1.106
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, CMen_HK
dc.contributor.authorChang, SSen_HK
dc.contributor.authorLiao, SCen_HK
dc.contributor.authorHwang, TJen_HK
dc.contributor.authorShieh, MHen_HK
dc.contributor.authorLiu, SKen_HK
dc.contributor.authorChen, WJen_HK
dc.contributor.authorHwu, HGen_HK
dc.date.accessioned2012-02-23T12:11:47Z-
dc.date.available2012-02-23T12:11:47Z-
dc.date.issued2007en_HK
dc.identifier.citationPsychiatry Research, 2007, v. 152 n. 2-3, p. 181-187en_HK
dc.identifier.issn0165-1781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145497-
dc.description.abstractThis study investigated the differences in niacin skin flush responses between patients with schizophrenia, bipolar mania, and normal controls. We applied niacin patches of three concentrations (0.001 M, 0.01 M, and 0.1 M) to the skin of 61 patients with schizophrenia, 18 patients with bipolar mania, and 40 normal controls for 5 min. Flush responses were rated at 5, 10 and 15 min after application. Flush responses were significantly different among three groups at the concentrations of 0.1 M and 0.01 M at all of the three rating time points. The use of nicotine did not have significant influences on the flush responses. Absent response was significantly more prevalent in the schizophrenia group than in the other two groups, but was not significantly different between the bipolar and the control group. The greatest degree of differentiation in flush responses among groups occurred at the 0.01 M concentration, and the rating time point of 10 min with 49.2% of schizophrenic patients but only 7.5% of controls and 11.1% of bipolar patients not showing a flush response. The niacin skin test for schizophrenia had 49.2% sensitivity and 92.5% specificity compared with controls. This study found that absent response to niacin skin patch was specific to schizophrenia and independent of smoking status. © 2006 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresen_HK
dc.relation.ispartofPsychiatry Researchen_HK
dc.subjectBipolar affective disorderen_HK
dc.subjectNiacin skin patchen_HK
dc.subjectNicotine useen_HK
dc.subjectSchizophreniaen_HK
dc.titleAbsent response to niacin skin patch is specific to schizophrenia and independent of smokingen_HK
dc.typeArticleen_HK
dc.identifier.emailChang, SS: sschang@hku.hken_HK
dc.identifier.authorityChang, SS=rp01582en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.psychres.2006.10.002en_HK
dc.identifier.pmid17459487en_HK
dc.identifier.scopuseid_2-s2.0-34547673179en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547673179&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume152en_HK
dc.identifier.issue2-3en_HK
dc.identifier.spage181en_HK
dc.identifier.epage187en_HK
dc.identifier.isiWOS:000249333800010-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLiu, CM=7409794479en_HK
dc.identifier.scopusauthoridChang, SS=35232386600en_HK
dc.identifier.scopusauthoridLiao, SC=7401923076en_HK
dc.identifier.scopusauthoridHwang, TJ=7202849080en_HK
dc.identifier.scopusauthoridShieh, MH=13202970700en_HK
dc.identifier.scopusauthoridLiu, SK=7409462879en_HK
dc.identifier.scopusauthoridChen, WJ=7409647200en_HK
dc.identifier.scopusauthoridHwu, HG=35279834600en_HK
dc.identifier.citeulike7390904-

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