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Article: Impaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: The effect of genetic loading

TitleImpaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: The effect of genetic loading
Authors
KeywordsNiacin skin test
Nicotinic acid
Prostaglandin
Vulnerability indicator
Issue Date2009
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
Schizophrenia Bulletin, 2009, v. 35 n. 1, p. 213-221 How to Cite?
AbstractWe previously reported familial aggregation in flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives. However, little is known about whether this abnormal skin response is associated with genetic loading for schizophrenia. This study compared the niacin flush response in subjects from families with only one member affected with schizophrenia (simplex families) with those from families having a sib-pair with schizophrenia (multiplex families). Subjects were patients with schizophrenia and their nonpsychotic first-degree relatives from simplex families (176 probands, 260 parents, and 80 siblings) and multiplex families (311 probands, 180 parents, and 52 siblings) as well as 94 healthy controls. Niacin patches of 3 concentrations (0.001M, 0.01M, and 0.1M) were applied to forearm skin, and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. More attenuated flush response to topical niacin was shown in schizophrenia probands and their relatives from multiplex families than in their counterparts from simplex families, and the differentiation was better revealed using 0.1M concentration of niacin than 0.01M or 0.001M. For the highest concentration of 0.1M and the longest time lag of 15 minutes, a subgroup of probands (23%), parents (27%), and siblings (19%) still exhibited nonflush response. Flush response to niacin skin patch is more impaired in schizophrenia patients and their relatives from families with higher genetic loading for schizophrenia, and this finding has implications for future genetic dissection of schizophrenia. © 2008 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/145496
ISSN
2015 Impact Factor: 7.757
2015 SCImago Journal Rankings: 4.051
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
US National Institute of Mental Health1R01-MH-59624-01
National Health Research Institutes, TaiwanNHRI-90-8825PP
NHRI-EX91
92-9113PP
NHRI-CNMG-9006S
NHRI-EX93-9113PP
National Science Council, TaiwanNSC-91-3112-B-002-011
NSC-92-3112-B-002-019
NSC-93-3112-B-002-012
National Taiwan University HospitalNTUH-90S1562
Funding Information:

US National Institute of Mental Health (1R01-MH-59624-01); National Health Research Institutes, Taiwan (NHRI-90-8825PP, NHRI-EX91, 92-9113PP, NHRI-CNMG-9006S, NHRI-EX93-9113PP); National Science Council, Taiwan (NSC-91-3112-B-002-011, NSC-92-3112-B-002-019, NSC-93-3112-B-002-012); National Taiwan University Hospital (NTUH-90S1562).

References

 

DC FieldValueLanguage
dc.contributor.authorChang, SSen_HK
dc.contributor.authorLiu, CMen_HK
dc.contributor.authorLin, SHen_HK
dc.contributor.authorHwu, HGen_HK
dc.contributor.authorHwang, TJen_HK
dc.contributor.authorLiu, SKen_HK
dc.contributor.authorHsieh, MHen_HK
dc.contributor.authorGuo, SCen_HK
dc.contributor.authorChen, WJen_HK
dc.date.accessioned2012-02-23T12:11:47Z-
dc.date.available2012-02-23T12:11:47Z-
dc.date.issued2009en_HK
dc.identifier.citationSchizophrenia Bulletin, 2009, v. 35 n. 1, p. 213-221en_HK
dc.identifier.issn0586-7614en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145496-
dc.description.abstractWe previously reported familial aggregation in flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives. However, little is known about whether this abnormal skin response is associated with genetic loading for schizophrenia. This study compared the niacin flush response in subjects from families with only one member affected with schizophrenia (simplex families) with those from families having a sib-pair with schizophrenia (multiplex families). Subjects were patients with schizophrenia and their nonpsychotic first-degree relatives from simplex families (176 probands, 260 parents, and 80 siblings) and multiplex families (311 probands, 180 parents, and 52 siblings) as well as 94 healthy controls. Niacin patches of 3 concentrations (0.001M, 0.01M, and 0.1M) were applied to forearm skin, and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. More attenuated flush response to topical niacin was shown in schizophrenia probands and their relatives from multiplex families than in their counterparts from simplex families, and the differentiation was better revealed using 0.1M concentration of niacin than 0.01M or 0.001M. For the highest concentration of 0.1M and the longest time lag of 15 minutes, a subgroup of probands (23%), parents (27%), and siblings (19%) still exhibited nonflush response. Flush response to niacin skin patch is more impaired in schizophrenia patients and their relatives from families with higher genetic loading for schizophrenia, and this finding has implications for future genetic dissection of schizophrenia. © 2008 The Authors.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/en_HK
dc.relation.ispartofSchizophrenia Bulletinen_HK
dc.subjectNiacin skin testen_HK
dc.subjectNicotinic aciden_HK
dc.subjectProstaglandinen_HK
dc.subjectVulnerability indicatoren_HK
dc.titleImpaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: The effect of genetic loadingen_HK
dc.typeArticleen_HK
dc.identifier.emailChang, SS: sschang@hku.hken_HK
dc.identifier.authorityChang, SS=rp01582en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1093/schbul/sbm153en_HK
dc.identifier.pmid18203758-
dc.identifier.pmcidPMC2643969-
dc.identifier.scopuseid_2-s2.0-57749205976en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57749205976&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue1en_HK
dc.identifier.spage213en_HK
dc.identifier.epage221en_HK
dc.identifier.eissn1745-1701-
dc.identifier.isiWOS:000261682700021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChang, SS=35232386600en_HK
dc.identifier.scopusauthoridLiu, CM=7409794479en_HK
dc.identifier.scopusauthoridLin, SH=36046125400en_HK
dc.identifier.scopusauthoridHwu, HG=7006444908en_HK
dc.identifier.scopusauthoridHwang, TJ=7202849080en_HK
dc.identifier.scopusauthoridLiu, SK=7409462879en_HK
dc.identifier.scopusauthoridHsieh, MH=13605989800en_HK
dc.identifier.scopusauthoridGuo, SC=7403648569en_HK
dc.identifier.scopusauthoridChen, WJ=7409647200en_HK
dc.identifier.citeulike7391039-

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