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Article: Outcome of patients receiving high dose vasopressor therapy: A retrospective cohort study

TitleOutcome of patients receiving high dose vasopressor therapy: A retrospective cohort study
Authors
Issue Date2009
PublisherAustralian Society of Anaesthetists. The Journal's web site is located at http://www.aaic.net.au
Citation
Anaesthesia And Intensive Care, 2009, v. 37 n. 2, p. 286-289 How to Cite?
AbstractThe aim of this study was to determine the hospital survival of patients receiving high doses of catecholamines. A retrospective observational study was conducted in a 22-bed multidisciplinary adult intensive care unit of a tertiary referral university hospital. All patients (n=64) receiving >100 μg/min of adrenaline or noradrenaline or adrenaline and noradrenaline combined over a one-year period were studied to determine survival to intensive care unit and hospital discharge. Four patients survived to intensive care unit discharge and hospital discharge (6.25%, 95% CI 0.3 to 12.2%). Survival was 3.3% (95% CI 0 to 7.9%) in the subgroup of 60 patients who received >100 μg/min noradrenaline and 3.6% (95% CI 0 to 8.6%) in the 55 patients who received >2 μg/kg/min noradrenaline. None of the 32 patients who received >200 μg/min noradrenaline survived. We conclude that the survival of patients requiring high doses of catecholamines is poor, but the use of such doses is probably not futile. It remains for individual clinicians, patients and their surrogates to decide whether use of high doses of vasopressor is appropriate, given the low probability of survival.
Persistent Identifierhttp://hdl.handle.net/10722/145446
ISSN
2015 Impact Factor: 1.283
2015 SCImago Journal Rankings: 0.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJenkins, CRen_HK
dc.contributor.authorGomersall, CDen_HK
dc.contributor.authorLeung, Pen_HK
dc.contributor.authorJoynt, GMen_HK
dc.date.accessioned2012-02-23T12:10:20Z-
dc.date.available2012-02-23T12:10:20Z-
dc.date.issued2009en_HK
dc.identifier.citationAnaesthesia And Intensive Care, 2009, v. 37 n. 2, p. 286-289en_HK
dc.identifier.issn0310-057Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/145446-
dc.description.abstractThe aim of this study was to determine the hospital survival of patients receiving high doses of catecholamines. A retrospective observational study was conducted in a 22-bed multidisciplinary adult intensive care unit of a tertiary referral university hospital. All patients (n=64) receiving >100 μg/min of adrenaline or noradrenaline or adrenaline and noradrenaline combined over a one-year period were studied to determine survival to intensive care unit and hospital discharge. Four patients survived to intensive care unit discharge and hospital discharge (6.25%, 95% CI 0.3 to 12.2%). Survival was 3.3% (95% CI 0 to 7.9%) in the subgroup of 60 patients who received >100 μg/min noradrenaline and 3.6% (95% CI 0 to 8.6%) in the 55 patients who received >2 μg/kg/min noradrenaline. None of the 32 patients who received >200 μg/min noradrenaline survived. We conclude that the survival of patients requiring high doses of catecholamines is poor, but the use of such doses is probably not futile. It remains for individual clinicians, patients and their surrogates to decide whether use of high doses of vasopressor is appropriate, given the low probability of survival.en_HK
dc.languageengen_US
dc.publisherAustralian Society of Anaesthetists. The Journal's web site is located at http://www.aaic.net.auen_HK
dc.relation.ispartofAnaesthesia and Intensive Careen_HK
dc.subject.meshAPACHEen_HK
dc.subject.meshAgeden_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshEpinephrine - therapeutic useen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHospital Mortalityen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntensive Care Unitsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultiple Organ Failure - mortalityen_HK
dc.subject.meshNorepinephrine - therapeutic useen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshVasoconstrictor Agents - therapeutic useen_HK
dc.titleOutcome of patients receiving high dose vasopressor therapy: A retrospective cohort studyen_HK
dc.typeArticleen_HK
dc.identifier.emailJenkins, CR:cjenkins@hkucc.hku.hken_HK
dc.identifier.authorityJenkins, CR=rp01583en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid19400494en_HK
dc.identifier.scopuseid_2-s2.0-65549137588en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65549137588&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue2en_HK
dc.identifier.spage286en_HK
dc.identifier.epage289en_HK
dc.identifier.isiWOS:000265276300016-
dc.publisher.placeAustraliaen_HK

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