File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT
  • Basic View
  • Metadata View
  • XML View
TitleQuantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT
 
AuthorsGu, J3
Khong, PL3
Wang, S3
Chan, Q1
Law, W3
Zhang, J2 3
 
KeywordsADC
DWI
PET/CT
Primary rectal adenocarcinoma
SUV
TDI
TLG
 
Issue Date2011
 
PublisherSpringer New York LLC.
 
CitationMolecular Imaging And Biology, 2011, v. 13 n. 5, p. 1020-1028 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11307-010-0433-7
 
AbstractPurpose: The aim of the study was to assess correlations between parameters on diffusionweighted imaging and 2-deoxy-2-[ 18F]fluoro-D-glucose- positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer. Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC mean (average ADC), ADC min (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV max (maximum SUV), SUV mean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold. Results: Significant negative correlations were found between ADC min and SUV max (r=-0.450, p=0.009), and between ADC mean and SUV mean (r=-0.402, p=0.020). A significant positive correlation was found between TDI and TLG (r=0.634, p<0.001). Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. © Academy of Molecular Imaging and Society for Molecular Imaging, 2010.
 
ISSN1536-1632
2013 Impact Factor: 2.869
2013 SCImago Journal Rankings: 1.068
 
DOIhttp://dx.doi.org/10.1007/s11307-010-0433-7
 
PubMed Central IDPMC3179585
 
ISI Accession Number IDWOS:000295176200023
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorGu, J
 
dc.contributor.authorKhong, PL
 
dc.contributor.authorWang, S
 
dc.contributor.authorChan, Q
 
dc.contributor.authorLaw, W
 
dc.contributor.authorZhang, J
 
dc.date.accessioned2012-02-21T05:44:46Z
 
dc.date.available2012-02-21T05:44:46Z
 
dc.date.issued2011
 
dc.description.abstractPurpose: The aim of the study was to assess correlations between parameters on diffusionweighted imaging and 2-deoxy-2-[ 18F]fluoro-D-glucose- positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer. Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC mean (average ADC), ADC min (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV max (maximum SUV), SUV mean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold. Results: Significant negative correlations were found between ADC min and SUV max (r=-0.450, p=0.009), and between ADC mean and SUV mean (r=-0.402, p=0.020). A significant positive correlation was found between TDI and TLG (r=0.634, p<0.001). Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. © Academy of Molecular Imaging and Society for Molecular Imaging, 2010.
 
dc.description.naturepublished_or_final_version
 
dc.description.otherSpringer Open Choice, 21 Feb 2012
 
dc.identifier.citationMolecular Imaging And Biology, 2011, v. 13 n. 5, p. 1020-1028 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11307-010-0433-7
 
dc.identifier.citeulike7929003
 
dc.identifier.doihttp://dx.doi.org/10.1007/s11307-010-0433-7
 
dc.identifier.eissn1860-2002
 
dc.identifier.epage1028
 
dc.identifier.hkuros192107
 
dc.identifier.isiWOS:000295176200023
 
dc.identifier.issn1536-1632
2013 Impact Factor: 2.869
2013 SCImago Journal Rankings: 1.068
 
dc.identifier.issue5
 
dc.identifier.pmcidPMC3179585
 
dc.identifier.pmid20872077
 
dc.identifier.scopuseid_2-s2.0-84855688291
 
dc.identifier.spage1020
 
dc.identifier.urihttp://hdl.handle.net/10722/145099
 
dc.identifier.volume13
 
dc.languageeng
 
dc.publisherSpringer New York LLC.
 
dc.publisher.placeUnited States
 
dc.relation.ispartofMolecular Imaging and Biology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.rightsThe Author(s)
 
dc.rightsThe original publication is available at www.springerlink.com
 
dc.subject.meshFluorodeoxyglucose F18 - diagnostic use
 
dc.subject.meshMagnetic Resonance Imaging - methods
 
dc.subject.meshHumans
 
dc.subject.meshPositron-Emission Tomography and Computed Tomography - methods
 
dc.subject.meshRectal Neoplasms - diagnosis - pathology
 
dc.subjectADC
 
dc.subjectDWI
 
dc.subjectPET/CT
 
dc.subjectPrimary rectal adenocarcinoma
 
dc.subjectSUV
 
dc.subjectTDI
 
dc.subjectTLG
 
dc.titleQuantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Gu, J</contributor.author>
<contributor.author>Khong, PL</contributor.author>
<contributor.author>Wang, S</contributor.author>
<contributor.author>Chan, Q</contributor.author>
<contributor.author>Law, W</contributor.author>
<contributor.author>Zhang, J</contributor.author>
<date.accessioned>2012-02-21T05:44:46Z</date.accessioned>
<date.available>2012-02-21T05:44:46Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>Molecular Imaging And Biology, 2011, v. 13 n. 5, p. 1020-1028</identifier.citation>
<identifier.issn>1536-1632</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/145099</identifier.uri>
<description.abstract>Purpose: The aim of the study was to assess correlations between parameters on diffusionweighted imaging and 2-deoxy-2-[ 18F]fluoro-D-glucose- positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer. Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC mean (average ADC), ADC min (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV max (maximum SUV), SUV mean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold. Results: Significant negative correlations were found between ADC min and SUV max (r=-0.450, p=0.009), and between ADC mean and SUV mean (r=-0.402, p=0.020). A significant positive correlation was found between TDI and TLG (r=0.634, p&lt;0.001). Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. &#169; Academy of Molecular Imaging and Society for Molecular Imaging, 2010.</description.abstract>
<language>eng</language>
<publisher>Springer New York LLC.</publisher>
<relation.ispartof>Molecular Imaging and Biology</relation.ispartof>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<rights>The Author(s)</rights>
<rights>The original publication is available at www.springerlink.com</rights>
<subject>ADC</subject>
<subject>DWI</subject>
<subject>PET/CT</subject>
<subject>Primary rectal adenocarcinoma</subject>
<subject>SUV</subject>
<subject>TDI</subject>
<subject>TLG</subject>
<subject.mesh>Fluorodeoxyglucose F18 - diagnostic use</subject.mesh>
<subject.mesh>Magnetic Resonance Imaging - methods</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Positron-Emission Tomography and Computed Tomography - methods</subject.mesh>
<subject.mesh>Rectal Neoplasms - diagnosis - pathology</subject.mesh>
<title>Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT</title>
<type>Article</type>
<description.nature>published_or_final_version</description.nature>
<identifier.doi>10.1007/s11307-010-0433-7</identifier.doi>
<identifier.pmid>20872077</identifier.pmid>
<identifier.pmcid>PMC3179585</identifier.pmcid>
<identifier.scopus>eid_2-s2.0-84855688291</identifier.scopus>
<identifier.hkuros>192107</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-84855688291&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>13</identifier.volume>
<identifier.issue>5</identifier.issue>
<identifier.spage>1020</identifier.spage>
<identifier.epage>1028</identifier.epage>
<identifier.eissn>1860-2002</identifier.eissn>
<identifier.isi>WOS:000295176200023</identifier.isi>
<publisher.place>United States</publisher.place>
<description.other>Springer Open Choice, 21 Feb 2012</description.other>
<identifier.citeulike>7929003</identifier.citeulike>
<bitstream.url>http://hub.hku.hk/bitstream/10722/145099/1/11307_2010_Article_433.pdf</bitstream.url>
</item>
Author Affiliations
  1. Philips Electronics Hong Kong Limited
  2. Memorial Sloan-Kettering Cancer Center
  3. The University of Hong Kong