Article: Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT

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Title	Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT
Authors	Gu, J3 Khong, PL3 Wang, S3 Chan, Q1 Law, W3 Zhang, J2 3
Keywords	ADC DWI PET/CT Primary rectal adenocarcinoma SUV TDI TLG
Issue Date	2011
Publisher	Springer New York LLC.
Citation	Molecular Imaging And Biology, 2011, v. 13 n. 5, p. 1020-1028 [How to Cite?] DOI: http://dx.doi.org/10.1007/s11307-010-0433-7
Abstract	Purpose: The aim of the study was to assess correlations between parameters on diffusionweighted imaging and 2-deoxy-2-[ 18F]fluoro-D-glucose- positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer. Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC mean (average ADC), ADC min (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV max (maximum SUV), SUV mean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold. Results: Significant negative correlations were found between ADC min and SUV max (r=-0.450, p=0.009), and between ADC mean and SUV mean (r=-0.402, p=0.020). A significant positive correlation was found between TDI and TLG (r=0.634, p<0.001). Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. © Academy of Molecular Imaging and Society for Molecular Imaging, 2010.
ISSN	1536-1632 2011 Impact Factor: 3.844 2011 SCImago Journal Rankings: 0.313
DOI	http://dx.doi.org/10.1007/s11307-010-0433-7
ISI Accession Number ID	WOS:000295176200023
PubMed Central ID	PMC3179585
References	References in Scopus

DC Field	Value
dc.contributor.author	Gu, J
dc.contributor.author	Khong, PL
dc.contributor.author	Wang, S
dc.contributor.author	Chan, Q
dc.contributor.author	Law, W
dc.contributor.author	Zhang, J
dc.date.accessioned	2012-02-21T05:44:46Z
dc.date.available	2012-02-21T05:44:46Z
dc.date.issued	2011
dc.description.abstract	Purpose: The aim of the study was to assess correlations between parameters on diffusionweighted imaging and 2-deoxy-2-[ 18F]fluoro-D-glucose- positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer. Procedures: Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADC mean (average ADC), ADC min (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUV max (maximum SUV), SUV mean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold. Results: Significant negative correlations were found between ADC min and SUV max (r=-0.450, p=0.009), and between ADC mean and SUV mean (r=-0.402, p=0.020). A significant positive correlation was found between TDI and TLG (r=0.634, p<0.001). Conclusion: The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. © Academy of Molecular Imaging and Society for Molecular Imaging, 2010.
dc.description.nature	published_or_final_version
dc.description.other	Springer Open Choice, 21 Feb 2012
dc.identifier.citation	Molecular Imaging And Biology, 2011, v. 13 n. 5, p. 1020-1028 [How to Cite?] DOI: http://dx.doi.org/10.1007/s11307-010-0433-7
dc.identifier.citeulike	7929003
dc.identifier.doi	http://dx.doi.org/10.1007/s11307-010-0433-7
dc.identifier.eissn	1860-2002
dc.identifier.epage	1028
dc.identifier.hkuros	192107
dc.identifier.isi	WOS:000295176200023
dc.identifier.issn	1536-1632 2011 Impact Factor: 3.844 2011 SCImago Journal Rankings: 0.313
dc.identifier.issue	5
dc.identifier.pmcid	PMC3179585
dc.identifier.pmid	20872077
dc.identifier.scopus	eid_2-s2.0-84855688291
dc.identifier.spage	1020
dc.identifier.uri	http://hdl.handle.net/10722/145099
dc.identifier.volume	13
dc.language	eng
dc.publisher	Springer New York LLC.
dc.publisher.place	United States
dc.relation.ispartof	Molecular Imaging and Biology
dc.relation.references	References in Scopus
dc.rights	Creative Commons: Attribution 3.0 Hong Kong License
dc.rights	The Author(s)
dc.rights	The original publication is available at www.springerlink.com
dc.subject.mesh	Fluorodeoxyglucose F18 - diagnostic use
dc.subject.mesh	Magnetic Resonance Imaging - methods
dc.subject.mesh	Humans
dc.subject.mesh	Positron-Emission Tomography and Computed Tomography - methods
dc.subject.mesh	Rectal Neoplasms - diagnosis - pathology
dc.subject	ADC
dc.subject	DWI
dc.subject	PET/CT
dc.subject	Primary rectal adenocarcinoma
dc.subject	SUV
dc.subject	TDI
dc.subject	TLG
dc.title	Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: Correlation with FDG-PET/CT
dc.type	Article

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Author Affiliations

Philips Electronics Hong Kong Limited
Memorial Sloan-Kettering Cancer Center
The University of Hong Kong