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Article: Late recurrence of hepatocellular carcinoma after liver transplantation

TitleLate recurrence of hepatocellular carcinoma after liver transplantation
Authors
KeywordsThoracic Surgery
Vascular Surgery
Medicine & Public Health
Surgery
Abdominal Surgery
Cardiac Surgery
General Surgery
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal Of Surgery, 2011, v. 35 n. 9, p. 2058-2062 How to Cite?
AbstractBackground: Long-term survival of patients with hepatocellular carcinoma (HCC) after liver transplantation is affected mainly by recurrence of HCC. There is the opinion that the chance of recurrence after 2 years post-transplantation is remote, and therefore lifelong surveillance is not justified because of limited resources. The aims of the present study were to determine the rate of late HCC recurrence (≥2 years after transplantation) and to compare the long-term patient survival outcomes between cases of early recurrence (<2 years after transplantation) and late recurrence. Patients: A total of 139 adult HCC patients having liver transplantation during the period from July 1994 to December 2007 were included in the analysis. The median follow-up period was 55 months. Thirty-two patients received deceased-donor grafts and 107 received living-donor grafts. Results: Hepatocellular carcinoma recurrence occurred in 24 (17.3%) patients, among them 22 (86%) had living-donor grafts and 7 (5%) developed late recurrence. Patients in the early recurrence group and patients in the late recurrence group had comparable demographics and disease pathology. The former group, when compared with the latter, had significantly worse overall survival at 3 years (13.3 versus 100%) and 5 years (6.67 versus 71.4%) (log-rank test; p < 0.001). Conclusions: Both early recurrence and late recurrence of HCC after liver transplantation were not uncommon, mostly detected at a subclinical stage. Regular and long-term surveillance with imaging and blood tests is essential for early detection. © 2011 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/145093
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChok, KSHen_HK
dc.contributor.authorChan, SCen_HK
dc.contributor.authorCheung, TTen_HK
dc.contributor.authorChan, ACYen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLo, CMen_HK
dc.date.accessioned2012-02-21T05:43:50Z-
dc.date.available2012-02-21T05:43:50Z-
dc.date.issued2011en_HK
dc.identifier.citationWorld Journal Of Surgery, 2011, v. 35 n. 9, p. 2058-2062en_HK
dc.identifier.issn0364-2313en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145093-
dc.description.abstractBackground: Long-term survival of patients with hepatocellular carcinoma (HCC) after liver transplantation is affected mainly by recurrence of HCC. There is the opinion that the chance of recurrence after 2 years post-transplantation is remote, and therefore lifelong surveillance is not justified because of limited resources. The aims of the present study were to determine the rate of late HCC recurrence (≥2 years after transplantation) and to compare the long-term patient survival outcomes between cases of early recurrence (<2 years after transplantation) and late recurrence. Patients: A total of 139 adult HCC patients having liver transplantation during the period from July 1994 to December 2007 were included in the analysis. The median follow-up period was 55 months. Thirty-two patients received deceased-donor grafts and 107 received living-donor grafts. Results: Hepatocellular carcinoma recurrence occurred in 24 (17.3%) patients, among them 22 (86%) had living-donor grafts and 7 (5%) developed late recurrence. Patients in the early recurrence group and patients in the late recurrence group had comparable demographics and disease pathology. The former group, when compared with the latter, had significantly worse overall survival at 3 years (13.3 versus 100%) and 5 years (6.67 versus 71.4%) (log-rank test; p < 0.001). Conclusions: Both early recurrence and late recurrence of HCC after liver transplantation were not uncommon, mostly detected at a subclinical stage. Regular and long-term surveillance with imaging and blood tests is essential for early detection. © 2011 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/en_HK
dc.relation.ispartofWorld Journal of Surgeryen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectThoracic Surgeryen_US
dc.subjectVascular Surgeryen_US
dc.subjectMedicine & Public Healthen_US
dc.subjectSurgeryen_US
dc.subjectAbdominal Surgeryen_US
dc.subjectCardiac Surgeryen_US
dc.subjectGeneral Surgeryen_US
dc.titleLate recurrence of hepatocellular carcinoma after liver transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Late Recurrence of Hepatocellular Carcinoma after Liver Transplantation&title=World Journal of Surgery&issn=03642313&date=2011-09-01&volume=35&issue=9& spage=2058&authors=Kenneth S. H. Chok, See Ching Chan, Tan To Cheung, <i>et al.</i>en_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_HK
dc.identifier.emailChan, ACY: acchan@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.authorityChan, SC=rp01568en_HK
dc.identifier.authorityChan, ACY=rp00310en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s00268-011-1146-zen_HK
dc.identifier.pmid21597889-
dc.identifier.pmcidPMC3152711-
dc.identifier.scopuseid_2-s2.0-80052267545en_HK
dc.identifier.hkuros187498-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052267545&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue9en_HK
dc.identifier.spage2058en_HK
dc.identifier.epage2062en_HK
dc.identifier.eissn1432-2323en_US
dc.identifier.isiWOS:000293705500017-
dc.publisher.placeUnited Statesen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridChok, KSH=6508229426en_HK
dc.identifier.scopusauthoridChan, SC=7404255575en_HK
dc.identifier.scopusauthoridCheung, TT=7103334165en_HK
dc.identifier.scopusauthoridChan, ACY=15828849100en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.citeulike9380459-

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