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Article: Dipole source analysis of auditory P300 response in depressive and anxiety disorders

TitleDipole source analysis of auditory P300 response in depressive and anxiety disorders
Authors
KeywordsAnxiety disorder
Auditory P300
Depressive disorder
Dipole source analysis
Issue Date2011
PublisherSpringer Netherlands
Citation
Cognitive Neurodynamics, 2011, v. 5 n. 2, p. 221-229 How to Cite?
AbstractThis paper is to study auditory event-related potential P300 in patients with anxiety and depressive disorders using dipole source analysis. Auditory P300 using 2-stimulus oddball paradigm was collected from 35 patients with anxiety disorder, 32 patients with depressive disorder, and 30 healthy controls. P300 dipole sources and peak amplitude of dipole activities were analyzed. The source analysis resulted in a 4-dipole configuration, where temporal dipoles displayed greater P300 amplitude than that of frontal dipoles. In addition, a right-greater-than-left hemispheric asymmetry of dipole magnitude was found in patients with anxiety disorder, whereas a left-greater-thanright hemispheric asymmetry of dipole magnitude was observed in depressed patients. Results indicated that the asymmetry was more prominent over the temporal dipole than that of frontal dipoles in patients. Patients with anxiety disorder may increase their efforts to enhance temporal dipole activity to compensate for a deficit in frontal cortex processing, while depressed patients show dominating reduction of right temporal activity. The opposite nature of results observed with hemispheric asymmetry in depressive and anxiety disorders could serve to be valuable information for psychiatric studies. © The Author(s) 2011. This article is published with open access at Springerlink.com.
Persistent Identifierhttp://hdl.handle.net/10722/145069
ISSN
2015 Impact Factor: 2.159
2015 SCImago Journal Rankings: 0.862
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30970779
Natural Science Foundation of Guangdong Province06028566
9151806001000009
Funding Information:

This work was supported by National Natural Science Foundation of China (Grant No: 30970779); Natural Science Foundation of Guangdong Province (Grant No. 06028566, No. 9151806001000009).

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_HK
dc.contributor.authorHu, Yen_HK
dc.contributor.authorLiu, Ten_HK
dc.contributor.authorWu, Den_HK
dc.date.accessioned2012-02-21T05:44:19Z-
dc.date.available2012-02-21T05:44:19Z-
dc.date.issued2011en_HK
dc.identifier.citationCognitive Neurodynamics, 2011, v. 5 n. 2, p. 221-229en_HK
dc.identifier.issn1871-4080en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145069-
dc.description.abstractThis paper is to study auditory event-related potential P300 in patients with anxiety and depressive disorders using dipole source analysis. Auditory P300 using 2-stimulus oddball paradigm was collected from 35 patients with anxiety disorder, 32 patients with depressive disorder, and 30 healthy controls. P300 dipole sources and peak amplitude of dipole activities were analyzed. The source analysis resulted in a 4-dipole configuration, where temporal dipoles displayed greater P300 amplitude than that of frontal dipoles. In addition, a right-greater-than-left hemispheric asymmetry of dipole magnitude was found in patients with anxiety disorder, whereas a left-greater-thanright hemispheric asymmetry of dipole magnitude was observed in depressed patients. Results indicated that the asymmetry was more prominent over the temporal dipole than that of frontal dipoles in patients. Patients with anxiety disorder may increase their efforts to enhance temporal dipole activity to compensate for a deficit in frontal cortex processing, while depressed patients show dominating reduction of right temporal activity. The opposite nature of results observed with hemispheric asymmetry in depressive and anxiety disorders could serve to be valuable information for psychiatric studies. © The Author(s) 2011. This article is published with open access at Springerlink.com.en_HK
dc.languageengen_US
dc.publisherSpringer Netherlandsen_US
dc.relation.ispartofCognitive Neurodynamicsen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectAnxiety disorderen_HK
dc.subjectAuditory P300en_HK
dc.subjectDepressive disorderen_HK
dc.subjectDipole source analysisen_HK
dc.titleDipole source analysis of auditory P300 response in depressive and anxiety disordersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Dipole source analysis of auditory P300 response in depressive and anxiety disorders&title=Cognitive Neurodynamics&issn=18714080&date=2011-06-01&volume=5&issue=2& spage=221&authors=Yuezhi Li, Yong Hu, Tiebang Liu, <i>et al.</i>en_US
dc.identifier.emailHu, Y:yhud@hku.hken_HK
dc.identifier.authorityHu, Y=rp00432en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s11571-011-9156-yen_HK
dc.identifier.pmid21826191-
dc.identifier.pmcidPMC3100469-
dc.identifier.scopuseid_2-s2.0-80051784519en_HK
dc.identifier.hkuros202310-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051784519&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue2en_HK
dc.identifier.spage221en_HK
dc.identifier.epage229en_HK
dc.identifier.eissn1871-4099en_US
dc.identifier.isiWOS:000290935300008-
dc.publisher.placeNetherlandsen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridLi, Y=14052381600en_HK
dc.identifier.scopusauthoridHu, Y=7407116091en_HK
dc.identifier.scopusauthoridLiu, T=12041688600en_HK
dc.identifier.scopusauthoridWu, D=23988162400en_HK
dc.identifier.citeulike9265121-

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