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Article: Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
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TitleKnockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
 
AuthorsYu, F3 2 1
Ng, SSM1
Chow, BKC1
Sze, J1
Lu, G3
Poon, WS3
Kung, HF3
Lin, MCM1 3
 
KeywordsAnti-invasion
Antiproliferation
Cell cycle
Glioma
IFITM1
 
Issue Date2011
 
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-594X
 
CitationJournal Of Neuro-Oncology, 2011, v. 103 n. 2, p. 187-195 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11060-010-0377-4
 
AbstractInterferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinase 9. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas. © 2010 The Author(s).
 
ISSN0167-594X
2012 Impact Factor: 3.115
2012 SCImago Journal Rankings: 1.095
 
DOIhttp://dx.doi.org/10.1007/s11060-010-0377-4
 
PubMed Central IDPMC3097340
 
ISI Accession Number IDWOS:000290773100002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYu, F
 
dc.contributor.authorNg, SSM
 
dc.contributor.authorChow, BKC
 
dc.contributor.authorSze, J
 
dc.contributor.authorLu, G
 
dc.contributor.authorPoon, WS
 
dc.contributor.authorKung, HF
 
dc.contributor.authorLin, MCM
 
dc.date.accessioned2012-02-21T05:44:17Z
 
dc.date.available2012-02-21T05:44:17Z
 
dc.date.issued2011
 
dc.description.abstractInterferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinase 9. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas. © 2010 The Author(s).
 
dc.description.naturepublished_or_final_version
 
dc.description.otherSpringer Open Choice, 21 Feb 2012
 
dc.identifier.citationJournal Of Neuro-Oncology, 2011, v. 103 n. 2, p. 187-195 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11060-010-0377-4
 
dc.identifier.citeulike7885118
 
dc.identifier.doihttp://dx.doi.org/10.1007/s11060-010-0377-4
 
dc.identifier.eissn1573-7373
 
dc.identifier.epage195
 
dc.identifier.hkuros181308
 
dc.identifier.isiWOS:000290773100002
 
dc.identifier.issn0167-594X
2012 Impact Factor: 3.115
2012 SCImago Journal Rankings: 1.095
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC3097340
 
dc.identifier.pmid20838853
 
dc.identifier.scopuseid_2-s2.0-79959840536
 
dc.identifier.spage187
 
dc.identifier.urihttp://hdl.handle.net/10722/145062
 
dc.identifier.volume103
 
dc.languageEng
 
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-594X
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Neuro-Oncology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe Author(s)
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectAnti-invasion
 
dc.subjectAntiproliferation
 
dc.subjectCell cycle
 
dc.subjectGlioma
 
dc.subjectIFITM1
 
dc.titleKnockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Zhejiang University
  3. Chinese University of Hong Kong