Article: Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells

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TitleKnockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
AuthorsYu, F1 2 3
Ng, SSM1
Chow, BKC1
Sze, J1
Lu, G3
Poon, WS3
Kung, HF3
Lin, MCM1 3
KeywordsAnti-invasion
Antiproliferation
Cell cycle
Glioma
IFITM1
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-594X
CitationJournal Of Neuro-Oncology, 2011, v. 103 n. 2, p. 187-195 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11060-010-0377-4
AbstractInterferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinase 9. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas. © 2010 The Author(s).
ISSN0167-594X
2011 Impact Factor: 3.214
2011 SCImago Journal Rankings: 0.253
DOIhttp://dx.doi.org/10.1007/s11060-010-0377-4
ISI Accession Number IDWOS:000290773100002
PubMed Central IDPMC3097340
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYu, F
dc.contributor.authorNg, SSM
dc.contributor.authorChow, BKC
dc.contributor.authorSze, J
dc.contributor.authorLu, G
dc.contributor.authorPoon, WS
dc.contributor.authorKung, HF
dc.contributor.authorLin, MCM
dc.date.accessioned2012-02-21T05:44:17Z
dc.date.available2012-02-21T05:44:17Z
dc.date.issued2011
dc.description.abstractInterferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinase 9. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas. © 2010 The Author(s).
dc.description.naturepublished_or_final_version
dc.description.otherSpringer Open Choice, 21 Feb 2012
dc.identifier.citationJournal Of Neuro-Oncology, 2011, v. 103 n. 2, p. 187-195 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11060-010-0377-4
dc.identifier.citeulike7885118
dc.identifier.doihttp://dx.doi.org/10.1007/s11060-010-0377-4
dc.identifier.eissn1573-7373
dc.identifier.epage195
dc.identifier.hkuros181308
dc.identifier.isiWOS:000290773100002
dc.identifier.issn0167-594X
2011 Impact Factor: 3.214
2011 SCImago Journal Rankings: 0.253
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmcidPMC3097340
dc.identifier.pmid20838853
dc.identifier.scopuseid_2-s2.0-79959840536
dc.identifier.spage187
dc.identifier.urihttp://hdl.handle.net/10722/145062
dc.identifier.volume103
dc.languageEng
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-594X
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Neuro-Oncology
dc.relation.referencesReferences in Scopus
dc.rightsThe Author(s)
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subjectAnti-invasion
dc.subjectAntiproliferation
dc.subjectCell cycle
dc.subjectGlioma
dc.subjectIFITM1
dc.titleKnockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Zhejiang University
  3. Chinese University of Hong Kong