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Article: Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer

TitleClinical and pathological characteristics of Chinese patients with BRCA related breast cancer
Authors
KeywordsBRCA mutation
Breast cancer
Chinese
Clinical features
Pathology
Issue Date2009
PublisherSpringer Netherlands. The Journal's web site is located at http://www.springer.com/biomed/journal/11568
Citation
Hugo Journal, 2009, v. 3 n. 1, p. 63-76 How to Cite?
AbstractBreast cancers related to BRCA mutations are associated with particular biological features. Here we report the clinical and pathological characteristics of breast cancer in Chinese women with and without BRCA mutations and of carriers of BRCA1 mutations compared to BRCA2 mutations. Two hundred and 26 high-risk Hong Kong Chinese women were tested for BRCA mutations, medical information was obtained from medical records, and risk and demographic information was obtained from personal interviews. In this cohort, 28 (12.4%) women were BRCA mutation carriers and among these carriers, 39.3% were BRCA1 and 60.7% were BRCA2 mutations. Mutation carriers were more likely to have a familial history of breast and ovarian cancer, high-grade cancers, and triple negative (TN) cancers. Prevalence of TN was 48.3% in BRCA carriers and 25.6% in non-carriers and was 67.7% in BRCA1 and 35.3% in BRCA2 carriers. Estrogen receptor (ER) negative cancer was significantly associated with BRCA1 mutations, especially in those under 40 years of age. BRCA-related breast cancer in this Chinese population is associated with family history and adverse pathological/prognostic features, with BRCA2 mutations being more prevalent but BRCA1 carriers having more aggressive and TN cancers. Compared to Caucasian populations, prevalence of BRCA2 mutations and TN cancer in BRCA2 mutation carriers in Chinese population are elevated. © The Author(s) 2010.
Persistent Identifierhttp://hdl.handle.net/10722/144981
ISSN
2015 SCImago Journal Rankings: 2.132
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, Aen_HK
dc.contributor.authorWong, LPen_HK
dc.contributor.authorWong, HNen_HK
dc.contributor.authorLaw, FBFen_HK
dc.contributor.authorNg, EKOen_HK
dc.contributor.authorTang, YHen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorSuen, DTKen_HK
dc.contributor.authorChoi, Cen_HK
dc.contributor.authorHo, LSen_HK
dc.contributor.authorKwan, KHen_HK
dc.contributor.authorPoon, Men_HK
dc.contributor.authorWong, TTen_HK
dc.contributor.authorChan, Ken_HK
dc.contributor.authorChan, SWWen_HK
dc.contributor.authorYing, MWLen_HK
dc.contributor.authorChan, WCen_HK
dc.contributor.authorMa, ESKen_HK
dc.contributor.authorFord, JMen_HK
dc.contributor.authorWest, DWen_HK
dc.date.accessioned2012-02-21T05:43:24Z-
dc.date.available2012-02-21T05:43:24Z-
dc.date.issued2009en_HK
dc.identifier.citationHugo Journal, 2009, v. 3 n. 1, p. 63-76en_HK
dc.identifier.issn1877-6558en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144981-
dc.description.abstractBreast cancers related to BRCA mutations are associated with particular biological features. Here we report the clinical and pathological characteristics of breast cancer in Chinese women with and without BRCA mutations and of carriers of BRCA1 mutations compared to BRCA2 mutations. Two hundred and 26 high-risk Hong Kong Chinese women were tested for BRCA mutations, medical information was obtained from medical records, and risk and demographic information was obtained from personal interviews. In this cohort, 28 (12.4%) women were BRCA mutation carriers and among these carriers, 39.3% were BRCA1 and 60.7% were BRCA2 mutations. Mutation carriers were more likely to have a familial history of breast and ovarian cancer, high-grade cancers, and triple negative (TN) cancers. Prevalence of TN was 48.3% in BRCA carriers and 25.6% in non-carriers and was 67.7% in BRCA1 and 35.3% in BRCA2 carriers. Estrogen receptor (ER) negative cancer was significantly associated with BRCA1 mutations, especially in those under 40 years of age. BRCA-related breast cancer in this Chinese population is associated with family history and adverse pathological/prognostic features, with BRCA2 mutations being more prevalent but BRCA1 carriers having more aggressive and TN cancers. Compared to Caucasian populations, prevalence of BRCA2 mutations and TN cancer in BRCA2 mutation carriers in Chinese population are elevated. © The Author(s) 2010.en_HK
dc.languageengen_US
dc.publisherSpringer Netherlands. The Journal's web site is located at http://www.springer.com/biomed/journal/11568en_HK
dc.relation.ispartofHUGO Journalen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectBRCA mutationen_HK
dc.subjectBreast canceren_HK
dc.subjectChineseen_HK
dc.subjectClinical featuresen_HK
dc.subjectPathologyen_HK
dc.titleClinical and pathological characteristics of Chinese patients with BRCA related breast canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Clinical and pathological characteristics of Chinese patients with <i>BRCA</i> related breast cancer&title=The HUGO Journal&issn=18776558&date=2009-12-01&volume=3&issue=1& spage=63&authors=Ava Kwong, L. P. Wong, H. N. Wong, <i>et al.</i>en_US
dc.identifier.emailKwong, A: avakwong@hkucc.hku.hken_HK
dc.identifier.emailNg, EKO: ngko@hku.hken_HK
dc.identifier.authorityKwong, A=rp01734en_HK
dc.identifier.authorityNg, EKO=rp01364en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s11568-010-9136-zen_HK
dc.identifier.pmid20535403-
dc.identifier.pmcidPMC2881322-
dc.identifier.scopuseid_2-s2.0-77951622385en_HK
dc.identifier.hkuros171644-
dc.identifier.hkuros164475-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951622385&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue1en_HK
dc.identifier.spage63en_HK
dc.identifier.epage76en_HK
dc.identifier.eissn1877-6566en_US
dc.publisher.placeNetherlandsen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridKwong, A=8913654300en_HK
dc.identifier.scopusauthoridWong, LP=24400218000en_HK
dc.identifier.scopusauthoridWong, HN=23089414000en_HK
dc.identifier.scopusauthoridLaw, FBF=35181537900en_HK
dc.identifier.scopusauthoridNg, EKO=21135553700en_HK
dc.identifier.scopusauthoridTang, YH=35312642000en_HK
dc.identifier.scopusauthoridChan, WK=55184930200en_HK
dc.identifier.scopusauthoridSuen, DTK=8876971300en_HK
dc.identifier.scopusauthoridChoi, C=36024878500en_HK
dc.identifier.scopusauthoridHo, LS=35310437900en_HK
dc.identifier.scopusauthoridKwan, KH=7006405794en_HK
dc.identifier.scopusauthoridPoon, M=35311693900en_HK
dc.identifier.scopusauthoridWong, TT=26323418500en_HK
dc.identifier.scopusauthoridChan, K=7406034649en_HK
dc.identifier.scopusauthoridChan, SWW=26428668300en_HK
dc.identifier.scopusauthoridYing, MWL=9942143500en_HK
dc.identifier.scopusauthoridChan, WC=55523101591en_HK
dc.identifier.scopusauthoridMa, ESK=7202039934en_HK
dc.identifier.scopusauthoridFord, JM=7402915714en_HK
dc.identifier.scopusauthoridWest, DW=7401998438en_HK

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