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Article: Liver transplantation for acute-on-chronic liver failure

TitleLiver transplantation for acute-on-chronic liver failure
Authors
KeywordsAcute-on-chronic liver failure
Liver transplantation
Living donor
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0
Citation
Hepatology International, 2009, v. 3 n. 4, p. 571-581 How to Cite?
AbstractPurpose: To evaluate the outcome of liver transplantation for acute-on-chronic liver failure. Patients and methods: From November 1991 to December 2007, 517 patients underwent liver transplantation at Queen Mary Hospital, Hong Kong. Among them, 149 had acute-on-chronic liver failure as defined in the recent Asian Pacific Association for the Study of Liver Consensus Meeting. Their clinical data were reviewed and their survival outcomes were compared with those of patients who underwent liver transplantation for fulminant hepatic failure and for cirrhosis only in the same period. Results: The patients with acute-on-chronic liver failure included 50 patients having acute exacerbation of chronic hepatitis B and 99 cirrhotic patients with acute deterioration. Their median model for end-stage liver disease scores were 35 and 37, respectively. Preoperative infection (35%), hepatorenal syndrome (38%), and respiratory failure (28.8%) were common. One hundred and three patients received living donor liver grafts and 46 patients received deceased donor liver grafts. The hospital mortality rate was 4.7%. The 5-year survival rates were 93.2% for patients with acute exacerbation of chronic hepatitis B and 90.5% for cirrhotic patients with acute deterioration. The results were similar to those of the patients with fulminant hepatic failure (n = 37) and the patients having cirrhosis only (n = 301). Conclusions: Liver transplantation for acute-on-chronic liver failure is life-saving, and the survival rates it attains are similar to those attained by transplantation for other liver conditions.
Persistent Identifierhttp://hdl.handle.net/10722/144955
ISSN
2015 Impact Factor: 1.125
2015 SCImago Journal Rankings: 0.669
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, ACen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorLiu, CLen_HK
dc.contributor.authorChan, SCen_HK
dc.contributor.authorNg, KKen_HK
dc.contributor.authorYong, BHen_HK
dc.contributor.authorChiu, Aen_HK
dc.contributor.authorLam, BKen_HK
dc.date.accessioned2012-02-21T05:44:51Z-
dc.date.available2012-02-21T05:44:51Z-
dc.date.issued2009en_HK
dc.identifier.citationHepatology International, 2009, v. 3 n. 4, p. 571-581en_HK
dc.identifier.issn1936-0533en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144955-
dc.description.abstractPurpose: To evaluate the outcome of liver transplantation for acute-on-chronic liver failure. Patients and methods: From November 1991 to December 2007, 517 patients underwent liver transplantation at Queen Mary Hospital, Hong Kong. Among them, 149 had acute-on-chronic liver failure as defined in the recent Asian Pacific Association for the Study of Liver Consensus Meeting. Their clinical data were reviewed and their survival outcomes were compared with those of patients who underwent liver transplantation for fulminant hepatic failure and for cirrhosis only in the same period. Results: The patients with acute-on-chronic liver failure included 50 patients having acute exacerbation of chronic hepatitis B and 99 cirrhotic patients with acute deterioration. Their median model for end-stage liver disease scores were 35 and 37, respectively. Preoperative infection (35%), hepatorenal syndrome (38%), and respiratory failure (28.8%) were common. One hundred and three patients received living donor liver grafts and 46 patients received deceased donor liver grafts. The hospital mortality rate was 4.7%. The 5-year survival rates were 93.2% for patients with acute exacerbation of chronic hepatitis B and 90.5% for cirrhotic patients with acute deterioration. The results were similar to those of the patients with fulminant hepatic failure (n = 37) and the patients having cirrhosis only (n = 301). Conclusions: Liver transplantation for acute-on-chronic liver failure is life-saving, and the survival rates it attains are similar to those attained by transplantation for other liver conditions.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0en_HK
dc.relation.ispartofHepatology Internationalen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectAcute-on-chronic liver failureen_HK
dc.subjectLiver transplantationen_HK
dc.subjectLiving donoren_HK
dc.subject.meshAcute-on-chronic liver failure-
dc.subject.meshLiver transplantation-
dc.subject.meshLiving donor-
dc.subject.meshAdefovir-
dc.subject.meshAspartate aminotransferase-
dc.titleLiver transplantation for acute-on-chronic liver failureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Liver transplantation for acute-on-chronic liver failure&title=Hepatology International&issn=19360533&date=2009-12-01&volume=3&issue=4& spage=571&authors=Albert C. Chan, Sheung Tat Fan, Chung Mau Lo, <i>et al.</i>en_US
dc.identifier.emailChan, AC: acchan@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_HK
dc.identifier.authorityChan, AC=rp00310en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityChan, SC=rp01568en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s12072-009-9148-8en_HK
dc.identifier.pmid19680733-
dc.identifier.pmcidPMC2790588-
dc.identifier.scopuseid_2-s2.0-73349099348en_HK
dc.identifier.hkuros166163-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-73349099348&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue4en_HK
dc.identifier.spage571en_HK
dc.identifier.epage581en_HK
dc.identifier.eissn1936-0541en_US
dc.identifier.isiWOS:000272572500008-
dc.publisher.placeUnited Statesen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridChan, AC=15828849100en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridLiu, CL=7409789712en_HK
dc.identifier.scopusauthoridChan, SC=7404255575en_HK
dc.identifier.scopusauthoridNg, KK=35248894000en_HK
dc.identifier.scopusauthoridYong, BH=7003644314en_HK
dc.identifier.scopusauthoridChiu, A=35721752900en_HK
dc.identifier.scopusauthoridLam, BK=7102023603en_HK
dc.identifier.citeulike5536939-

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