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Article: Survival Analysis of Re-resection Versus Radiofrequency Ablation for Intrahepatic Recurrence After Hepatectomy for Hepatocellular Carcinoma

TitleSurvival Analysis of Re-resection Versus Radiofrequency Ablation for Intrahepatic Recurrence After Hepatectomy for Hepatocellular Carcinoma
Authors
KeywordsVascular Surgery
Medicine & Public Health
Surgery
Abdominal Surgery
Cardiac Surgery
General Surgery
Thoracic Surgery
Issue Date2012
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal Of Surgery, 2012, v. 36 n. 1, p. 151-156 How to Cite?
AbstractBackground: Tumor recurrence after resection of hepatocellular carcinoma is a common phenomenon. Re-resection and radiofrequency ablation (RFA) are good options for treating recurrent HCC. This study compared the efficacy of these two modalities in the treatment of intrahepatic HCC recurrence after hepatectomy. Methods: From January 2001 to December 2008, a total of 179 patients developed intrahepatic HCC recurrence after hepatectomy. To treat the recurrence, 29 patients underwent re-resection and 45 patients had RFA. Patient characteristics, clinicopathologic data, and survival outcomes were reviewed. Results: Child-Pugh status, time to develop first recurrence (12.2 vs. 8.7 months), and recurrent tumor size (2.1 vs. 2.1 cm) were comparable for the two groups. Time to develop a second intrahepatic recurrence after re-resection and RFA was 5.9 and 4.0 months respectively. The 1-, 3-, and 5-year disease-free survival rates were 41.4%, 24.2%, and 24.2% after re-resection and 32.2%, 12.4%, and 9.3% after RFA (p = 0.14). The 1-, 3-, and 5-year overall survival rates were 89.7%, 56.5%, and 35.2% after re-resection and 83.7%, 43.1%, and 29.1% after RFA (p = 0.48). For the second recurrence, 33.3% of patients underwent a second round of RFA and 10.0% underwent a third resection. Conclusions: The two treatment modalities attained similar survival benefits in the management of recurrent HCC after hepatectomy. The high repeatability of RFA and that it can be delivered percutaneously render it a preferred treatment option for selected patients. © 2011 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/144948
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
PubMed Central ID
ISI Accession Number ID
References

Grazi GL, Cescon M, Ravaioli M et al (2003) Liver resection for hepatocellular carcinoma in cirrhotics and noncirrhotics: evaluation of clinicopathologic features and comparison of risk factors for long-term survival and tumour recurrence in a single centre. Aliment Pharmacol Ther 17(Suppl 2):119–129 doi: 10.1046/j.1365-2036.17.s2.9.x

Inoue K, Takayama T, Higaki T et al (2004) Clinical significance of early hepatocellular carcinoma. Liver Transpl 10(Suppl 1):S16–S19 doi: 10.1002/lt.20049

Choi JW, Park JY, Ahn SH et al (2009) Efficacy and safety of transarterial chemoembolization in recurrent hepatocellular carcinoma after curative surgical resection. Am J Clin Oncol 32:564–569 doi: 10.1097/COC.0b013e3181967da0

Shim JH, Kim KM, Lee YJ et al (2010) Complete necrosis after transarterial chemoembolization could predict prolonged survival in patients with recurrent intrahepatic hepatocellular carcinoma after curative resection. Ann Surg Oncol 17:869–877 doi: 10.1245/s10434-009-0788-7

Belghiti J, Cortes A, Abdalla EK et al (2003) Resection prior to liver transplantation for hepatocellular carcinoma. Ann Surg 238:885–892 discussion 892–893 doi: 10.1097/01.sla.0000098621.74851.65

Hwang S, Lee SG, Moon DB et al (2007) Salvage living donor liver transplantation after prior liver resection for hepatocellular carcinoma. Liver Transpl 13:741–746 doi: 10.1002/lt.21157

Minagawa M, Makuuchi M, Takayama T et al (2003) Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma. Ann Surg 238:703–710 doi: 10.1097/01.sla.0000094549.11754.e6

Fan ST (2010) Liver functional reserve estimation: state of the art and relevance for local treatments—the Eastern perspective. J Hepatobiliary Pancreat Sci 17:380–384 doi: 10.1007/s00534-009-0229-9

Fan ST, Lo CM, Liu CL et al (1999) Hepatectomy for hepatocellular carcinoma: toward zero hospital deaths. Ann Surg 229:322–330 doi: 10.1097/00000658-199903000-00004

Poon RT, Fan ST, Wong J (2000) Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg 232:10–24 doi: 10.1097/00000658-200007000-00003

Taura K, Ikai I, Hatano E et al (2006) Implication of frequent local ablation therapy for intrahepatic recurrence in prolonged survival of patients with hepatocellular carcinoma undergoing hepatic resection an analysis of 610 patients over 16 years old. Ann Surg 244:265–273 doi: 10.1097/01.sla.0000217921.28563.55

Lam VW, Ng KK, Chok KS et al (2008) Safety and efficacy of radiofrequency ablation for periductal hepatocellular carcinoma with intraductal cooling of the central bile duct. J Am Coll Surg 207:e1–e5 doi: 10.1016/j.jamcollsurg.2008.03.028

Ogawa T, Kawamoto H, Kobayashi Y et al (2010) Prevention of biliary complication in radiofrequency ablation for hepatocellular carcinoma: cooling effect by endoscopic nasobiliary drainage tube. Eur J Radiol 73:385–390 doi: 10.1016/j.ejrad.2008.10.021

Nakata Y, Haji S, Ishikawa H et al (2010) Two cases of hepatocellular carcinoma located adjacent to the Glisson’s capsule treated by laparoscopic radiofrequency ablation with intraductal chilled saline perfusion through an endoscopic nasobiliary drainage tube. Surg Laparosc Endosc Percutan Tech 20:e189–e192 doi: 10.1097/SLE.0b013e3181f91ba2

Chan AC, Chok KS, Yuen WK et al (2011) Impact of antiviral therapy on the survival of patients after major hepatectomy for hepatitis B virus-related hepatocellular carcinoma. Arch Surg 146:675–681 doi: 10.1001/archsurg.2011.125

Printz C (2009) Clinical trials of note: sorafenib as adjuvant treatment in the prevention of disease recurrence in patients with hepatocellular carcinoma (HCC) (STORM). Cancer 115:4646 doi: 10.1002/cncr.24673

Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213 doi: 10.1097/01.sla.0000133083.54934.ae

 

DC FieldValueLanguage
dc.contributor.authorChan, ACYen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorCheung, TTen_HK
dc.contributor.authorChok, KSHen_HK
dc.contributor.authorChan, SCen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLo, CMen_HK
dc.date.accessioned2012-02-21T05:43:29Z-
dc.date.available2012-02-21T05:43:29Z-
dc.date.issued2012en_HK
dc.identifier.citationWorld Journal Of Surgery, 2012, v. 36 n. 1, p. 151-156en_HK
dc.identifier.issn0364-2313en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144948-
dc.description.abstractBackground: Tumor recurrence after resection of hepatocellular carcinoma is a common phenomenon. Re-resection and radiofrequency ablation (RFA) are good options for treating recurrent HCC. This study compared the efficacy of these two modalities in the treatment of intrahepatic HCC recurrence after hepatectomy. Methods: From January 2001 to December 2008, a total of 179 patients developed intrahepatic HCC recurrence after hepatectomy. To treat the recurrence, 29 patients underwent re-resection and 45 patients had RFA. Patient characteristics, clinicopathologic data, and survival outcomes were reviewed. Results: Child-Pugh status, time to develop first recurrence (12.2 vs. 8.7 months), and recurrent tumor size (2.1 vs. 2.1 cm) were comparable for the two groups. Time to develop a second intrahepatic recurrence after re-resection and RFA was 5.9 and 4.0 months respectively. The 1-, 3-, and 5-year disease-free survival rates were 41.4%, 24.2%, and 24.2% after re-resection and 32.2%, 12.4%, and 9.3% after RFA (p = 0.14). The 1-, 3-, and 5-year overall survival rates were 89.7%, 56.5%, and 35.2% after re-resection and 83.7%, 43.1%, and 29.1% after RFA (p = 0.48). For the second recurrence, 33.3% of patients underwent a second round of RFA and 10.0% underwent a third resection. Conclusions: The two treatment modalities attained similar survival benefits in the management of recurrent HCC after hepatectomy. The high repeatability of RFA and that it can be delivered percutaneously render it a preferred treatment option for selected patients. © 2011 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/en_HK
dc.relation.ispartofWorld Journal of Surgeryen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectVascular Surgeryen_US
dc.subjectMedicine & Public Healthen_US
dc.subjectSurgeryen_US
dc.subjectAbdominal Surgeryen_US
dc.subjectCardiac Surgeryen_US
dc.subjectGeneral Surgeryen_US
dc.subjectThoracic Surgeryen_US
dc.titleSurvival Analysis of Re-resection Versus Radiofrequency Ablation for Intrahepatic Recurrence After Hepatectomy for Hepatocellular Carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Survival Analysis of Re-resection Versus Radiofrequency Ablation for Intrahepatic Recurrence After Hepatectomy for Hepatocellular Carcinoma&title=World Journal of Surgery&issn=03642313&date=2012-01-01&volume=36&issue=1& spage=151&authors=Albert C. Y. Chan, Ronnie T. P. Poon, Tan To Cheung, <i>et al.</i>en_US
dc.identifier.emailChan, ACY: acchan@hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.authorityChan, ACY=rp00310en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityChan, SC=rp01568en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s00268-011-1323-0en_HK
dc.identifier.pmid22030561-
dc.identifier.pmcidPMC3243850-
dc.identifier.scopuseid_2-s2.0-84866023032en_HK
dc.identifier.hkuros197813-
dc.relation.referencesGrazi GL, Cescon M, Ravaioli M et al (2003) Liver resection for hepatocellular carcinoma in cirrhotics and noncirrhotics: evaluation of clinicopathologic features and comparison of risk factors for long-term survival and tumour recurrence in a single centre. Aliment Pharmacol Ther 17(Suppl 2):119–129en_US
dc.relation.referencesdoi: 10.1046/j.1365-2036.17.s2.9.xen_US
dc.relation.referencesInoue K, Takayama T, Higaki T et al (2004) Clinical significance of early hepatocellular carcinoma. Liver Transpl 10(Suppl 1):S16–S19en_US
dc.relation.referencesdoi: 10.1002/lt.20049en_US
dc.relation.referencesChoi JW, Park JY, Ahn SH et al (2009) Efficacy and safety of transarterial chemoembolization in recurrent hepatocellular carcinoma after curative surgical resection. Am J Clin Oncol 32:564–569en_US
dc.relation.referencesdoi: 10.1097/COC.0b013e3181967da0en_US
dc.relation.referencesShim JH, Kim KM, Lee YJ et al (2010) Complete necrosis after transarterial chemoembolization could predict prolonged survival in patients with recurrent intrahepatic hepatocellular carcinoma after curative resection. Ann Surg Oncol 17:869–877en_US
dc.relation.referencesdoi: 10.1245/s10434-009-0788-7en_US
dc.relation.referencesBelghiti J, Cortes A, Abdalla EK et al (2003) Resection prior to liver transplantation for hepatocellular carcinoma. Ann Surg 238:885–892 discussion 892–893en_US
dc.relation.referencesdoi: 10.1097/01.sla.0000098621.74851.65en_US
dc.relation.referencesHwang S, Lee SG, Moon DB et al (2007) Salvage living donor liver transplantation after prior liver resection for hepatocellular carcinoma. Liver Transpl 13:741–746en_US
dc.relation.referencesdoi: 10.1002/lt.21157en_US
dc.relation.referencesMinagawa M, Makuuchi M, Takayama T et al (2003) Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma. Ann Surg 238:703–710en_US
dc.relation.referencesdoi: 10.1097/01.sla.0000094549.11754.e6en_US
dc.relation.referencesFan ST (2010) Liver functional reserve estimation: state of the art and relevance for local treatments—the Eastern perspective. J Hepatobiliary Pancreat Sci 17:380–384en_US
dc.relation.referencesdoi: 10.1007/s00534-009-0229-9en_US
dc.relation.referencesFan ST (2004) Protection of the liver during partial hepatectomy. Hepatobiliary Pancreat Dis Int 3:490–494en_US
dc.relation.referencesFan ST, Lo CM, Liu CL et al (1999) Hepatectomy for hepatocellular carcinoma: toward zero hospital deaths. Ann Surg 229:322–330en_US
dc.relation.referencesdoi: 10.1097/00000658-199903000-00004en_US
dc.relation.referencesErcolani G, Grazi GL, Ravaioli M et al (2003) Liver resection for hepatocellular carcinoma on cirrhosis: univariate and multivariate analysis of risk factors for intrahepatic recurrence. Ann Surg 237:536–543en_US
dc.relation.referencesPoon RT, Fan ST, Lo CM et al (2000) Long-term prognosis after resection of hepatocellular carcinoma associated with hepatitis B-related cirrhosis. J Clin Oncol 18:1094–1101en_US
dc.relation.referencesPoon RT, Fan ST, Wong J (2000) Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Ann Surg 232:10–24en_US
dc.relation.referencesdoi: 10.1097/00000658-200007000-00003en_US
dc.relation.referencesTaura K, Ikai I, Hatano E et al (2006) Implication of frequent local ablation therapy for intrahepatic recurrence in prolonged survival of patients with hepatocellular carcinoma undergoing hepatic resection an analysis of 610 patients over 16 years old. Ann Surg 244:265–273en_US
dc.relation.referencesdoi: 10.1097/01.sla.0000217921.28563.55en_US
dc.relation.referencesLam VW, Ng KK, Chok KS et al (2008) Safety and efficacy of radiofrequency ablation for periductal hepatocellular carcinoma with intraductal cooling of the central bile duct. J Am Coll Surg 207:e1–e5en_US
dc.relation.referencesdoi: 10.1016/j.jamcollsurg.2008.03.028en_US
dc.relation.referencesOgawa T, Kawamoto H, Kobayashi Y et al (2010) Prevention of biliary complication in radiofrequency ablation for hepatocellular carcinoma: cooling effect by endoscopic nasobiliary drainage tube. Eur J Radiol 73:385–390en_US
dc.relation.referencesdoi: 10.1016/j.ejrad.2008.10.021en_US
dc.relation.referencesNakata Y, Haji S, Ishikawa H et al (2010) Two cases of hepatocellular carcinoma located adjacent to the Glisson’s capsule treated by laparoscopic radiofrequency ablation with intraductal chilled saline perfusion through an endoscopic nasobiliary drainage tube. Surg Laparosc Endosc Percutan Tech 20:e189–e192en_US
dc.relation.referencesdoi: 10.1097/SLE.0b013e3181f91ba2en_US
dc.relation.referencesChan AC, Chok KS, Yuen WK et al (2011) Impact of antiviral therapy on the survival of patients after major hepatectomy for hepatitis B virus-related hepatocellular carcinoma. Arch Surg 146:675–681en_US
dc.relation.referencesdoi: 10.1001/archsurg.2011.125en_US
dc.relation.referencesPrintz C (2009) Clinical trials of note: sorafenib as adjuvant treatment in the prevention of disease recurrence in patients with hepatocellular carcinoma (HCC) (STORM). Cancer 115:4646en_US
dc.relation.referencesdoi: 10.1002/cncr.24673en_US
dc.relation.referencesDindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213en_US
dc.relation.referencesdoi: 10.1097/01.sla.0000133083.54934.aeen_US
dc.identifier.volume36en_US
dc.identifier.issue1en_US
dc.identifier.spage151en_HK
dc.identifier.epage156en_HK
dc.identifier.eissn1432-2323en_US
dc.identifier.isiWOS:000298328600022-
dc.publisher.placeUnited Statesen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridChan, ACY=15828849100en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridCheung, TT=7103334165en_HK
dc.identifier.scopusauthoridChok, KSH=6508229426en_HK
dc.identifier.scopusauthoridChan, SC=7404255575en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.citeulike9978785-

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