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Article: Early post-operative interleukin-6 and tumour necrosis factor-α levels after single-port laparoscopic varicocelectomy in children
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TitleEarly post-operative interleukin-6 and tumour necrosis factor-α levels after single-port laparoscopic varicocelectomy in children
 
AuthorsHao, W2 1
Chan, IHY2
Liu, XL
Tang, PMY2
Tam, PKH2
Wong, KKY2
 
Issue Date2012
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htm
 
CitationPediatric Surgery International, 2012, v. 28 n. 3, p. 281-286 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00383-011-3011-4
 
AbstractPURPOSE: Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this study was thus to investigate the post-operative acute inflammatory response in order to evaluate surgical stress in the two surgical approaches in children. METHODS: A prospective, single blinded, case-control study was carried out. Thirteen male patients who presented with unilateral varicocele were divided into two groups. Six children underwent single-port laparoscopic procedure, while the other seven children underwent three-port laparoscopic procedure. Pre-operative and post-operative blood samples were taken for the measurement of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) using ELISA. Demographics including the operation time, and complications were recorded. Data between the two groups were analyzed using unpaired t-test and a p value of <0.05 was taken as statistically significant. RESULTS: The mean age of patients was 14.5 years (range 12-19 years). There was no significant difference between the two groups in terms of operative time, nor there was any complication recorded. The change in serum TNF-alpha and IL-6 concentrations pre- and post-operatively between the single-port group and three-port group was not statistically significant. Overall, patients in the two groups showed excellent satisfaction in terms of post-operative cosmesis. CONCLUSION: Single-port laparoscopic varicocelectomy is safe, effective and produces excellent cosmesis with minimal surgical stress.
 
ISSN0179-0358
2012 Impact Factor: 1.216
2012 SCImago Journal Rankings: 0.567
 
DOIhttp://dx.doi.org/10.1007/s00383-011-3011-4
 
PubMed Central IDPMC3284665
 
ISI Accession Number IDWOS:000300677700011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHao, W
 
dc.contributor.authorChan, IHY
 
dc.contributor.authorLiu, XL
 
dc.contributor.authorTang, PMY
 
dc.contributor.authorTam, PKH
 
dc.contributor.authorWong, KKY
 
dc.date.accessioned2012-02-21T05:43:35Z
 
dc.date.available2012-02-21T05:43:35Z
 
dc.date.issued2012
 
dc.description.abstractPURPOSE: Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this study was thus to investigate the post-operative acute inflammatory response in order to evaluate surgical stress in the two surgical approaches in children. METHODS: A prospective, single blinded, case-control study was carried out. Thirteen male patients who presented with unilateral varicocele were divided into two groups. Six children underwent single-port laparoscopic procedure, while the other seven children underwent three-port laparoscopic procedure. Pre-operative and post-operative blood samples were taken for the measurement of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) using ELISA. Demographics including the operation time, and complications were recorded. Data between the two groups were analyzed using unpaired t-test and a p value of <0.05 was taken as statistically significant. RESULTS: The mean age of patients was 14.5 years (range 12-19 years). There was no significant difference between the two groups in terms of operative time, nor there was any complication recorded. The change in serum TNF-alpha and IL-6 concentrations pre- and post-operatively between the single-port group and three-port group was not statistically significant. Overall, patients in the two groups showed excellent satisfaction in terms of post-operative cosmesis. CONCLUSION: Single-port laparoscopic varicocelectomy is safe, effective and produces excellent cosmesis with minimal surgical stress.
 
dc.description.naturepublished_or_final_version
 
dc.description.otherSpringer Open Choice, 21 Feb 2012
 
dc.identifier.citationPediatric Surgery International, 2012, v. 28 n. 3, p. 281-286 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00383-011-3011-4
 
dc.identifier.citeulike9925242
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00383-011-3011-4
 
dc.identifier.eissn1437-9813
 
dc.identifier.epage286
 
dc.identifier.hkuros200157
 
dc.identifier.isiWOS:000300677700011
 
dc.identifier.issn0179-0358
2012 Impact Factor: 1.216
2012 SCImago Journal Rankings: 0.567
 
dc.identifier.issue3
 
dc.identifier.pmcidPMC3284665
 
dc.identifier.pmid21994078
 
dc.identifier.scopuseid_2-s2.0-84863490903
 
dc.identifier.spage281
 
dc.identifier.urihttp://hdl.handle.net/10722/144943
 
dc.identifier.volume28
 
dc.languageeng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htm
 
dc.publisher.placeGermany
 
dc.relation.ispartofPediatric Surgery International
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshInterleukin-6 - blood
 
dc.subject.meshLaparoscopy - methods
 
dc.subject.meshStress, Physiological - physiology
 
dc.subject.meshTumor Necrosis Factor-alpha - blood
 
dc.subject.meshUrologic Surgical Procedures, Male - instrumentation
 
dc.titleEarly post-operative interleukin-6 and tumour necrosis factor-α levels after single-port laparoscopic varicocelectomy in children
 
dc.typeArticle
 
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Author Affiliations
  1. Shandong University
  2. The University of Hong Kong