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Article: Early post-operative interleukin-6 and tumour necrosis factor-α levels after single-port laparoscopic varicocelectomy in children

TitleEarly post-operative interleukin-6 and tumour necrosis factor-α levels after single-port laparoscopic varicocelectomy in children
Authors
Issue Date2012
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htm
Citation
Pediatric Surgery International, 2012, v. 28 n. 3, p. 281-286 How to Cite?
AbstractPURPOSE: Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this study was thus to investigate the post-operative acute inflammatory response in order to evaluate surgical stress in the two surgical approaches in children. METHODS: A prospective, single blinded, case-control study was carried out. Thirteen male patients who presented with unilateral varicocele were divided into two groups. Six children underwent single-port laparoscopic procedure, while the other seven children underwent three-port laparoscopic procedure. Pre-operative and post-operative blood samples were taken for the measurement of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) using ELISA. Demographics including the operation time, and complications were recorded. Data between the two groups were analyzed using unpaired t-test and a p value of <0.05 was taken as statistically significant. RESULTS: The mean age of patients was 14.5 years (range 12-19 years). There was no significant difference between the two groups in terms of operative time, nor there was any complication recorded. The change in serum TNF-alpha and IL-6 concentrations pre- and post-operatively between the single-port group and three-port group was not statistically significant. Overall, patients in the two groups showed excellent satisfaction in terms of post-operative cosmesis. CONCLUSION: Single-port laparoscopic varicocelectomy is safe, effective and produces excellent cosmesis with minimal surgical stress.
Persistent Identifierhttp://hdl.handle.net/10722/144943
ISSN
2014 Impact Factor: 0.995
2014 SCImago Journal Rankings: 0.500
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHao, Wen_US
dc.contributor.authorChan, IHYen_US
dc.contributor.authorLiu, XLen_US
dc.contributor.authorTang, PMYen_US
dc.contributor.authorTam, PKHen_US
dc.contributor.authorWong, KKYen_US
dc.date.accessioned2012-02-21T05:43:35Z-
dc.date.available2012-02-21T05:43:35Z-
dc.date.issued2012en_US
dc.identifier.citationPediatric Surgery International, 2012, v. 28 n. 3, p. 281-286en_US
dc.identifier.issn0179-0358en_US
dc.identifier.urihttp://hdl.handle.net/10722/144943-
dc.description.abstractPURPOSE: Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this study was thus to investigate the post-operative acute inflammatory response in order to evaluate surgical stress in the two surgical approaches in children. METHODS: A prospective, single blinded, case-control study was carried out. Thirteen male patients who presented with unilateral varicocele were divided into two groups. Six children underwent single-port laparoscopic procedure, while the other seven children underwent three-port laparoscopic procedure. Pre-operative and post-operative blood samples were taken for the measurement of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) using ELISA. Demographics including the operation time, and complications were recorded. Data between the two groups were analyzed using unpaired t-test and a p value of <0.05 was taken as statistically significant. RESULTS: The mean age of patients was 14.5 years (range 12-19 years). There was no significant difference between the two groups in terms of operative time, nor there was any complication recorded. The change in serum TNF-alpha and IL-6 concentrations pre- and post-operatively between the single-port group and three-port group was not statistically significant. Overall, patients in the two groups showed excellent satisfaction in terms of post-operative cosmesis. CONCLUSION: Single-port laparoscopic varicocelectomy is safe, effective and produces excellent cosmesis with minimal surgical stress.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htmen_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subject.meshInterleukin-6 - blood-
dc.subject.meshLaparoscopy - methods-
dc.subject.meshStress, Physiological - physiology-
dc.subject.meshTumor Necrosis Factor-alpha - blood-
dc.subject.meshUrologic Surgical Procedures, Male - instrumentation-
dc.titleEarly post-operative interleukin-6 and tumour necrosis factor-α levels after single-port laparoscopic varicocelectomy in childrenen_US
dc.typeArticleen_US
dc.identifier.emailHao, W: haowei12875@yahoo.com.cn-
dc.identifier.emailLiu, XL: liuxl@hkucc.hku.hk-
dc.identifier.emailTam, PKH: paultam@hku.hk-
dc.identifier.emailWong, KKY: kkywong@hku.hk-
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s00383-011-3011-4en_US
dc.identifier.pmid21994078-
dc.identifier.pmcidPMC3284665-
dc.identifier.scopuseid_2-s2.0-84863490903-
dc.identifier.hkuros200157-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863490903&selection=ref&src=s&origin=recordpage-
dc.identifier.volume28-
dc.identifier.issue3-
dc.identifier.spage281en_US
dc.identifier.epage286en_US
dc.identifier.eissn1437-9813en_US
dc.identifier.isiWOS:000300677700011-
dc.publisher.placeGermany-
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.citeulike9925242-

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