File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Significance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissection

TitleSignificance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissection
Authors
KeywordsMedicine & Public Health
Surgical Oncology
Oncology
Surgery
Issue Date2012
PublisherSpringer New York
Citation
Annals of Surgical Oncology, 2012, v. 19 n. 4 p. 1257-1263 How to Cite?
AbstractBackground: Prognostic significance of metastatic central lymph node ratio (CLNR) in papillary thyroid carcinoma (PTC) remains unknown. Because postsurgical detectable stimulated thyroglobulin (DsTg) after radioiodine ablation may imply persistent or recurrent disease, we evaluated the association between CLNR and rate of DsTg in patients with PTC who underwent unilateral prophylactic central neck dissection. Methods: To be eligible for analysis, the prophylactic central neck dissection specimen had to contain ≥3 central lymph nodes (CLNs) with ≥1 harboring metastasis. Of 129 specimens, 51 (39.5%) were eligible. CLNR was calculated as follows: (number of metastatic CLNs/number of CLNs retrieved) × 100. They were categorized into group 1 (CLNR 66.67%) (n = 22). Postablation sTg level was measured 6 months after radioiodine ablation. A multivariate analysis was conducted to identify factors for postablation DsTg. Results: Young age, palpable neck swelling, large tumor size, advanced tumor, node, metastasis system (TNM) stage, and large number of metastatic CLNs were significantly associated with high CLNR (P
Persistent Identifierhttp://hdl.handle.net/10722/144942
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
PubMed Central ID
ISI Accession Number ID
References

Lang BH, Lo CY, Chan WF, Lam KY, Wan KY. Prognostic factors in papillary and follicular thyroid carcinoma: implications for cancer staging. Ann Surg Oncol. 2007;14:730–8. doi: 10.1245/s10434-006-9207-5

Machens A, Hauptmann S, Dralle H. Lymph node dissection in the lateral neck for completion in central node-positive papillary thyroid cancer. Surgery. 2009;145:176–81. doi: 10.1016/j.surg.2008.09.003

Sywak M, Cornford L, Roach P, Stalberg P, Sidhu S, Delbridge L. Routine ipsilateral level VI lymphadenectomy reduces postoperative thyroglobulin levels in papillary thyroid carcinoma. Surgery. 2006;140:1000–7. doi: 10.1016/j.surg.2006.08.001

So YK, Seo MY, Son YI. Prophylactic central lymph nodes dissection for clinically node-negative papillary thyroid microcarcinoma: influence on serum thyroglobulin level, recurrence rate, and postoperative complication. Surgery. 2011. doi:10.1016/j.surgery.2011.02.004.

Lang BH-H, Wong KP, Wan KY, Lo CY. Impact of routine unilateral central neck dissection on preablative and postablative stimulated thyroglobulin levels after total thyroidectomy in papillary thyroid carcinoma. Ann Surg Oncol. 2011. doi:10.1245/s10434-011-1833-x.

Ceelen W, Van Nieuwenhove Y, Pattyn P. Prognostic value of the lymph node ratio in stage III colorectal cancer: a systematic review. Ann Surg Oncol. 2010;17:2847–55. doi: 10.1245/s10434-010-1158-1

Celen O, Yildirim E, Berberoglu U. Prognostic impact of positive lymph node ratio in gastric carcinoma. J Surg Oncol. 2007;62:95–101. doi: 10.1002/jso.20797

Slidell MB, Chang DC, Cameron JL, et al. Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis. Ann Surg Oncol. 2008;15:165–74. doi: 10.1245/s10434-007-9587-1

Dekker JW, Peeters KC, Putter H, Vahrmeijer AL, van de Velde CJ. Metastatic lymph node ratio in stage III rectal cancer: prognostic significance in addition to the 7th edition of the TNM classification. Eur J Surg Oncol. 2010;36:1180–6. doi: 10.1016/j.ejso.2010.09.007

Takada H, Kikumori T, Imai T, Sawaki M, Shibata A, Kiuchi T. Patterns of lymph node metastases in papillary thyroid carcinoma: results from consecutive bilateral cervical lymph node dissection. World J Surg. 2011;35:1560–6. doi: 10.1007/s00268-011-1133-4

Cooper DS, Doherty GM, Hauger BR, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214. doi: 10.1089/thy.2009.0110

Lang BH, Lo CY, Chan WF, Lam KY, Wan KY. Staging systems for papillary thyroid carcinoma: a review and comparison. Ann Surg. 2007;245:366–78. doi: 10.1097/01.sla.0000250445.92336.2a

Chan WF, Lang BH, Lo CY. The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a comparative study on 1000 nerves at risk. Surgery. 2006;140:866–73. doi: 10.1016/j.surg.2006.07.017

Kim TY, Kim WB, Kim ES, et al. Serum thyroglobulin levels at the time of 131I remnant ablation just after thyroidectomy are useful for early prediction of clinical recurrence in low-risk patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2005;90:1440–5. doi: 10.1210/jc.2004-1771

Giovanella L, Ceriani L, Suriano S, Ghelfo A, Maffioli M. Thyroglobulin measurement before rh-TSH-aided 131I ablation in detecting metastases form differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2008;69:659–63. doi: 10.1111/j.1365-2265.2008.03244.x

Chung YS, Kim JY, Bae JS, et al. Lateral lymph node metastasis in papillary thyroid carcinoma: results of therapeutic lymph node dissection. Thyroid. 2009;19:241–6. doi: 10.1089/thy.2008.0244

Kloos RT, Mazzaferri EL. A single recombinant human thyrotrophin–stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later. J Clin Endocrinol Metab. 2005;90:5047–57. doi: 10.1210/jc.2005-0492

Castagna MG, Brilli L, Pilli T, Montanaro A, Cipri C, Fioravanti C, Sestini F, Capezzone M, Pacini F. Limited value of repeat recombinant thyrotropin (rhTSH)-stimulated thyroglobulin testing in differentiated thyroid carcinoma patients with previous negative rhTSHstimulated thyroglobulin and undetectable basal serum thyroglobulin levels. J Clin Endocrinol Metab. 2008;93:76–81. doi: 10.1210/jc.2007-1404

Smallridge RC, Meek SE, Morgan MA, et al. Monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human TSH-stimulated thyroglobulin in follow-up of thyroid cancer patients. J Clin Endocrinol Metab. 2007;92:82–7. doi: 10.1210/jc.2006-0993

 

DC FieldValueLanguage
dc.contributor.authorLang, BHHen_US
dc.contributor.authorWong, KPen_US
dc.contributor.authorWan, KYen_US
dc.contributor.authorLo, CYen_US
dc.date.accessioned2012-02-21T05:43:34Z-
dc.date.available2012-02-21T05:43:34Z-
dc.date.issued2012en_US
dc.identifier.citationAnnals of Surgical Oncology, 2012, v. 19 n. 4 p. 1257-1263en_US
dc.identifier.issn1068-9265en_US
dc.identifier.urihttp://hdl.handle.net/10722/144942-
dc.description.abstractBackground: Prognostic significance of metastatic central lymph node ratio (CLNR) in papillary thyroid carcinoma (PTC) remains unknown. Because postsurgical detectable stimulated thyroglobulin (DsTg) after radioiodine ablation may imply persistent or recurrent disease, we evaluated the association between CLNR and rate of DsTg in patients with PTC who underwent unilateral prophylactic central neck dissection. Methods: To be eligible for analysis, the prophylactic central neck dissection specimen had to contain ≥3 central lymph nodes (CLNs) with ≥1 harboring metastasis. Of 129 specimens, 51 (39.5%) were eligible. CLNR was calculated as follows: (number of metastatic CLNs/number of CLNs retrieved) × 100. They were categorized into group 1 (CLNR 66.67%) (n = 22). Postablation sTg level was measured 6 months after radioiodine ablation. A multivariate analysis was conducted to identify factors for postablation DsTg. Results: Young age, palpable neck swelling, large tumor size, advanced tumor, node, metastasis system (TNM) stage, and large number of metastatic CLNs were significantly associated with high CLNR (Pen_US
dc.languageengen_US
dc.publisherSpringer New Yorken_US
dc.relation.ispartofAnnals of Surgical Oncologyen_US
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectMedicine & Public Healthen_US
dc.subjectSurgical Oncologyen_US
dc.subjectOncologyen_US
dc.subjectSurgeryen_US
dc.titleSignificance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissectionen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Significance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissection&title=Annals of Surgical Oncology&issn=10689265&date=2011-10-12& spage=1&authors=Brian Hung-Hin Lang, Kai Pun Wong, Koon Yat Wan, <i>et al.</i>en_US
dc.identifier.emailLang, BHH: blang@hkucc.hku.hk-
dc.identifier.emailLo, CY: cylo@hkucc.hku.hk-
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1245/s10434-011-2105-5en_US
dc.identifier.pmid21989667-
dc.identifier.pmcidPMC3309142-
dc.identifier.scopuseid_2-s2.0-84862506505-
dc.identifier.hkuros248809-
dc.identifier.hkuros197737-
dc.relation.referencesHong Kong Cancer Registry. Cancer incidence and mortality in Hong Kong, 1983–2006. http://www3.ha.org.hk/cancereg/e_stat.asp.en_US
dc.relation.referencesLang BH, Lo CY, Chan WF, Lam KY, Wan KY. Prognostic factors in papillary and follicular thyroid carcinoma: implications for cancer staging. Ann Surg Oncol. 2007;14:730–8.en_US
dc.relation.referencesdoi: 10.1245/s10434-006-9207-5en_US
dc.relation.referencesMachens A, Hauptmann S, Dralle H. Lymph node dissection in the lateral neck for completion in central node-positive papillary thyroid cancer. Surgery. 2009;145:176–81.en_US
dc.relation.referencesdoi: 10.1016/j.surg.2008.09.003en_US
dc.relation.referencesSywak M, Cornford L, Roach P, Stalberg P, Sidhu S, Delbridge L. Routine ipsilateral level VI lymphadenectomy reduces postoperative thyroglobulin levels in papillary thyroid carcinoma. Surgery. 2006;140:1000–7.en_US
dc.relation.referencesdoi: 10.1016/j.surg.2006.08.001en_US
dc.relation.referencesSo YK, Seo MY, Son YI. Prophylactic central lymph nodes dissection for clinically node-negative papillary thyroid microcarcinoma: influence on serum thyroglobulin level, recurrence rate, and postoperative complication. Surgery. 2011. doi:10.1016/j.surgery.2011.02.004.en_US
dc.relation.referencesdoi: 10.1016/j.surgery.2011.02.004en_US
dc.relation.referencesLang BH-H, Wong KP, Wan KY, Lo CY. Impact of routine unilateral central neck dissection on preablative and postablative stimulated thyroglobulin levels after total thyroidectomy in papillary thyroid carcinoma. Ann Surg Oncol. 2011. doi:10.1245/s10434-011-1833-x.en_US
dc.relation.referencesdoi: 10.1245/s10434-011-1833-xen_US
dc.relation.referencesCeelen W, Van Nieuwenhove Y, Pattyn P. Prognostic value of the lymph node ratio in stage III colorectal cancer: a systematic review. Ann Surg Oncol. 2010;17:2847–55.en_US
dc.relation.referencesdoi: 10.1245/s10434-010-1158-1en_US
dc.relation.referencesCelen O, Yildirim E, Berberoglu U. Prognostic impact of positive lymph node ratio in gastric carcinoma. J Surg Oncol. 2007;62:95–101.en_US
dc.relation.referencesdoi: 10.1002/jso.20797en_US
dc.relation.referencesSlidell MB, Chang DC, Cameron JL, et al. Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis. Ann Surg Oncol. 2008;15:165–74.en_US
dc.relation.referencesdoi: 10.1245/s10434-007-9587-1en_US
dc.relation.referencesDekker JW, Peeters KC, Putter H, Vahrmeijer AL, van de Velde CJ. Metastatic lymph node ratio in stage III rectal cancer: prognostic significance in addition to the 7th edition of the TNM classification. Eur J Surg Oncol. 2010;36:1180–6.en_US
dc.relation.referencesdoi: 10.1016/j.ejso.2010.09.007en_US
dc.relation.referencesBeal SH, Chen SL, Schneider PD, Martinez SR. An evaluation of lymph node yield and lymph node ratio in well-differentiated thyroid carcinoma. Am Surg. 2010;76:28–32.en_US
dc.relation.referencesTakada H, Kikumori T, Imai T, Sawaki M, Shibata A, Kiuchi T. Patterns of lymph node metastases in papillary thyroid carcinoma: results from consecutive bilateral cervical lymph node dissection. World J Surg. 2011;35:1560–6.en_US
dc.relation.referencesdoi: 10.1007/s00268-011-1133-4en_US
dc.relation.referencesCooper DS, Doherty GM, Hauger BR, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214.en_US
dc.relation.referencesdoi: 10.1089/thy.2009.0110en_US
dc.relation.referencesLang BH, Lo CY, Chan WF, Lam KY, Wan KY. Staging systems for papillary thyroid carcinoma: a review and comparison. Ann Surg. 2007;245:366–78.en_US
dc.relation.referencesdoi: 10.1097/01.sla.0000250445.92336.2aen_US
dc.relation.referencesChan WF, Lang BH, Lo CY. The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a comparative study on 1000 nerves at risk. Surgery. 2006;140:866–73.en_US
dc.relation.referencesdoi: 10.1016/j.surg.2006.07.017en_US
dc.relation.referencesKim TY, Kim WB, Kim ES, et al. Serum thyroglobulin levels at the time of 131I remnant ablation just after thyroidectomy are useful for early prediction of clinical recurrence in low-risk patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2005;90:1440–5.en_US
dc.relation.referencesdoi: 10.1210/jc.2004-1771en_US
dc.relation.referencesHeemstra KA, Liu YY, Stokkel M, et al. Serum thyroglobulin concentrations predict disease-free remission and death in differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2007;66:58–64.en_US
dc.relation.referencesGiovanella L, Ceriani L, Suriano S, Ghelfo A, Maffioli M. Thyroglobulin measurement before rh-TSH-aided 131I ablation in detecting metastases form differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2008;69:659–63.en_US
dc.relation.referencesdoi: 10.1111/j.1365-2265.2008.03244.xen_US
dc.relation.referencesChung YS, Kim JY, Bae JS, et al. Lateral lymph node metastasis in papillary thyroid carcinoma: results of therapeutic lymph node dissection. Thyroid. 2009;19:241–6.en_US
dc.relation.referencesdoi: 10.1089/thy.2008.0244en_US
dc.relation.referencesKloos RT, Mazzaferri EL. A single recombinant human thyrotrophin–stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later. J Clin Endocrinol Metab. 2005;90:5047–57.en_US
dc.relation.referencesdoi: 10.1210/jc.2005-0492en_US
dc.relation.referencesCastagna MG, Brilli L, Pilli T, Montanaro A, Cipri C, Fioravanti C, Sestini F, Capezzone M, Pacini F. Limited value of repeat recombinant thyrotropin (rhTSH)-stimulated thyroglobulin testing in differentiated thyroid carcinoma patients with previous negative rhTSHstimulated thyroglobulin and undetectable basal serum thyroglobulin levels. J Clin Endocrinol Metab. 2008;93:76–81.en_US
dc.relation.referencesdoi: 10.1210/jc.2007-1404en_US
dc.relation.referencesSmallridge RC, Meek SE, Morgan MA, et al. Monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human TSH-stimulated thyroglobulin in follow-up of thyroid cancer patients. J Clin Endocrinol Metab. 2007;92:82–7.en_US
dc.relation.referencesdoi: 10.1210/jc.2006-0993en_US
dc.identifier.volume19-
dc.identifier.volume4-
dc.identifier.spage1257en_US
dc.identifier.epage1263en_US
dc.identifier.eissn1534-4681en_US
dc.identifier.isiWOS:000302698000030-
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.citeulike9916318-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats