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Article: Significance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissection
| Title | Significance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissection |
|---|---|
| Authors | |
| Keywords | Medicine & Public Health Surgical Oncology Oncology Surgery |
| Issue Date | 2012 |
| Publisher | Springer New York |
| Citation | Annals of Surgical Oncology, 2012, v. 19 n. 4 p. 1257-1263 How to Cite? |
| Abstract | Background: Prognostic significance of metastatic central lymph node ratio (CLNR) in papillary thyroid carcinoma (PTC) remains unknown. Because postsurgical detectable stimulated thyroglobulin (DsTg) after radioiodine ablation may imply persistent or recurrent disease, we evaluated the association between CLNR and rate of DsTg in patients with PTC who underwent unilateral prophylactic central neck dissection. Methods: To be eligible for analysis, the prophylactic central neck dissection specimen had to contain ≥3 central lymph nodes (CLNs) with ≥1 harboring metastasis. Of 129 specimens, 51 (39.5%) were eligible. CLNR was calculated as follows: (number of metastatic CLNs/number of CLNs retrieved) × 100. They were categorized into group 1 (CLNR 66.67%) (n = 22). Postablation sTg level was measured 6 months after radioiodine ablation. A multivariate analysis was conducted to identify factors for postablation DsTg. Results: Young age, palpable neck swelling, large tumor size, advanced tumor, node, metastasis system (TNM) stage, and large number of metastatic CLNs were significantly associated with high CLNR (P |
| Persistent Identifier | http://hdl.handle.net/10722/144942 |
| ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 1.037 |
| PubMed Central ID | |
| ISI Accession Number ID | |
| References | Lang BH, Lo CY, Chan WF, Lam KY, Wan KY. Prognostic factors in papillary and follicular thyroid carcinoma: implications for cancer staging. Ann Surg Oncol. 2007;14:730–8. doi: 10.1245/s10434-006-9207-5 Machens A, Hauptmann S, Dralle H. Lymph node dissection in the lateral neck for completion in central node-positive papillary thyroid cancer. Surgery. 2009;145:176–81. doi: 10.1016/j.surg.2008.09.003 Sywak M, Cornford L, Roach P, Stalberg P, Sidhu S, Delbridge L. Routine ipsilateral level VI lymphadenectomy reduces postoperative thyroglobulin levels in papillary thyroid carcinoma. Surgery. 2006;140:1000–7. doi: 10.1016/j.surg.2006.08.001 So YK, Seo MY, Son YI. Prophylactic central lymph nodes dissection for clinically node-negative papillary thyroid microcarcinoma: influence on serum thyroglobulin level, recurrence rate, and postoperative complication. Surgery. 2011. doi:10.1016/j.surgery.2011.02.004. Lang BH-H, Wong KP, Wan KY, Lo CY. Impact of routine unilateral central neck dissection on preablative and postablative stimulated thyroglobulin levels after total thyroidectomy in papillary thyroid carcinoma. Ann Surg Oncol. 2011. doi:10.1245/s10434-011-1833-x. Ceelen W, Van Nieuwenhove Y, Pattyn P. Prognostic value of the lymph node ratio in stage III colorectal cancer: a systematic review. Ann Surg Oncol. 2010;17:2847–55. doi: 10.1245/s10434-010-1158-1 Celen O, Yildirim E, Berberoglu U. Prognostic impact of positive lymph node ratio in gastric carcinoma. J Surg Oncol. 2007;62:95–101. doi: 10.1002/jso.20797 Slidell MB, Chang DC, Cameron JL, et al. Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis. Ann Surg Oncol. 2008;15:165–74. doi: 10.1245/s10434-007-9587-1 Dekker JW, Peeters KC, Putter H, Vahrmeijer AL, van de Velde CJ. Metastatic lymph node ratio in stage III rectal cancer: prognostic significance in addition to the 7th edition of the TNM classification. Eur J Surg Oncol. 2010;36:1180–6. doi: 10.1016/j.ejso.2010.09.007 Takada H, Kikumori T, Imai T, Sawaki M, Shibata A, Kiuchi T. Patterns of lymph node metastases in papillary thyroid carcinoma: results from consecutive bilateral cervical lymph node dissection. World J Surg. 2011;35:1560–6. doi: 10.1007/s00268-011-1133-4 Cooper DS, Doherty GM, Hauger BR, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214. doi: 10.1089/thy.2009.0110 Lang BH, Lo CY, Chan WF, Lam KY, Wan KY. Staging systems for papillary thyroid carcinoma: a review and comparison. Ann Surg. 2007;245:366–78. doi: 10.1097/01.sla.0000250445.92336.2a Chan WF, Lang BH, Lo CY. The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a comparative study on 1000 nerves at risk. Surgery. 2006;140:866–73. doi: 10.1016/j.surg.2006.07.017 Kim TY, Kim WB, Kim ES, et al. Serum thyroglobulin levels at the time of 131I remnant ablation just after thyroidectomy are useful for early prediction of clinical recurrence in low-risk patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2005;90:1440–5. doi: 10.1210/jc.2004-1771 Giovanella L, Ceriani L, Suriano S, Ghelfo A, Maffioli M. Thyroglobulin measurement before rh-TSH-aided 131I ablation in detecting metastases form differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2008;69:659–63. doi: 10.1111/j.1365-2265.2008.03244.x Chung YS, Kim JY, Bae JS, et al. Lateral lymph node metastasis in papillary thyroid carcinoma: results of therapeutic lymph node dissection. Thyroid. 2009;19:241–6. doi: 10.1089/thy.2008.0244 Kloos RT, Mazzaferri EL. A single recombinant human thyrotrophin–stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later. J Clin Endocrinol Metab. 2005;90:5047–57. doi: 10.1210/jc.2005-0492 Castagna MG, Brilli L, Pilli T, Montanaro A, Cipri C, Fioravanti C, Sestini F, Capezzone M, Pacini F. Limited value of repeat recombinant thyrotropin (rhTSH)-stimulated thyroglobulin testing in differentiated thyroid carcinoma patients with previous negative rhTSHstimulated thyroglobulin and undetectable basal serum thyroglobulin levels. J Clin Endocrinol Metab. 2008;93:76–81. doi: 10.1210/jc.2007-1404 Smallridge RC, Meek SE, Morgan MA, et al. Monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human TSH-stimulated thyroglobulin in follow-up of thyroid cancer patients. J Clin Endocrinol Metab. 2007;92:82–7. doi: 10.1210/jc.2006-0993 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lang, BHH | en_US |
| dc.contributor.author | Wong, KP | en_US |
| dc.contributor.author | Wan, KY | en_US |
| dc.contributor.author | Lo, CY | en_US |
| dc.date.accessioned | 2012-02-21T05:43:34Z | - |
| dc.date.available | 2012-02-21T05:43:34Z | - |
| dc.date.issued | 2012 | en_US |
| dc.identifier.citation | Annals of Surgical Oncology, 2012, v. 19 n. 4 p. 1257-1263 | en_US |
| dc.identifier.issn | 1068-9265 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/144942 | - |
| dc.description.abstract | Background: Prognostic significance of metastatic central lymph node ratio (CLNR) in papillary thyroid carcinoma (PTC) remains unknown. Because postsurgical detectable stimulated thyroglobulin (DsTg) after radioiodine ablation may imply persistent or recurrent disease, we evaluated the association between CLNR and rate of DsTg in patients with PTC who underwent unilateral prophylactic central neck dissection. Methods: To be eligible for analysis, the prophylactic central neck dissection specimen had to contain ≥3 central lymph nodes (CLNs) with ≥1 harboring metastasis. Of 129 specimens, 51 (39.5%) were eligible. CLNR was calculated as follows: (number of metastatic CLNs/number of CLNs retrieved) × 100. They were categorized into group 1 (CLNR 66.67%) (n = 22). Postablation sTg level was measured 6 months after radioiodine ablation. A multivariate analysis was conducted to identify factors for postablation DsTg. Results: Young age, palpable neck swelling, large tumor size, advanced tumor, node, metastasis system (TNM) stage, and large number of metastatic CLNs were significantly associated with high CLNR (P | en_US |
| dc.language | eng | en_US |
| dc.publisher | Springer New York | en_US |
| dc.relation.ispartof | Annals of Surgical Oncology | en_US |
| dc.rights | The Author(s) | en_US |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | en_US |
| dc.subject | Medicine & Public Health | en_US |
| dc.subject | Surgical Oncology | en_US |
| dc.subject | Oncology | en_US |
| dc.subject | Surgery | en_US |
| dc.title | Significance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissection | en_US |
| dc.type | Article | en_US |
| dc.identifier.openurl | http://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Significance of Metastatic Lymph Node Ratio on Stimulated Thyroglobulin Levels in Papillary Thyroid Carcinoma after Prophylactic Unilateral Central Neck Dissection&title=Annals of Surgical Oncology&issn=10689265&date=2011-10-12& spage=1&authors=Brian Hung-Hin Lang, Kai Pun Wong, Koon Yat Wan, <i>et al.</i> | en_US |
| dc.identifier.email | Lang, BHH: blang@hkucc.hku.hk | - |
| dc.identifier.email | Lo, CY: cylo@hkucc.hku.hk | - |
| dc.description.nature | published_or_final_version | en_US |
| dc.identifier.doi | 10.1245/s10434-011-2105-5 | en_US |
| dc.identifier.pmid | 21989667 | - |
| dc.identifier.pmcid | PMC3309142 | - |
| dc.identifier.scopus | eid_2-s2.0-84862506505 | - |
| dc.identifier.hkuros | 248809 | - |
| dc.identifier.hkuros | 197737 | - |
| dc.relation.references | Hong Kong Cancer Registry. Cancer incidence and mortality in Hong Kong, 1983–2006. http://www3.ha.org.hk/cancereg/e_stat.asp. | en_US |
| dc.relation.references | Lang BH, Lo CY, Chan WF, Lam KY, Wan KY. Prognostic factors in papillary and follicular thyroid carcinoma: implications for cancer staging. Ann Surg Oncol. 2007;14:730–8. | en_US |
| dc.relation.references | doi: 10.1245/s10434-006-9207-5 | en_US |
| dc.relation.references | Machens A, Hauptmann S, Dralle H. Lymph node dissection in the lateral neck for completion in central node-positive papillary thyroid cancer. Surgery. 2009;145:176–81. | en_US |
| dc.relation.references | doi: 10.1016/j.surg.2008.09.003 | en_US |
| dc.relation.references | Sywak M, Cornford L, Roach P, Stalberg P, Sidhu S, Delbridge L. Routine ipsilateral level VI lymphadenectomy reduces postoperative thyroglobulin levels in papillary thyroid carcinoma. Surgery. 2006;140:1000–7. | en_US |
| dc.relation.references | doi: 10.1016/j.surg.2006.08.001 | en_US |
| dc.relation.references | So YK, Seo MY, Son YI. Prophylactic central lymph nodes dissection for clinically node-negative papillary thyroid microcarcinoma: influence on serum thyroglobulin level, recurrence rate, and postoperative complication. Surgery. 2011. doi:10.1016/j.surgery.2011.02.004. | en_US |
| dc.relation.references | doi: 10.1016/j.surgery.2011.02.004 | en_US |
| dc.relation.references | Lang BH-H, Wong KP, Wan KY, Lo CY. Impact of routine unilateral central neck dissection on preablative and postablative stimulated thyroglobulin levels after total thyroidectomy in papillary thyroid carcinoma. Ann Surg Oncol. 2011. doi:10.1245/s10434-011-1833-x. | en_US |
| dc.relation.references | doi: 10.1245/s10434-011-1833-x | en_US |
| dc.relation.references | Ceelen W, Van Nieuwenhove Y, Pattyn P. Prognostic value of the lymph node ratio in stage III colorectal cancer: a systematic review. Ann Surg Oncol. 2010;17:2847–55. | en_US |
| dc.relation.references | doi: 10.1245/s10434-010-1158-1 | en_US |
| dc.relation.references | Celen O, Yildirim E, Berberoglu U. Prognostic impact of positive lymph node ratio in gastric carcinoma. J Surg Oncol. 2007;62:95–101. | en_US |
| dc.relation.references | doi: 10.1002/jso.20797 | en_US |
| dc.relation.references | Slidell MB, Chang DC, Cameron JL, et al. Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis. Ann Surg Oncol. 2008;15:165–74. | en_US |
| dc.relation.references | doi: 10.1245/s10434-007-9587-1 | en_US |
| dc.relation.references | Dekker JW, Peeters KC, Putter H, Vahrmeijer AL, van de Velde CJ. Metastatic lymph node ratio in stage III rectal cancer: prognostic significance in addition to the 7th edition of the TNM classification. Eur J Surg Oncol. 2010;36:1180–6. | en_US |
| dc.relation.references | doi: 10.1016/j.ejso.2010.09.007 | en_US |
| dc.relation.references | Beal SH, Chen SL, Schneider PD, Martinez SR. An evaluation of lymph node yield and lymph node ratio in well-differentiated thyroid carcinoma. Am Surg. 2010;76:28–32. | en_US |
| dc.relation.references | Takada H, Kikumori T, Imai T, Sawaki M, Shibata A, Kiuchi T. Patterns of lymph node metastases in papillary thyroid carcinoma: results from consecutive bilateral cervical lymph node dissection. World J Surg. 2011;35:1560–6. | en_US |
| dc.relation.references | doi: 10.1007/s00268-011-1133-4 | en_US |
| dc.relation.references | Cooper DS, Doherty GM, Hauger BR, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214. | en_US |
| dc.relation.references | doi: 10.1089/thy.2009.0110 | en_US |
| dc.relation.references | Lang BH, Lo CY, Chan WF, Lam KY, Wan KY. Staging systems for papillary thyroid carcinoma: a review and comparison. Ann Surg. 2007;245:366–78. | en_US |
| dc.relation.references | doi: 10.1097/01.sla.0000250445.92336.2a | en_US |
| dc.relation.references | Chan WF, Lang BH, Lo CY. The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a comparative study on 1000 nerves at risk. Surgery. 2006;140:866–73. | en_US |
| dc.relation.references | doi: 10.1016/j.surg.2006.07.017 | en_US |
| dc.relation.references | Kim TY, Kim WB, Kim ES, et al. Serum thyroglobulin levels at the time of 131I remnant ablation just after thyroidectomy are useful for early prediction of clinical recurrence in low-risk patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2005;90:1440–5. | en_US |
| dc.relation.references | doi: 10.1210/jc.2004-1771 | en_US |
| dc.relation.references | Heemstra KA, Liu YY, Stokkel M, et al. Serum thyroglobulin concentrations predict disease-free remission and death in differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2007;66:58–64. | en_US |
| dc.relation.references | Giovanella L, Ceriani L, Suriano S, Ghelfo A, Maffioli M. Thyroglobulin measurement before rh-TSH-aided 131I ablation in detecting metastases form differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2008;69:659–63. | en_US |
| dc.relation.references | doi: 10.1111/j.1365-2265.2008.03244.x | en_US |
| dc.relation.references | Chung YS, Kim JY, Bae JS, et al. Lateral lymph node metastasis in papillary thyroid carcinoma: results of therapeutic lymph node dissection. Thyroid. 2009;19:241–6. | en_US |
| dc.relation.references | doi: 10.1089/thy.2008.0244 | en_US |
| dc.relation.references | Kloos RT, Mazzaferri EL. A single recombinant human thyrotrophin–stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later. J Clin Endocrinol Metab. 2005;90:5047–57. | en_US |
| dc.relation.references | doi: 10.1210/jc.2005-0492 | en_US |
| dc.relation.references | Castagna MG, Brilli L, Pilli T, Montanaro A, Cipri C, Fioravanti C, Sestini F, Capezzone M, Pacini F. Limited value of repeat recombinant thyrotropin (rhTSH)-stimulated thyroglobulin testing in differentiated thyroid carcinoma patients with previous negative rhTSHstimulated thyroglobulin and undetectable basal serum thyroglobulin levels. J Clin Endocrinol Metab. 2008;93:76–81. | en_US |
| dc.relation.references | doi: 10.1210/jc.2007-1404 | en_US |
| dc.relation.references | Smallridge RC, Meek SE, Morgan MA, et al. Monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human TSH-stimulated thyroglobulin in follow-up of thyroid cancer patients. J Clin Endocrinol Metab. 2007;92:82–7. | en_US |
| dc.relation.references | doi: 10.1210/jc.2006-0993 | en_US |
| dc.identifier.volume | 19 | - |
| dc.identifier.issue | 4 | - |
| dc.identifier.spage | 1257 | en_US |
| dc.identifier.epage | 1263 | en_US |
| dc.identifier.eissn | 1534-4681 | en_US |
| dc.identifier.isi | WOS:000302698000030 | - |
| dc.description.other | Springer Open Choice, 21 Feb 2012 | en_US |
| dc.identifier.citeulike | 9916318 | - |
| dc.identifier.issnl | 1068-9265 | - |