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Article: Risk factors for nonsynchronous second primary malignancy and related death in patients with differentiated thyroid carcinoma

TitleRisk factors for nonsynchronous second primary malignancy and related death in patients with differentiated thyroid carcinoma
Authors
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals of Surgical Oncology, 2011, v. 18 n. 13, p. 3559-3565 How to Cite?
AbstractBACKGROUND: Differentiated thyroid cancer (DTC) survivors are at increased risk of developing nonsynchronous second primary malignancy (NSPM). This study aims to examine possible risk factors leading to occurrence of NSPM as well as risk factors leading to NSPM-related death in patients with DTC. METHODS: Of the 1,106 patients with DTC managed at our institution, 92 (8.3%) patients developed NSPM and 40 (3.6%) patients died of NSPM. All causes of death were confirmed by medical record, autopsy report or death certificate. Clinicopathological variables were compared between those without NSPM and with NSPM as well as between those who died of NSPM and did not die of NSPM. Significant variables on univariate analysis were entered into a Cox proportional hazards model. RESULTS: The median latency period from diagnosis of DTC to NSPM was 142.7 (range 16.8-511.0) months. For occurrence of NSPM, age at DTC diagnosis >/=50 years old [relative risk (RR) = 2.35], cumulative radioactive iodine (RAI) activity 3.0-8.9 GBq (RR = 2.38), and external local radiotherapy (ERT) (RR = 1.95) were significant risk factors. For NSPM-related death, age at DTC diagnosis >/=50 years old (RR = 3.32) and nonbreast cancer (RR = 5.76) were significant risk factors. CONCLUSIONS: NSPM accounted for 18.7% of all deaths in DTC, but mortality was high (43.5%). Age at DTC diagnosis >/=50 years old, cumulative RAI activity 3.0-8.9 GBq, and ERT were significant risk factors for occurrence of NSPM, whereas age at DTC diagnosis >/=50 years old and the diagnosis of nonbreast cancer were significant risk factors for NSPM-related death.
Persistent Identifierhttp://hdl.handle.net/10722/144916
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, BHHen_US
dc.contributor.authorWong, KPen_US
dc.date.accessioned2012-02-21T05:42:24Z-
dc.date.available2012-02-21T05:42:24Z-
dc.date.issued2011en_US
dc.identifier.citationAnnals of Surgical Oncology, 2011, v. 18 n. 13, p. 3559-3565en_US
dc.identifier.issn1068-9265en_US
dc.identifier.urihttp://hdl.handle.net/10722/144916-
dc.description.abstractBACKGROUND: Differentiated thyroid cancer (DTC) survivors are at increased risk of developing nonsynchronous second primary malignancy (NSPM). This study aims to examine possible risk factors leading to occurrence of NSPM as well as risk factors leading to NSPM-related death in patients with DTC. METHODS: Of the 1,106 patients with DTC managed at our institution, 92 (8.3%) patients developed NSPM and 40 (3.6%) patients died of NSPM. All causes of death were confirmed by medical record, autopsy report or death certificate. Clinicopathological variables were compared between those without NSPM and with NSPM as well as between those who died of NSPM and did not die of NSPM. Significant variables on univariate analysis were entered into a Cox proportional hazards model. RESULTS: The median latency period from diagnosis of DTC to NSPM was 142.7 (range 16.8-511.0) months. For occurrence of NSPM, age at DTC diagnosis >/=50 years old [relative risk (RR) = 2.35], cumulative radioactive iodine (RAI) activity 3.0-8.9 GBq (RR = 2.38), and external local radiotherapy (ERT) (RR = 1.95) were significant risk factors. For NSPM-related death, age at DTC diagnosis >/=50 years old (RR = 3.32) and nonbreast cancer (RR = 5.76) were significant risk factors. CONCLUSIONS: NSPM accounted for 18.7% of all deaths in DTC, but mortality was high (43.5%). Age at DTC diagnosis >/=50 years old, cumulative RAI activity 3.0-8.9 GBq, and ERT were significant risk factors for occurrence of NSPM, whereas age at DTC diagnosis >/=50 years old and the diagnosis of nonbreast cancer were significant risk factors for NSPM-related death.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.orgen_US
dc.relation.ispartofAnnals of Surgical Oncologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.rightsThe original publication is available at www.springerlink.comen_US
dc.subject.meshAdenocarcinoma, Follicular - complications - mortality-
dc.subject.meshCarcinoma, Papillary - complications - mortality-
dc.subject.meshCell Differentiation-
dc.subject.meshNeoplasms, Second Primary - etiology - mortality-
dc.subject.meshThyroid Neoplasms - complications - mortality-
dc.titleRisk factors for nonsynchronous second primary malignancy and related death in patients with differentiated thyroid carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLang, BHH: blang@hkucc.hku.hk-
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1245/s10434-011-1777-1en_US
dc.identifier.pmid21573833-
dc.identifier.pmcidPMC3222830-
dc.identifier.scopuseid_2-s2.0-82955233589en_US
dc.identifier.hkuros187590-
dc.identifier.volume18en_US
dc.identifier.issue13en_US
dc.identifier.spage3559en_US
dc.identifier.epage3565en_US
dc.identifier.eissn1534-4681en_US
dc.identifier.isiWOS:000297358900007-
dc.publisher.placeUnited States-
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.citeulike9326125-

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