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Article: Bone mineral density enhances use of clinical risk factors in predicting ten-year risk of osteoporotic fractures in Chinese men: The Hong Kong Osteoporosis Study

TitleBone mineral density enhances use of clinical risk factors in predicting ten-year risk of osteoporotic fractures in Chinese men: The Hong Kong Osteoporosis Study
Authors
KeywordsBone mineral density
Fracture risk
FRAX
Men
Osteoporosis
Osteoporotic fractures
Issue Date2011
PublisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198
Citation
Osteoporosis International, 2011, v. 22 n. 11, p. 2799-2807 How to Cite?
AbstractThis prospective study aimed to determine the risk factors and the 10-year probability of osteoporotic fracture in Southern Chinese men. The findings show substantial population differences in fracture incidence and risk prediction compared to the FRAX TM model, and the addition of BMD information to clinical risk factor assessment improved fracture risk prediction in Chinese men. Introduction: Clinical risk factors with or without bone mineral density (BMD) measurements are increasingly recognized as reliable predictors of fracture risk. Prospective data on fracture incidence in Asian men remain sparse. This prospective study aimed to determine the risk factors and the 10-year absolute fracture risk in Southern Chinese men. Methods: This is a part of the Hong Kong Osteoporosis Study. One thousand eight hundred ten (1,810) community-dwelling, treatment-naive men aged 50 years or above were evaluated. Baseline demographic characteristics, clinical risk factors and BMD were recorded. Ten-year risk of osteoporotic fracture was calculated using Cox proportional hazards models. Results: The mean age of subjects was 68.0 ± 10.3 years. After a mean follow-up period of 3.5±2.9 years (range 1 to 14 years), 37 incident low-trauma fractures were recorded. The incidence for all osteoporotic fractures and hip fractures was 635/100,000 and 123/100,000 person-years, respectively. The most significant predictors of osteoporotic fracture were history of fall (RR 14.5), femoral neck BMD T-score < -2.5 (RR 13.8) and history of fracture (RR 4.4). Each SD reduction in BMD was associated with a 1.8 to 2.6-fold increase in fracture risk. Subjects with seven clinical risk factors and BMD T-score of -1 had an absolute 10-year risk of osteoporotic fracture of 8.9%, but this increased to 22.7% if they also had a femoral neck BMD T-score of -2.5. Conclusions: These findings show substantial population differences in fracture incidence and risk prediction. The addition of BMD information to clinical risk factor assessment improved fracture risk prediction in Chinese men. © 2011 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/144874
ISSN
2015 Impact Factor: 3.445
2015 SCImago Journal Rankings: 1.460
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong University Foundation
University of Hong Kong
Funding Information:

This study was supported by the Bone Health Fund of the Hong Kong University Foundation and Osteoporosis Research Fund of the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorBow, CHen_HK
dc.contributor.authorTsang, SWYen_HK
dc.contributor.authorLoong, CHNen_HK
dc.contributor.authorSoong, CSSen_HK
dc.contributor.authorYeung, SCen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2012-02-21T05:43:41Z-
dc.date.available2012-02-21T05:43:41Z-
dc.date.issued2011en_HK
dc.identifier.citationOsteoporosis International, 2011, v. 22 n. 11, p. 2799-2807en_HK
dc.identifier.issn0937-941Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/144874-
dc.description.abstractThis prospective study aimed to determine the risk factors and the 10-year probability of osteoporotic fracture in Southern Chinese men. The findings show substantial population differences in fracture incidence and risk prediction compared to the FRAX TM model, and the addition of BMD information to clinical risk factor assessment improved fracture risk prediction in Chinese men. Introduction: Clinical risk factors with or without bone mineral density (BMD) measurements are increasingly recognized as reliable predictors of fracture risk. Prospective data on fracture incidence in Asian men remain sparse. This prospective study aimed to determine the risk factors and the 10-year absolute fracture risk in Southern Chinese men. Methods: This is a part of the Hong Kong Osteoporosis Study. One thousand eight hundred ten (1,810) community-dwelling, treatment-naive men aged 50 years or above were evaluated. Baseline demographic characteristics, clinical risk factors and BMD were recorded. Ten-year risk of osteoporotic fracture was calculated using Cox proportional hazards models. Results: The mean age of subjects was 68.0 ± 10.3 years. After a mean follow-up period of 3.5±2.9 years (range 1 to 14 years), 37 incident low-trauma fractures were recorded. The incidence for all osteoporotic fractures and hip fractures was 635/100,000 and 123/100,000 person-years, respectively. The most significant predictors of osteoporotic fracture were history of fall (RR 14.5), femoral neck BMD T-score < -2.5 (RR 13.8) and history of fracture (RR 4.4). Each SD reduction in BMD was associated with a 1.8 to 2.6-fold increase in fracture risk. Subjects with seven clinical risk factors and BMD T-score of -1 had an absolute 10-year risk of osteoporotic fracture of 8.9%, but this increased to 22.7% if they also had a femoral neck BMD T-score of -2.5. Conclusions: These findings show substantial population differences in fracture incidence and risk prediction. The addition of BMD information to clinical risk factor assessment improved fracture risk prediction in Chinese men. © 2011 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198en_HK
dc.relation.ispartofOsteoporosis Internationalen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectBone mineral densityen_HK
dc.subjectFracture risken_HK
dc.subjectFRAXen_HK
dc.subjectMenen_HK
dc.subjectOsteoporosisen_HK
dc.subjectOsteoporotic fracturesen_HK
dc.titleBone mineral density enhances use of clinical risk factors in predicting ten-year risk of osteoporotic fractures in Chinese men: The Hong Kong Osteoporosis Studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Bone mineral density enhances use of clinical risk factors in predicting ten-year risk of osteoporotic fractures in Chinese men: the Hong Kong Osteoporosis Study&title=Osteoporosis International&issn=0937941X&date=2011-11-01&volume=22&issue=11& spage=2799&authors=C. H. Bow, S. W. Y. Tsang, C. H. N. Loong, <i>et al.</i>en_US
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s00198-010-1490-0en_HK
dc.identifier.pmid21234548-
dc.identifier.pmcidPMC3186888-
dc.identifier.scopuseid_2-s2.0-80755128963en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80755128963&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2799en_HK
dc.identifier.epage2807en_HK
dc.identifier.eissn1433-2965en_US
dc.identifier.isiWOS:000297201000004-
dc.publisher.placeUnited Kingdomen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridBow, CH=36055977600en_HK
dc.identifier.scopusauthoridTsang, SWY=35182014900en_HK
dc.identifier.scopusauthoridLoong, CHN=36768353300en_HK
dc.identifier.scopusauthoridSoong, CSS=36769165800en_HK
dc.identifier.scopusauthoridYeung, SC=35958996000en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.citeulike8670919-

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