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Article: Promises of stem cell therapy for retinal degenerative diseases

TitlePromises of stem cell therapy for retinal degenerative diseases
Authors
KeywordsClinical applications
Donor cells
Method of cell delivery
Potential risks
Retinal degenerative diseases
Stem cell therapy
Target cell types
Issue Date2011
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htm
Citation
Graefe's Archive For Clinical And Experimental Ophthalmology, 2011, v. 249 n. 10, p. 1439-1448 How to Cite?
AbstractWith the development of stem cell technology, stem cell-based therapy for retinal degeneration has been proposed to restore the visual function. Many animal studies and some clinical trials have shown encouraging results of stem cell-based therapy in retinal degenerative diseases. While stem cell-based therapy is a promising strategy to replace damaged retinal cells and ultimately cure retinal degeneration, there are several important challenges which need to be overcome before stem cell technology can be applied widely in clinical settings. In this review, different types of donor cell origins used in retinal treatments, potential target cell types for therapy, methods of stem cell delivery to the eye, assessments of potential risks in stem cell therapy, as well as future developments of retinal stem cells therapy, will be discussed.
Persistent Identifierhttp://hdl.handle.net/10722/144872
ISSN
2015 Impact Factor: 1.991
2015 SCImago Journal Rankings: 1.217
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
NSFC/RGCN_HKU 716/09
University of Hong Kong201007176100
Funding Information:

This work was supported by NSFC/RGC Joint Research Scheme (N_HKU 716/09 to Q Lian) and Small project funding from the University of Hong Kong (201007176100 to Q Lian).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorWong, IYHen_HK
dc.contributor.authorPoon, MWen_HK
dc.contributor.authorPang, RTWen_HK
dc.contributor.authorLian, Qen_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2012-02-21T05:43:43Z-
dc.date.available2012-02-21T05:43:43Z-
dc.date.issued2011en_HK
dc.identifier.citationGraefe's Archive For Clinical And Experimental Ophthalmology, 2011, v. 249 n. 10, p. 1439-1448en_HK
dc.identifier.issn0721-832Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/144872-
dc.description.abstractWith the development of stem cell technology, stem cell-based therapy for retinal degeneration has been proposed to restore the visual function. Many animal studies and some clinical trials have shown encouraging results of stem cell-based therapy in retinal degenerative diseases. While stem cell-based therapy is a promising strategy to replace damaged retinal cells and ultimately cure retinal degeneration, there are several important challenges which need to be overcome before stem cell technology can be applied widely in clinical settings. In this review, different types of donor cell origins used in retinal treatments, potential target cell types for therapy, methods of stem cell delivery to the eye, assessments of potential risks in stem cell therapy, as well as future developments of retinal stem cells therapy, will be discussed.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htmen_HK
dc.relation.ispartofGraefe's Archive for Clinical and Experimental Ophthalmologyen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectClinical applicationsen_HK
dc.subjectDonor cellsen_HK
dc.subjectMethod of cell deliveryen_HK
dc.subjectPotential risksen_HK
dc.subjectRetinal degenerative diseasesen_HK
dc.subjectStem cell therapyen_HK
dc.subjectTarget cell typesen_HK
dc.titlePromises of stem cell therapy for retinal degenerative diseasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Promises of stem cell therapy for retinal degenerative diseases&title=Graefe's Archive for Clinical and Experimental Ophthalmology&issn=0721832X&date=2011-10-01&volume=249&issue=10& spage=1439&authors=Ian Yat-Hin Wong, Ming-Wai Poon, Rosita Tsz-Wai Pang, <i>et al.</i>en_US
dc.identifier.emailWong, IYH: wongyhi@hku.hken_HK
dc.identifier.emailLian, Q: qzlian@hkucc.hku.hken_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, IYH=rp01467en_HK
dc.identifier.authorityLian, Q=rp00267en_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s00417-011-1764-zen_HK
dc.identifier.pmid21866334-
dc.identifier.pmcidPMC3178027-
dc.identifier.scopuseid_2-s2.0-80755172142en_HK
dc.identifier.hkuros197807-
dc.identifier.hkuros197719-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80755172142&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume249en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1439en_HK
dc.identifier.epage1448en_HK
dc.identifier.eissn1435-702Xen_US
dc.identifier.isiWOS:000295129000002-
dc.publisher.placeGermanyen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.relation.projectGeneration of corneal epithelial stem cells from human induced pluripotent stem cells (iPSC) and application for corneal epithelial tissue engineering-
dc.identifier.scopusauthoridWong, IYH=36490557200en_HK
dc.identifier.scopusauthoridPoon, MW=54584072400en_HK
dc.identifier.scopusauthoridPang, RTW=54584075200en_HK
dc.identifier.scopusauthoridLian, Q=7003399023en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.citeulike9768635-

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