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Article: Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave

TitlePhysiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave
Authors
KeywordsAcoustic wave
Acupuncture
Ca 2+ ion channel
Endothelial cells
Fibroblast
Human
Mice
MRE
Issue Date2011
PublisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00424/index.htm
Citation
Pflugers Archiv European Journal Of Physiology, 2011, v. 462 n. 4, p. 587-597 How to Cite?
AbstractThis article presents a novel model of acupuncture physiology based on cellular calcium activation by an acoustic shear wave (ASW) generated by the mechanical movement of the needle. An acupuncture needle was driven by a piezoelectric transducer at 100 Hz or below, and the ASW in human calf was imaged by magnetic resonance elastography. At the cell level, the ASW activated intracellular Ca 2+ transients and oscillations in fibroblasts and endothelial, ventricular myocytes and neuronal PC-12 cells along with frequency-amplitude tuning and memory capabilities. Monitoring in vivo mammalian experiments with ASW, enhancement of endorphin in blood plasma and blocking by Gd 3+ were observed; and increased Ca 2+ fluorescence in mouse hind leg muscle was imaged by two-photon microscopy. In contrast with traditional acupuncture models, the signal source is derived from the total acoustic energy. ASW signaling makes use of the anisotropy of elasticity of tissues as its waveguides for transmission and that cell activation is not based on the nervous system. © 2011 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/144866
ISSN
2015 Impact Factor: 3.654
2015 SCImago Journal Rankings: 1.638
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
HK Jockey Club
HKU Foundation
Funding Information:

In memory of Professor Sir Harry Fang, MD, whose counsel, confidence, and unfailing support made this research possible. ESY would also like to thank Dr. Allan Wong for his extraordinary kindness and support during his sojourn in Hong Kong. Generous with his time and ideas, Dr. Peace Cheng (Peking U) made suggestions in cell line studies and helped supervise J. Liang. The assistance of A. Kwan (CUHK) and W. J. Xie (PKU) in cell line experiments is gratefully acknowledged. Early funding was provided by HK Jockey Club and HKU Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Gen_HK
dc.contributor.authorLiang, JMen_HK
dc.contributor.authorLi, PWen_HK
dc.contributor.authorYao, Xen_HK
dc.contributor.authorPei, PZen_HK
dc.contributor.authorLi, Wen_HK
dc.contributor.authorHe, QHen_HK
dc.contributor.authorYang, Xen_HK
dc.contributor.authorChan, QCCen_HK
dc.contributor.authorCheung, PYSen_HK
dc.contributor.authorMa, QYen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorCheng, PYCen_HK
dc.contributor.authorYang, ESen_HK
dc.date.accessioned2012-02-21T05:44:40Z-
dc.date.available2012-02-21T05:44:40Z-
dc.date.issued2011en_HK
dc.identifier.citationPflugers Archiv European Journal Of Physiology, 2011, v. 462 n. 4, p. 587-597en_HK
dc.identifier.issn0031-6768en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144866-
dc.description.abstractThis article presents a novel model of acupuncture physiology based on cellular calcium activation by an acoustic shear wave (ASW) generated by the mechanical movement of the needle. An acupuncture needle was driven by a piezoelectric transducer at 100 Hz or below, and the ASW in human calf was imaged by magnetic resonance elastography. At the cell level, the ASW activated intracellular Ca 2+ transients and oscillations in fibroblasts and endothelial, ventricular myocytes and neuronal PC-12 cells along with frequency-amplitude tuning and memory capabilities. Monitoring in vivo mammalian experiments with ASW, enhancement of endorphin in blood plasma and blocking by Gd 3+ were observed; and increased Ca 2+ fluorescence in mouse hind leg muscle was imaged by two-photon microscopy. In contrast with traditional acupuncture models, the signal source is derived from the total acoustic energy. ASW signaling makes use of the anisotropy of elasticity of tissues as its waveguides for transmission and that cell activation is not based on the nervous system. © 2011 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00424/index.htmen_HK
dc.relation.ispartofPflugers Archiv European Journal of Physiologyen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectAcoustic waveen_HK
dc.subjectAcupunctureen_HK
dc.subjectCa 2+ ion channelen_HK
dc.subjectEndothelial cellsen_HK
dc.subjectFibroblasten_HK
dc.subjectHumanen_HK
dc.subjectMiceen_HK
dc.subjectMREen_HK
dc.subject.meshAcoustic Stimulation-
dc.subject.meshAcupuncture Therapy-
dc.subject.meshCalcium Signaling - physiology-
dc.subject.meshMuscle, Skeletal - physiology-
dc.subject.meshElasticity Imaging Techniques-
dc.titlePhysiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear waveen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave&title=Pflügers Archiv European Journal of Physiology&issn=00316768&date=2011-10-01&volume=462&issue=4& spage=587&authors=Geng Li, Jie-Ming Liang, Pei-Wen Li, <i>et al.</i>en_US
dc.identifier.emailCheung, PYS:paul.cheung@hku.hken_HK
dc.identifier.emailYang, ES:esyang@hkueee.hku.hken_HK
dc.identifier.authorityCheung, PYS=rp00077en_HK
dc.identifier.authorityYang, ES=rp00199en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s00424-011-0993-7en_HK
dc.identifier.pmid21796340-
dc.identifier.pmcidPMC3170465-
dc.identifier.scopuseid_2-s2.0-80054744181en_HK
dc.identifier.hkuros194074-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054744181&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume462en_HK
dc.identifier.issue4en_HK
dc.identifier.spage587en_HK
dc.identifier.epage597en_HK
dc.identifier.eissn1432-2013en_US
dc.identifier.isiWOS:000299152700008-
dc.publisher.placeGermanyen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridLi, G=35767974200en_HK
dc.identifier.scopusauthoridLiang, JM=26321836100en_HK
dc.identifier.scopusauthoridLi, PW=24329872200en_HK
dc.identifier.scopusauthoridYao, X=7402529434en_HK
dc.identifier.scopusauthoridPei, PZ=54389801900en_HK
dc.identifier.scopusauthoridLi, W=36066858500en_HK
dc.identifier.scopusauthoridHe, QH=7402117847en_HK
dc.identifier.scopusauthoridYang, X=23007172600en_HK
dc.identifier.scopusauthoridChan, QCC=6602497305en_HK
dc.identifier.scopusauthoridCheung, PYS=7202595335en_HK
dc.identifier.scopusauthoridMa, QY=54389448600en_HK
dc.identifier.scopusauthoridLam, SK=54389355800en_HK
dc.identifier.scopusauthoridCheng, PYC=36779050000en_HK
dc.identifier.scopusauthoridYang, ES=7202021229en_HK
dc.identifier.citeulike9684716-

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