Article: Acrolein scavengers: Reactivity, mechanism and impact on health

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TitleAcrolein scavengers: Reactivity, mechanism and impact on health
AuthorsZhu, Q1
Sun, Z1
Jiang, Y2
Chen, F1 3
Wang, M1
KeywordsAcrolein
Antioxidants
Lipid peroxidation
Scavengers
Issue Date2011
PublisherWiley - V C H Verlag GmbH & Co KGaA.
CitationMolecular Nutrition And Food Research, 2011, v. 55 n. 9, p. 1375-1390 [How to Cite?]
DOI: http://dx.doi.org/10.1002/mnfr.201100149
AbstractAcrolein (ACR) is an α,β-unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. It can also be generated through endogenous metabolism. Its high electrophilicity makes this aldehyde notorious for its facile reaction with biological nucleophiles, leading to the modification of proteins/DNA and depletion of glutathione. Recent studies also have revealed its roles in disturbing various cell signing pathways in biological systems. With growing evidences of ACR's implication in human diseases, strategies to eliminate its hazardous impacts are of great importance. One of the intervention strategies is the application of reactive scavengers to directly trap ACR. Some known ACR scavengers include sulfur (thiol)-containing and nitrogen (amino)-containing compounds as well as the newly emerging natural polyphenols. In this review, the interactions between ACR and its scavengers are highlighted. The discussion about ACR scavengers is mainly focused on their chemical reactivity, trapping mechanisms as well as their roles extended to biological relevance. In addition to their direct trapping effect on ACR, these scavengers might possess multiple functions and offer additional benefits against ACR-induced toxicity. A comprehensive understanding of the mechanism involved may help to establish ACR scavenging as a novel therapeutic intervention against human diseases that are associated with ACR and/or oxidative stress. © 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
ISSN1613-4125
2011 Impact Factor: 4.301
2011 SCImago Journal Rankings: 0.279
DOIhttp://dx.doi.org/10.1002/mnfr.201100149
ISI Accession Number IDWOS:000295692800009
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZhu, Q
dc.contributor.authorSun, Z
dc.contributor.authorJiang, Y
dc.contributor.authorChen, F
dc.contributor.authorWang, M
dc.date.accessioned2012-02-03T06:20:08Z
dc.date.available2012-02-03T06:20:08Z
dc.date.issued2011
dc.description.abstractAcrolein (ACR) is an α,β-unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. It can also be generated through endogenous metabolism. Its high electrophilicity makes this aldehyde notorious for its facile reaction with biological nucleophiles, leading to the modification of proteins/DNA and depletion of glutathione. Recent studies also have revealed its roles in disturbing various cell signing pathways in biological systems. With growing evidences of ACR's implication in human diseases, strategies to eliminate its hazardous impacts are of great importance. One of the intervention strategies is the application of reactive scavengers to directly trap ACR. Some known ACR scavengers include sulfur (thiol)-containing and nitrogen (amino)-containing compounds as well as the newly emerging natural polyphenols. In this review, the interactions between ACR and its scavengers are highlighted. The discussion about ACR scavengers is mainly focused on their chemical reactivity, trapping mechanisms as well as their roles extended to biological relevance. In addition to their direct trapping effect on ACR, these scavengers might possess multiple functions and offer additional benefits against ACR-induced toxicity. A comprehensive understanding of the mechanism involved may help to establish ACR scavenging as a novel therapeutic intervention against human diseases that are associated with ACR and/or oxidative stress. © 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationMolecular Nutrition And Food Research, 2011, v. 55 n. 9, p. 1375-1390 [How to Cite?]
DOI: http://dx.doi.org/10.1002/mnfr.201100149
dc.identifier.doihttp://dx.doi.org/10.1002/mnfr.201100149
dc.identifier.epage1390
dc.identifier.hkuros198289
dc.identifier.isiWOS:000295692800009
dc.identifier.issn1613-4125
2011 Impact Factor: 4.301
2011 SCImago Journal Rankings: 0.279
dc.identifier.issue9
dc.identifier.pmid21714129
dc.identifier.scopuseid_2-s2.0-80052525395
dc.identifier.spage1375
dc.identifier.urihttp://hdl.handle.net/10722/144726
dc.identifier.volume55
dc.languageeng
dc.publisherWiley - V C H Verlag GmbH & Co KGaA.
dc.publisher.placeGermany
dc.relation.ispartofMolecular Nutrition and Food Research
dc.relation.referencesReferences in Scopus
dc.rightsPreprint This is the pre-peer reviewed version of the following article: FULL CITE, which has been published in final form at [Link to final article].
dc.subject.meshAcrolein - chemistry - toxicity
dc.subject.meshAscorbic Acid - chemistry - pharmacology
dc.subject.meshGlutathione - metabolism
dc.subject.meshHydralazine - chemistry - pharmacology
dc.subject.meshPharmaceutical Preparations - chemistry
dc.subjectAcrolein
dc.subjectAntioxidants
dc.subjectLipid peroxidation
dc.subjectScavengers
dc.titleAcrolein scavengers: Reactivity, mechanism and impact on health
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong Baptist University
  3. Peking University