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Article: Acrolein scavengers: Reactivity, mechanism and impact on health

TitleAcrolein scavengers: Reactivity, mechanism and impact on health
Authors
KeywordsAcrolein
Antioxidants
Lipid peroxidation
Scavengers
Issue Date2011
PublisherWiley - V C H Verlag GmbH & Co KGaA.
Citation
Molecular Nutrition And Food Research, 2011, v. 55 n. 9, p. 1375-1390 How to Cite?
Abstract
Acrolein (ACR) is an α,β-unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. It can also be generated through endogenous metabolism. Its high electrophilicity makes this aldehyde notorious for its facile reaction with biological nucleophiles, leading to the modification of proteins/DNA and depletion of glutathione. Recent studies also have revealed its roles in disturbing various cell signing pathways in biological systems. With growing evidences of ACR's implication in human diseases, strategies to eliminate its hazardous impacts are of great importance. One of the intervention strategies is the application of reactive scavengers to directly trap ACR. Some known ACR scavengers include sulfur (thiol)-containing and nitrogen (amino)-containing compounds as well as the newly emerging natural polyphenols. In this review, the interactions between ACR and its scavengers are highlighted. The discussion about ACR scavengers is mainly focused on their chemical reactivity, trapping mechanisms as well as their roles extended to biological relevance. In addition to their direct trapping effect on ACR, these scavengers might possess multiple functions and offer additional benefits against ACR-induced toxicity. A comprehensive understanding of the mechanism involved may help to establish ACR scavenging as a novel therapeutic intervention against human diseases that are associated with ACR and/or oxidative stress. © 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/144726
ISSN
2013 Impact Factor: 4.909
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong Baptist University
  3. Peking University
DC FieldValueLanguage
dc.contributor.authorZhu, Qen_HK
dc.contributor.authorSun, Zen_HK
dc.contributor.authorJiang, Yen_HK
dc.contributor.authorChen, Fen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2012-02-03T06:20:08Z-
dc.date.available2012-02-03T06:20:08Z-
dc.date.issued2011en_HK
dc.identifier.citationMolecular Nutrition And Food Research, 2011, v. 55 n. 9, p. 1375-1390en_HK
dc.identifier.issn1613-4125en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144726-
dc.description.abstractAcrolein (ACR) is an α,β-unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. It can also be generated through endogenous metabolism. Its high electrophilicity makes this aldehyde notorious for its facile reaction with biological nucleophiles, leading to the modification of proteins/DNA and depletion of glutathione. Recent studies also have revealed its roles in disturbing various cell signing pathways in biological systems. With growing evidences of ACR's implication in human diseases, strategies to eliminate its hazardous impacts are of great importance. One of the intervention strategies is the application of reactive scavengers to directly trap ACR. Some known ACR scavengers include sulfur (thiol)-containing and nitrogen (amino)-containing compounds as well as the newly emerging natural polyphenols. In this review, the interactions between ACR and its scavengers are highlighted. The discussion about ACR scavengers is mainly focused on their chemical reactivity, trapping mechanisms as well as their roles extended to biological relevance. In addition to their direct trapping effect on ACR, these scavengers might possess multiple functions and offer additional benefits against ACR-induced toxicity. A comprehensive understanding of the mechanism involved may help to establish ACR scavenging as a novel therapeutic intervention against human diseases that are associated with ACR and/or oxidative stress. © 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA.-
dc.relation.ispartofMolecular Nutrition and Food Researchen_HK
dc.rightsPreprint This is the pre-peer reviewed version of the following article: FULL CITE, which has been published in final form at [Link to final article].-
dc.subjectAcroleinen_HK
dc.subjectAntioxidantsen_HK
dc.subjectLipid peroxidationen_HK
dc.subjectScavengersen_HK
dc.subject.meshAcrolein - chemistry - toxicity-
dc.subject.meshAscorbic Acid - chemistry - pharmacology-
dc.subject.meshGlutathione - metabolism-
dc.subject.meshHydralazine - chemistry - pharmacology-
dc.subject.meshPharmaceutical Preparations - chemistry-
dc.titleAcrolein scavengers: Reactivity, mechanism and impact on healthen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M: mfwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00800en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mnfr.201100149en_HK
dc.identifier.pmid21714129en_HK
dc.identifier.scopuseid_2-s2.0-80052525395en_HK
dc.identifier.hkuros198289en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052525395&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume55en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1375en_HK
dc.identifier.epage1390en_HK
dc.identifier.isiWOS:000295692800009-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridZhu, Q=54909442800en_HK
dc.identifier.scopusauthoridSun, Z=22837137300en_HK
dc.identifier.scopusauthoridJiang, Y=24605346600en_HK
dc.identifier.scopusauthoridChen, F=35195539500en_HK
dc.identifier.scopusauthoridWang, M=7406691844en_HK

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