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Article: Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations

TitleGenome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations
Authors
Issue Date2012
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 2012, v. 44 n. 1, p. 62-66 How to Cite?
AbstractPancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10 -13 to P = 4.18 × 10 -10) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.
DescriptionLetters
Persistent Identifierhttp://hdl.handle.net/10722/144597
ISSN
2014 Impact Factor: 29.352
2014 SCImago Journal Rankings: 19.545
ISI Accession Number ID
Funding AgencyGrant Number
National High-Tech Research and Development Program of China2009AA022706
National Natural Science Foundation of China81021061
Funding Information:

This work was supported by grants from the National High-Tech Research and Development Program of China (2009AA022706) and the National Natural Science Foundation of China (81021061) to D. L. We thank L. Liang for help in eQTL analysis. We also thank the subjects and the surgeons who recruited them; M. Yang, L. Wang, X. Wang, C. Yang, L. Du, J. Li, F. Qi, X. Song and L. Zeng.

References

 

DC FieldValueLanguage
dc.contributor.authorWu, Cen_HK
dc.contributor.authorMiao, Xen_HK
dc.contributor.authorHuang, Len_HK
dc.contributor.authorChe, Xen_HK
dc.contributor.authorJiang, Gen_HK
dc.contributor.authorYu, Den_HK
dc.contributor.authorYang, Xen_HK
dc.contributor.authorCao, Gen_HK
dc.contributor.authorHu, Zen_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorZuo, Cen_HK
dc.contributor.authorWang, Cen_HK
dc.contributor.authorZhang, Xen_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorYu, Xen_HK
dc.contributor.authorDai, Wen_HK
dc.contributor.authorLi, Zen_HK
dc.contributor.authorShen, Hen_HK
dc.contributor.authorLiu, Len_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorZhang, Sen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorZhai, Ken_HK
dc.contributor.authorChang, Jen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorSun, Men_HK
dc.contributor.authorCao, Wen_HK
dc.contributor.authorGao, Jen_HK
dc.contributor.authorMa, Yen_HK
dc.contributor.authorZheng, Xen_HK
dc.contributor.authorCheung, STen_HK
dc.contributor.authorJia, Yen_HK
dc.contributor.authorXu, Jen_HK
dc.contributor.authorTan, Wen_HK
dc.contributor.authorZhao, Pen_HK
dc.contributor.authorWu, Ten_HK
dc.contributor.authorWang, Cen_HK
dc.contributor.authorLin, Den_HK
dc.date.accessioned2012-02-03T06:15:09Z-
dc.date.available2012-02-03T06:15:09Z-
dc.date.issued2012en_HK
dc.identifier.citationNature Genetics, 2012, v. 44 n. 1, p. 62-66en_HK
dc.identifier.issn1061-4036en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144597-
dc.descriptionLetters-
dc.description.abstractPancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10 -13 to P = 4.18 × 10 -10) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_HK
dc.relation.ispartofNature Geneticsen_HK
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenome-Wide Association Study-
dc.subject.meshPancreatic Neoplasms - genetics-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleGenome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populationsen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, X: xqwang@hkucc.hku.hken_HK
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_HK
dc.identifier.authorityWang, X=rp00507en_HK
dc.identifier.authorityCheung, ST=rp00457en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ng.1020en_HK
dc.identifier.pmid22158540en_HK
dc.identifier.scopuseid_2-s2.0-84655162046en_HK
dc.identifier.hkuros198366en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84655162046&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue1en_HK
dc.identifier.spage62en_HK
dc.identifier.epage66en_HK
dc.identifier.isiWOS:000298664000015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, C=16231904800en_HK
dc.identifier.scopusauthoridMiao, X=7102585391en_HK
dc.identifier.scopusauthoridHuang, L=8267905800en_HK
dc.identifier.scopusauthoridChe, X=7005743411en_HK
dc.identifier.scopusauthoridJiang, G=7401706807en_HK
dc.identifier.scopusauthoridYu, D=16302785600en_HK
dc.identifier.scopusauthoridYang, X=23494403100en_HK
dc.identifier.scopusauthoridCao, G=7401709911en_HK
dc.identifier.scopusauthoridHu, Z=8392216300en_HK
dc.identifier.scopusauthoridZhou, Y=54797226100en_HK
dc.identifier.scopusauthoridZuo, C=54797208000en_HK
dc.identifier.scopusauthoridWang, C=54797062800en_HK
dc.identifier.scopusauthoridZhang, X=54797231400en_HK
dc.identifier.scopusauthoridZhou, Y=12447009700en_HK
dc.identifier.scopusauthoridYu, X=7404114593en_HK
dc.identifier.scopusauthoridDai, W=54796522100en_HK
dc.identifier.scopusauthoridLi, Z=35769321700en_HK
dc.identifier.scopusauthoridShen, H=34873591800en_HK
dc.identifier.scopusauthoridLiu, L=54796813200en_HK
dc.identifier.scopusauthoridChen, Y=54796376100en_HK
dc.identifier.scopusauthoridZhang, S=54797198700en_HK
dc.identifier.scopusauthoridWang, X=17343159900en_HK
dc.identifier.scopusauthoridZhai, K=6603891848en_HK
dc.identifier.scopusauthoridChang, J=36626991100en_HK
dc.identifier.scopusauthoridLiu, Y=7410217637en_HK
dc.identifier.scopusauthoridSun, M=14833715200en_HK
dc.identifier.scopusauthoridCao, W=54796461800en_HK
dc.identifier.scopusauthoridGao, J=7404475314en_HK
dc.identifier.scopusauthoridMa, Y=8291567700en_HK
dc.identifier.scopusauthoridZheng, X=35742406300en_HK
dc.identifier.scopusauthoridCheung, ST=7202473497en_HK
dc.identifier.scopusauthoridJia, Y=54796725000en_HK
dc.identifier.scopusauthoridXu, J=54797073300en_HK
dc.identifier.scopusauthoridTan, W=7401959984en_HK
dc.identifier.scopusauthoridZhao, P=34869025400en_HK
dc.identifier.scopusauthoridWu, T=7404815278en_HK
dc.identifier.scopusauthoridWang, C=54797051400en_HK
dc.identifier.scopusauthoridLin, D=34668212600en_HK
dc.identifier.citeulike10179024-

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