Article: Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations
| Title | Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Wu, C8 Miao, X9 Huang, L8 Che, X6 Jiang, G10 Yu, D8 Yang, X1 Cao, G14 Hu, Z5 Zhou, Y13 Zuo, C7 Wang, C9 Zhang, X15 Zhou, Y11 Yu, X10 Dai, W1 Li, Z14 Shen, H5 Liu, L10 Chen, Y13 Zhang, S4 Wang, X3 Zhai, K8 Chang, J8 Liu, Y8 Sun, M10 Cao, W1 Gao, J14 Ma, Y1 Zheng, X12 Cheung, ST3 Jia, Y2 Xu, J8 Tan, W8 Zhao, P6 Wu, T9 Wang, C6 Lin, D8 | ||||||
| Issue Date | 2012 | ||||||
| Publisher | Nature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com | ||||||
| Citation | Nature Genetics, 2012, v. 44 n. 1, p. 62-66 [How to Cite?] DOI: http://dx.doi.org/10.1038/ng.1020 | ||||||
| Abstract | Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10 -13 to P = 4.18 × 10 -10) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. | ||||||
| Description | Letters | ||||||
| ISSN | 1061-4036 2011 Impact Factor: 35.532 2011 SCImago Journal Rankings: 8.923 | ||||||
| DOI | http://dx.doi.org/10.1038/ng.1020 | ||||||
| ISI Accession Number ID | WOS:000298664000015
Funding Information: This work was supported by grants from the National High-Tech Research and Development Program of China (2009AA022706) and the National Natural Science Foundation of China (81021061) to D. L. We thank L. Liang for help in eQTL analysis. We also thank the subjects and the surgeons who recruited them; M. Yang, L. Wang, X. Wang, C. Yang, L. Du, J. Li, F. Qi, X. Song and L. Zeng. | ||||||
| References | References in Scopus |
| dc.contributor.author | Wu, C | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Miao, X | ||||||
| dc.contributor.author | Huang, L | ||||||
| dc.contributor.author | Che, X | ||||||
| dc.contributor.author | Jiang, G | ||||||
| dc.contributor.author | Yu, D | ||||||
| dc.contributor.author | Yang, X | ||||||
| dc.contributor.author | Cao, G | ||||||
| dc.contributor.author | Hu, Z | ||||||
| dc.contributor.author | Zhou, Y | ||||||
| dc.contributor.author | Zuo, C | ||||||
| dc.contributor.author | Wang, C | ||||||
| dc.contributor.author | Zhang, X | ||||||
| dc.contributor.author | Zhou, Y | ||||||
| dc.contributor.author | Yu, X | ||||||
| dc.contributor.author | Dai, W | ||||||
| dc.contributor.author | Li, Z | ||||||
| dc.contributor.author | Shen, H | ||||||
| dc.contributor.author | Liu, L | ||||||
| dc.contributor.author | Chen, Y | ||||||
| dc.contributor.author | Zhang, S | ||||||
| dc.contributor.author | Wang, X | ||||||
| dc.contributor.author | Zhai, K | ||||||
| dc.contributor.author | Chang, J | ||||||
| dc.contributor.author | Liu, Y | ||||||
| dc.contributor.author | Sun, M | ||||||
| dc.contributor.author | Cao, W | ||||||
| dc.contributor.author | Gao, J | ||||||
| dc.contributor.author | Ma, Y | ||||||
| dc.contributor.author | Zheng, X | ||||||
| dc.contributor.author | Cheung, ST | ||||||
| dc.contributor.author | Jia, Y | ||||||
| dc.contributor.author | Xu, J | ||||||
| dc.contributor.author | Tan, W | ||||||
| dc.contributor.author | Zhao, P | ||||||
| dc.contributor.author | Wu, T | ||||||
| dc.contributor.author | Wang, C | ||||||
| dc.contributor.author | Lin, D | ||||||
| dc.date.accessioned | 2012-02-03T06:15:09Z | ||||||
| dc.date.available | 2012-02-03T06:15:09Z | ||||||
| dc.date.issued | 2012 | ||||||
| dc.description.abstract | Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10 -13 to P = 4.18 × 10 -10) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.description | Letters | ||||||
| dc.identifier.citation | Nature Genetics, 2012, v. 44 n. 1, p. 62-66 [How to Cite?] DOI: http://dx.doi.org/10.1038/ng.1020 | ||||||
| dc.identifier.citeulike | 10179024 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1038/ng.1020 | ||||||
| dc.identifier.epage | 66 | ||||||
| dc.identifier.hkuros | 198366 | ||||||
| dc.identifier.isi | WOS:000298664000015
Funding Information: This work was supported by grants from the National High-Tech Research and Development Program of China (2009AA022706) and the National Natural Science Foundation of China (81021061) to D. L. We thank L. Liang for help in eQTL analysis. We also thank the subjects and the surgeons who recruited them; M. Yang, L. Wang, X. Wang, C. Yang, L. Du, J. Li, F. Qi, X. Song and L. Zeng. | ||||||
| dc.identifier.issn | 1061-4036 2011 Impact Factor: 35.532 2011 SCImago Journal Rankings: 8.923 | ||||||
| dc.identifier.issue | 1 | ||||||
| dc.identifier.pmid | 22158540 | ||||||
| dc.identifier.scopus | eid_2-s2.0-84655162046 | ||||||
| dc.identifier.spage | 62 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/144597 | ||||||
| dc.identifier.volume | 44 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Nature Genetics | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Asian Continental Ancestry Group - genetics | ||||||
| dc.subject.mesh | Genetic Predisposition to Disease | ||||||
| dc.subject.mesh | Genome-Wide Association Study | ||||||
| dc.subject.mesh | Pancreatic Neoplasms - genetics | ||||||
| dc.subject.mesh | Polymorphism, Single Nucleotide | ||||||
| dc.title | Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations | ||||||
| dc.type | Article |
Author Affiliations
- China Medical University
- Affiliated Hospital
- The University of Hong Kong
- Fujian Medical University
- Nanjing Medical University
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Hunan Province Tumor Hospital
- Chinese Academy of Medical Sciences
- Huazhong University of Science and Technology
- Fudan University
- Soochow University
- Fujian Provincial Cancer Hospital
- Medical University
- Second Military Medical University
- Hebei Medical University