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Article: Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations
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TitleGenome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations
 
AuthorsWu, C8
Miao, X9
Huang, L8
Che, X6
Jiang, G11
Yu, D8
Yang, X2
Cao, G14
Hu, Z5
Zhou, Y12
Zuo, C7
Wang, C9
Zhang, X15
Zhou, Y10
Yu, X11
Dai, W2
Li, Z14
Shen, H5
Liu, L11
Chen, Y12
Zhang, S4
Wang, X3
Zhai, K8
Chang, J8
Liu, Y8
Sun, M11
Cao, W2
Gao, J14
Ma, Y2
Zheng, X13
Cheung, ST3
Jia, Y1
Xu, J8
Tan, W8
Zhao, P6
Wu, T9
Wang, C6
Lin, D8
 
Issue Date2012
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
 
CitationNature Genetics, 2012, v. 44 n. 1, p. 62-66 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ng.1020
 
AbstractPancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10 -13 to P = 4.18 × 10 -10) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.
 
DescriptionLetters
 
ISSN1061-4036
2012 Impact Factor: 35.209
2012 SCImago Journal Rankings: 20.421
 
DOIhttp://dx.doi.org/10.1038/ng.1020
 
ISI Accession Number IDWOS:000298664000015
Funding AgencyGrant Number
National High-Tech Research and Development Program of China2009AA022706
National Natural Science Foundation of China81021061
Funding Information:

This work was supported by grants from the National High-Tech Research and Development Program of China (2009AA022706) and the National Natural Science Foundation of China (81021061) to D. L. We thank L. Liang for help in eQTL analysis. We also thank the subjects and the surgeons who recruited them; M. Yang, L. Wang, X. Wang, C. Yang, L. Du, J. Li, F. Qi, X. Song and L. Zeng.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWu, C
 
dc.contributor.authorMiao, X
 
dc.contributor.authorHuang, L
 
dc.contributor.authorChe, X
 
dc.contributor.authorJiang, G
 
dc.contributor.authorYu, D
 
dc.contributor.authorYang, X
 
dc.contributor.authorCao, G
 
dc.contributor.authorHu, Z
 
dc.contributor.authorZhou, Y
 
dc.contributor.authorZuo, C
 
dc.contributor.authorWang, C
 
dc.contributor.authorZhang, X
 
dc.contributor.authorZhou, Y
 
dc.contributor.authorYu, X
 
dc.contributor.authorDai, W
 
dc.contributor.authorLi, Z
 
dc.contributor.authorShen, H
 
dc.contributor.authorLiu, L
 
dc.contributor.authorChen, Y
 
dc.contributor.authorZhang, S
 
dc.contributor.authorWang, X
 
dc.contributor.authorZhai, K
 
dc.contributor.authorChang, J
 
dc.contributor.authorLiu, Y
 
dc.contributor.authorSun, M
 
dc.contributor.authorCao, W
 
dc.contributor.authorGao, J
 
dc.contributor.authorMa, Y
 
dc.contributor.authorZheng, X
 
dc.contributor.authorCheung, ST
 
dc.contributor.authorJia, Y
 
dc.contributor.authorXu, J
 
dc.contributor.authorTan, W
 
dc.contributor.authorZhao, P
 
dc.contributor.authorWu, T
 
dc.contributor.authorWang, C
 
dc.contributor.authorLin, D
 
dc.date.accessioned2012-02-03T06:15:09Z
 
dc.date.available2012-02-03T06:15:09Z
 
dc.date.issued2012
 
dc.description.abstractPancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10 -13 to P = 4.18 × 10 -10) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.descriptionLetters
 
dc.identifier.citationNature Genetics, 2012, v. 44 n. 1, p. 62-66 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ng.1020
 
dc.identifier.citeulike10179024
 
dc.identifier.doihttp://dx.doi.org/10.1038/ng.1020
 
dc.identifier.epage66
 
dc.identifier.hkuros198366
 
dc.identifier.isiWOS:000298664000015
Funding AgencyGrant Number
National High-Tech Research and Development Program of China2009AA022706
National Natural Science Foundation of China81021061
Funding Information:

This work was supported by grants from the National High-Tech Research and Development Program of China (2009AA022706) and the National Natural Science Foundation of China (81021061) to D. L. We thank L. Liang for help in eQTL analysis. We also thank the subjects and the surgeons who recruited them; M. Yang, L. Wang, X. Wang, C. Yang, L. Du, J. Li, F. Qi, X. Song and L. Zeng.

 
dc.identifier.issn1061-4036
2012 Impact Factor: 35.209
2012 SCImago Journal Rankings: 20.421
 
dc.identifier.issue1
 
dc.identifier.pmid22158540
 
dc.identifier.scopuseid_2-s2.0-84655162046
 
dc.identifier.spage62
 
dc.identifier.urihttp://hdl.handle.net/10722/144597
 
dc.identifier.volume44
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNature Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAsian Continental Ancestry Group - genetics
 
dc.subject.meshGenetic Predisposition to Disease
 
dc.subject.meshGenome-Wide Association Study
 
dc.subject.meshPancreatic Neoplasms - genetics
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.titleGenome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations
 
dc.typeArticle
 
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Author Affiliations
  1. Affiliated Hospital
  2. China Medical University Shenyang
  3. The University of Hong Kong
  4. Fujian Medical University
  5. Nanjing Medical University
  6. Cancer Institute and Hospital, Chinese Academy of Medical Sciences
  7. Hunan Province Tumor Hospital
  8. Chinese Academy of Medical Sciences
  9. Huazhong University of Science and Technology
  10. Soochow University
  11. Fudan University
  12. Medical University
  13. Fujian Provincial Cancer Hospital
  14. Second Military Medical University
  15. Hebei Medical University