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Article: Impact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus

TitleImpact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus
Authors
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/
Citation
Cardiovascular Diabetology, 2011, v. 10 How to Cite?
AbstractBackground: Patients with type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction and arterial stiffness. Levels of circulating endothelial progenitor cells (EPCs) are also reduced in hyperglycemic states. However, the relationships between glycemic control, levels of EPCs and arterial stiffness are unknown.Methods: We measured circulating EPCs and brachial-ankle pulse wave velocity (baPWV) in 234 patients with type 2 DM and compared them with 121 age- and sex-matched controls.Results: Patients with DM had significantly lower circulating Log CD34/KDR + and Log CD133/KDR + EPC counts, and higher Log baPWV compared with controls (all P < 0.05). Among those 120/234 (51%) of DM patients with satisfactory glycemic control (defined by Hemoglobin A1c, HbA1c < 6.5%), they had significantly higher circulating Log CD34/KDR + and Log CD133/KDR + EPC counts, and lower Log baPWV compared with patients with poor glycemic control (all P < 0.05). The circulating levels of Log CD34/KDR + EPC (r = -0.46, P < 0.001) and Log CD133/KDR + EPC counts (r = -0.45, P < 0.001) were negatively correlated with Log baPWV. Whilst the level of HbA1c positively correlated with Log baPWV (r = 0.20, P < 0.05) and negatively correlated with circulating levels of Log CD34/KDR + EPC (r = -0.40, P < 0.001) and Log CD133/KDR + EPC (r = -0.41, P < 0.001). Multivariate analysis revealed that HbA1c, Log CD34/KDR + and Log CD133/KDR + EPC counts were independent predictors of Log baPWV (P < 0.05).Conclusions: In patients with type 2 DM, the level of circulating EPCs and arterial stiffness were closely related to their glycemic control. Furthermore, DM patients with satisfactory glycemic control had higher levels of circulating EPCs and were associated with lower arterial stiffness. © 2011 Yue et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/144559
ISSN
2015 Impact Factor: 4.534
2015 SCImago Journal Rankings: 1.757
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYue, WSen_HK
dc.contributor.authorLau, KKen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorYan, GHen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2012-02-03T06:13:42Z-
dc.date.available2012-02-03T06:13:42Z-
dc.date.issued2011en_HK
dc.identifier.citationCardiovascular Diabetology, 2011, v. 10en_HK
dc.identifier.issn1475-2840en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144559-
dc.description.abstractBackground: Patients with type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction and arterial stiffness. Levels of circulating endothelial progenitor cells (EPCs) are also reduced in hyperglycemic states. However, the relationships between glycemic control, levels of EPCs and arterial stiffness are unknown.Methods: We measured circulating EPCs and brachial-ankle pulse wave velocity (baPWV) in 234 patients with type 2 DM and compared them with 121 age- and sex-matched controls.Results: Patients with DM had significantly lower circulating Log CD34/KDR + and Log CD133/KDR + EPC counts, and higher Log baPWV compared with controls (all P < 0.05). Among those 120/234 (51%) of DM patients with satisfactory glycemic control (defined by Hemoglobin A1c, HbA1c < 6.5%), they had significantly higher circulating Log CD34/KDR + and Log CD133/KDR + EPC counts, and lower Log baPWV compared with patients with poor glycemic control (all P < 0.05). The circulating levels of Log CD34/KDR + EPC (r = -0.46, P < 0.001) and Log CD133/KDR + EPC counts (r = -0.45, P < 0.001) were negatively correlated with Log baPWV. Whilst the level of HbA1c positively correlated with Log baPWV (r = 0.20, P < 0.05) and negatively correlated with circulating levels of Log CD34/KDR + EPC (r = -0.40, P < 0.001) and Log CD133/KDR + EPC (r = -0.41, P < 0.001). Multivariate analysis revealed that HbA1c, Log CD34/KDR + and Log CD133/KDR + EPC counts were independent predictors of Log baPWV (P < 0.05).Conclusions: In patients with type 2 DM, the level of circulating EPCs and arterial stiffness were closely related to their glycemic control. Furthermore, DM patients with satisfactory glycemic control had higher levels of circulating EPCs and were associated with lower arterial stiffness. © 2011 Yue et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/en_HK
dc.relation.ispartofCardiovascular Diabetologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleImpact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, KK:gkklau@hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityLau, KK=rp01499en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1475-2840-10-113en_HK
dc.identifier.pmid22185563-
dc.identifier.scopuseid_2-s2.0-83655211818en_HK
dc.identifier.hkuros198413en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83655211818&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue1en_US
dc.identifier.eissn1475-2840-
dc.identifier.isiWOS:000299093200001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYue, WS=36106565300en_HK
dc.identifier.scopusauthoridLau, KK=22635159600en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridWang, M=54783758500en_HK
dc.identifier.scopusauthoridYan, GH=36544693600en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike10164259-

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