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Article: Bone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dog
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TitleBone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dog
 
AuthorsRossi, F1 3
Botticelli, D1 2
Pantani, F1
Pereira, FP1
Salata, LA5
Lang, NP4
 
Issue Date2012
 
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
 
CitationClinical Oral Implants Research, 2012, v. 23 n. 1, p. 41-48 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0501.2011.02170.x
 
AbstractOBJECTIVE: To describe the healing of marginal defects below or above 1 mm of dimension around submerged implants in a dog model. MATERIAL AND METHODS: In 12 Labrador dogs, all mandibular premolars and first molars were extracted bilaterally. After 3 months of healing, full-thickness flaps were elevated in the edentulous region of the right side of the mandible. Two recipient sites were prepared and the marginal 5 mm were widened to such an extent to obtain, after implant installation, a marginal gap of 0.5 mm at the mesial site (small defect) and of 1.25 mm at the distal site (large defect). Titanium healing caps were affixed to the implants and the flaps were sutured allowing a fully submerged healing. The experimental procedures were subsequently performed in the left side of the mandible. The timing of the experiments and sacrifices were planned in such a way to obtain biopsies representing the healing after 5, 10, 20 and 30 days. Ground sections were prepared and histomorphometrically analyzed. RESULTS: The filling of the defect with newly formed bone was incomplete after 1 month of healing in all specimens. Bone formation occurred from the base and the lateral walls of the defects. A larger volume of new bone was formed in the large compared with the small defects. Most of the new bone at the large defect was formed between the 10- and the 20-day period of healing. After 1 month of healing, the outline of the newly formed bone was, however, located at a similar distance from the implant surface (about 0.4 mm) at both defect types. Only minor newly formed bone in contact with the implant, starting from the base of the defects, was seen at the large defects (about 0.8 mm) while a larger amount was detected at the small defects (about 2.2 mm). CONCLUSION: Marginal defects around titanium implants appeared to regenerate in 20-30 days by means of a distance osteogenesis. The bone fill of the defects was, however, incomplete after 1 month.
 
ISSN0905-7161
2013 Impact Factor: 3.123
 
DOIhttp://dx.doi.org/10.1111/j.1600-0501.2011.02170.x
 
ISI Accession Number IDWOS:000298548900007
Funding AgencyGrant Number
Sweden & Martina SRL, Due Carrare, Padova, Italy
ARDEC, Ariminum Odontologica SRL, Rimini, Italy
Funding Information:

This study has been supported by a grant from Sweden & Martina SRL, Due Carrare, Padova, Italy and by ARDEC, Ariminum Odontologica SRL, Rimini, Italy. The competent contributions of Mr Sebastiao Bianco, Ribeirao Preto, Brazil in the histological processing are highly appreciated. All the authors declare no conflict of interest with the materials used in the present study.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorRossi, F
 
dc.contributor.authorBotticelli, D
 
dc.contributor.authorPantani, F
 
dc.contributor.authorPereira, FP
 
dc.contributor.authorSalata, LA
 
dc.contributor.authorLang, NP
 
dc.date.accessioned2012-02-03T06:11:24Z
 
dc.date.available2012-02-03T06:11:24Z
 
dc.date.issued2012
 
dc.description.abstractOBJECTIVE: To describe the healing of marginal defects below or above 1 mm of dimension around submerged implants in a dog model. MATERIAL AND METHODS: In 12 Labrador dogs, all mandibular premolars and first molars were extracted bilaterally. After 3 months of healing, full-thickness flaps were elevated in the edentulous region of the right side of the mandible. Two recipient sites were prepared and the marginal 5 mm were widened to such an extent to obtain, after implant installation, a marginal gap of 0.5 mm at the mesial site (small defect) and of 1.25 mm at the distal site (large defect). Titanium healing caps were affixed to the implants and the flaps were sutured allowing a fully submerged healing. The experimental procedures were subsequently performed in the left side of the mandible. The timing of the experiments and sacrifices were planned in such a way to obtain biopsies representing the healing after 5, 10, 20 and 30 days. Ground sections were prepared and histomorphometrically analyzed. RESULTS: The filling of the defect with newly formed bone was incomplete after 1 month of healing in all specimens. Bone formation occurred from the base and the lateral walls of the defects. A larger volume of new bone was formed in the large compared with the small defects. Most of the new bone at the large defect was formed between the 10- and the 20-day period of healing. After 1 month of healing, the outline of the newly formed bone was, however, located at a similar distance from the implant surface (about 0.4 mm) at both defect types. Only minor newly formed bone in contact with the implant, starting from the base of the defects, was seen at the large defects (about 0.8 mm) while a larger amount was detected at the small defects (about 2.2 mm). CONCLUSION: Marginal defects around titanium implants appeared to regenerate in 20-30 days by means of a distance osteogenesis. The bone fill of the defects was, however, incomplete after 1 month.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationClinical Oral Implants Research, 2012, v. 23 n. 1, p. 41-48 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0501.2011.02170.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1600-0501.2011.02170.x
 
dc.identifier.epage48
 
dc.identifier.hkuros198291
 
dc.identifier.isiWOS:000298548900007
Funding AgencyGrant Number
Sweden & Martina SRL, Due Carrare, Padova, Italy
ARDEC, Ariminum Odontologica SRL, Rimini, Italy
Funding Information:

This study has been supported by a grant from Sweden & Martina SRL, Due Carrare, Padova, Italy and by ARDEC, Ariminum Odontologica SRL, Rimini, Italy. The competent contributions of Mr Sebastiao Bianco, Ribeirao Preto, Brazil in the histological processing are highly appreciated. All the authors declare no conflict of interest with the materials used in the present study.

 
dc.identifier.issn0905-7161
2013 Impact Factor: 3.123
 
dc.identifier.issue1
 
dc.identifier.pmid21443594
 
dc.identifier.scopuseid_2-s2.0-84155172525
 
dc.identifier.spage41
 
dc.identifier.urihttp://hdl.handle.net/10722/144495
 
dc.identifier.volume23
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical Oral Implants Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.subject.meshAlveolar Process - physiology - surgery
 
dc.subject.meshDental Implantation, Endosseous - methods
 
dc.subject.meshDental Implants
 
dc.subject.meshMandible - physiology - surgery
 
dc.subject.meshOsteogenesis - physiology
 
dc.titleBone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dog
 
dc.typeArticle
 
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<contributor.author>Salata, LA</contributor.author>
<contributor.author>Lang, NP</contributor.author>
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<description.abstract>OBJECTIVE: To describe the healing of marginal defects below or above 1 mm of dimension around submerged implants in a dog model. MATERIAL AND METHODS: In 12 Labrador dogs, all mandibular premolars and first molars were extracted bilaterally. After 3 months of healing, full-thickness flaps were elevated in the edentulous region of the right side of the mandible. Two recipient sites were prepared and the marginal 5 mm were widened to such an extent to obtain, after implant installation, a marginal gap of 0.5 mm at the mesial site (small defect) and of 1.25 mm at the distal site (large defect). Titanium healing caps were affixed to the implants and the flaps were sutured allowing a fully submerged healing. The experimental procedures were subsequently performed in the left side of the mandible. The timing of the experiments and sacrifices were planned in such a way to obtain biopsies representing the healing after 5, 10, 20 and 30 days. Ground sections were prepared and histomorphometrically analyzed. RESULTS: The filling of the defect with newly formed bone was incomplete after 1 month of healing in all specimens. Bone formation occurred from the base and the lateral walls of the defects. A larger volume of new bone was formed in the large compared with the small defects. Most of the new bone at the large defect was formed between the 10- and the 20-day period of healing. After 1 month of healing, the outline of the newly formed bone was, however, located at a similar distance from the implant surface (about 0.4 mm) at both defect types. Only minor newly formed bone in contact with the implant, starting from the base of the defects, was seen at the large defects (about 0.8 mm) while a larger amount was detected at the small defects (about 2.2 mm). CONCLUSION: Marginal defects around titanium implants appeared to regenerate in 20-30 days by means of a distance osteogenesis. The bone fill of the defects was, however, incomplete after 1 month.</description.abstract>
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Author Affiliations
  1. UNESP-Universidade Estadual Paulista
  2. ARDEC
  3. Alma Mater Studiorum Università di Bologna
  4. Prince Philip Dental Hospital
  5. Universidade de Sao Paulo