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Article: Bone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dog

TitleBone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dog
Authors
Issue Date2012
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
Citation
Clinical Oral Implants Research, 2012, v. 23 n. 1, p. 41-48 How to Cite?
Abstract
OBJECTIVE: To describe the healing of marginal defects below or above 1 mm of dimension around submerged implants in a dog model. MATERIAL AND METHODS: In 12 Labrador dogs, all mandibular premolars and first molars were extracted bilaterally. After 3 months of healing, full-thickness flaps were elevated in the edentulous region of the right side of the mandible. Two recipient sites were prepared and the marginal 5 mm were widened to such an extent to obtain, after implant installation, a marginal gap of 0.5 mm at the mesial site (small defect) and of 1.25 mm at the distal site (large defect). Titanium healing caps were affixed to the implants and the flaps were sutured allowing a fully submerged healing. The experimental procedures were subsequently performed in the left side of the mandible. The timing of the experiments and sacrifices were planned in such a way to obtain biopsies representing the healing after 5, 10, 20 and 30 days. Ground sections were prepared and histomorphometrically analyzed. RESULTS: The filling of the defect with newly formed bone was incomplete after 1 month of healing in all specimens. Bone formation occurred from the base and the lateral walls of the defects. A larger volume of new bone was formed in the large compared with the small defects. Most of the new bone at the large defect was formed between the 10- and the 20-day period of healing. After 1 month of healing, the outline of the newly formed bone was, however, located at a similar distance from the implant surface (about 0.4 mm) at both defect types. Only minor newly formed bone in contact with the implant, starting from the base of the defects, was seen at the large defects (about 0.8 mm) while a larger amount was detected at the small defects (about 2.2 mm). CONCLUSION: Marginal defects around titanium implants appeared to regenerate in 20-30 days by means of a distance osteogenesis. The bone fill of the defects was, however, incomplete after 1 month.
Persistent Identifierhttp://hdl.handle.net/10722/144495
ISSN
2013 Impact Factor: 3.123
ISI Accession Number ID
Funding AgencyGrant Number
Sweden & Martina SRL, Due Carrare, Padova, Italy
ARDEC, Ariminum Odontologica SRL, Rimini, Italy
Funding Information:

This study has been supported by a grant from Sweden & Martina SRL, Due Carrare, Padova, Italy and by ARDEC, Ariminum Odontologica SRL, Rimini, Italy. The competent contributions of Mr Sebastiao Bianco, Ribeirao Preto, Brazil in the histological processing are highly appreciated. All the authors declare no conflict of interest with the materials used in the present study.

References

 

Author Affiliations
  1. UNESP-Universidade Estadual Paulista
  2. ARDEC
  3. Alma Mater Studiorum Università di Bologna
  4. Prince Philip Dental Hospital
  5. Universidade de Sao Paulo
DC FieldValueLanguage
dc.contributor.authorRossi, Fen_HK
dc.contributor.authorBotticelli, Den_HK
dc.contributor.authorPantani, Fen_HK
dc.contributor.authorPereira, FPen_HK
dc.contributor.authorSalata, LAen_HK
dc.contributor.authorLang, NPen_HK
dc.date.accessioned2012-02-03T06:11:24Z-
dc.date.available2012-02-03T06:11:24Z-
dc.date.issued2012en_HK
dc.identifier.citationClinical Oral Implants Research, 2012, v. 23 n. 1, p. 41-48en_HK
dc.identifier.issn0905-7161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144495-
dc.description.abstractOBJECTIVE: To describe the healing of marginal defects below or above 1 mm of dimension around submerged implants in a dog model. MATERIAL AND METHODS: In 12 Labrador dogs, all mandibular premolars and first molars were extracted bilaterally. After 3 months of healing, full-thickness flaps were elevated in the edentulous region of the right side of the mandible. Two recipient sites were prepared and the marginal 5 mm were widened to such an extent to obtain, after implant installation, a marginal gap of 0.5 mm at the mesial site (small defect) and of 1.25 mm at the distal site (large defect). Titanium healing caps were affixed to the implants and the flaps were sutured allowing a fully submerged healing. The experimental procedures were subsequently performed in the left side of the mandible. The timing of the experiments and sacrifices were planned in such a way to obtain biopsies representing the healing after 5, 10, 20 and 30 days. Ground sections were prepared and histomorphometrically analyzed. RESULTS: The filling of the defect with newly formed bone was incomplete after 1 month of healing in all specimens. Bone formation occurred from the base and the lateral walls of the defects. A larger volume of new bone was formed in the large compared with the small defects. Most of the new bone at the large defect was formed between the 10- and the 20-day period of healing. After 1 month of healing, the outline of the newly formed bone was, however, located at a similar distance from the implant surface (about 0.4 mm) at both defect types. Only minor newly formed bone in contact with the implant, starting from the base of the defects, was seen at the large defects (about 0.8 mm) while a larger amount was detected at the small defects (about 2.2 mm). CONCLUSION: Marginal defects around titanium implants appeared to regenerate in 20-30 days by means of a distance osteogenesis. The bone fill of the defects was, however, incomplete after 1 month.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLRen_HK
dc.relation.ispartofClinical Oral Implants Researchen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subject.meshAlveolar Process - physiology - surgery-
dc.subject.meshDental Implantation, Endosseous - methods-
dc.subject.meshDental Implants-
dc.subject.meshMandible - physiology - surgery-
dc.subject.meshOsteogenesis - physiology-
dc.titleBone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dogen_HK
dc.typeArticleen_HK
dc.identifier.emailBotticelli, D: daniele.botticelli@ardec.iten_HK
dc.identifier.emailLang, NP: nplang@hkucc.hku.hk-
dc.identifier.authorityLang, NP=rp00031en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0501.2011.02170.xen_HK
dc.identifier.pmid21443594-
dc.identifier.scopuseid_2-s2.0-84155172525en_HK
dc.identifier.hkuros198291en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84155172525&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue1en_HK
dc.identifier.spage41en_HK
dc.identifier.epage48en_HK
dc.identifier.isiWOS:000298548900007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLang, NP=7201577367en_HK
dc.identifier.scopusauthoridSalata, LA=6603503456en_HK
dc.identifier.scopusauthoridPereira, FP=37026934700en_HK
dc.identifier.scopusauthoridPantani, F=37008599600en_HK
dc.identifier.scopusauthoridBotticelli, D=6601962395en_HK
dc.identifier.scopusauthoridRossi, F=7401756510en_HK

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