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Article: Vasoconstrictor prostanoids

TitleVasoconstrictor prostanoids
Authors
KeywordsAging
Diabetes
EDCF
Endothelium-dependent contraction
Hypertension
TP receptors
Issue Date2010
PublisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00424/index.htm
Citation
Pflugers Archiv European Journal Of Physiology, 2010, v. 459 n. 6, p. 941-950 How to Cite?
AbstractIn cardiovascular diseases and during aging, endothelial dysfunction is due in part to the release of endothelium-derived contracting factors that counteract the vasodilator effect of the nitric oxide. Endotheliumdependent contractions involve the activation of endothelial cyclooxygenases and the release of various prostanoids, which activate thromboxane prostanoid (TP) receptors of the underlying vascular smooth muscle. The stimulation of TP receptors elicits not only the contraction and the proliferation of vascular smooth muscle cells but also diverse physiological/pathophysiological reactions, including platelet aggregation and activation of endothelial inflammatory responses. TP receptor antagonists curtail endothelial dysfunction in diseases such as hypertension and diabetes, are potent antithrombotic agents, and prevent vascular inflammation. © Springer-Verlag 2009.
Persistent Identifierhttp://hdl.handle.net/10722/144486
ISSN
2015 Impact Factor: 3.654
2015 SCImago Journal Rankings: 1.638
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFélétou, Men_HK
dc.contributor.authorHuang, Yen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.date.accessioned2012-01-31T06:31:27Z-
dc.date.available2012-01-31T06:31:27Z-
dc.date.issued2010en_HK
dc.identifier.citationPflugers Archiv European Journal Of Physiology, 2010, v. 459 n. 6, p. 941-950en_HK
dc.identifier.issn0031-6768en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144486-
dc.description.abstractIn cardiovascular diseases and during aging, endothelial dysfunction is due in part to the release of endothelium-derived contracting factors that counteract the vasodilator effect of the nitric oxide. Endotheliumdependent contractions involve the activation of endothelial cyclooxygenases and the release of various prostanoids, which activate thromboxane prostanoid (TP) receptors of the underlying vascular smooth muscle. The stimulation of TP receptors elicits not only the contraction and the proliferation of vascular smooth muscle cells but also diverse physiological/pathophysiological reactions, including platelet aggregation and activation of endothelial inflammatory responses. TP receptor antagonists curtail endothelial dysfunction in diseases such as hypertension and diabetes, are potent antithrombotic agents, and prevent vascular inflammation. © Springer-Verlag 2009.en_HK
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00424/index.htmen_HK
dc.relation.ispartofPflugers Archiv European Journal of Physiologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAgingen_HK
dc.subjectDiabetesen_HK
dc.subjectEDCFen_HK
dc.subjectEndothelium-dependent contractionen_HK
dc.subjectHypertensionen_HK
dc.subjectTP receptorsen_HK
dc.subject.meshAging - physiology-
dc.subject.meshArachidonic Acid - metabolism-
dc.subject.meshEndothelium, Vascular - physiology-
dc.subject.meshProstaglandins - pharmacology-
dc.subject.meshVasoconstrictor Agents - pharmacology-
dc.titleVasoconstrictor prostanoidsen_HK
dc.typeArticleen_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1007/s00424-010-0812-6en_HK
dc.identifier.pmid20333529-
dc.identifier.scopuseid_2-s2.0-77955284097en_HK
dc.identifier.hkuros170960-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955284097&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume459en_HK
dc.identifier.issue6en_HK
dc.identifier.spage941en_HK
dc.identifier.epage950en_HK
dc.identifier.isiWOS:000277376200014-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridFélétou, M=7006461826en_HK
dc.identifier.scopusauthoridHuang, Y=7501573013en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.citeulike6920772-

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