File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Development of allergic responses related to microorganisms exposure in early life

TitleDevelopment of allergic responses related to microorganisms exposure in early life
Authors
KeywordsAllergies
Antigens
Dermatitis
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/idairyj
Citation
International Dairy Journal, 2010, v. 20 n. 6, p. 373-385 How to Cite?
AbstractThe prevalence of allergic disorders may stem from reduced microbial exposure during childhood. Allergic disorders (rhinitis, asthma, atopic dermatitis) result from a systemic inflammatory reaction triggered by Th2-cell-mediated immune responses against 'innocuous' environmental antigens. Initial interpretations proposed an immune deviation of allergen-specific responses from a Th1 to a Th2 profile resulting from reduced production of interleukin-12 and interferons by natural immune cells stimulated by bacterial products. Both stereotypical and selective responses of innate host cells are invoked by different microorganisms. Early in an infection, pathogens can therefore imprint their 'signatures' on antigen-presenting cells and subsequent immune responses. This interaction between microorganisms and enterocytes is important for the controlled production of cytokines and chemokines. Some probiotic microorganisms can modulate the in vitro expression of pro- and anti-inflammatory cytokines in a strain-dependent manner, probably skew the immune response towards Th1 phenotype and play an important role in allergy prevention. Crown Copyright © 2010.
Persistent Identifierhttp://hdl.handle.net/10722/144460
ISSN
2015 Impact Factor: 1.938
2015 SCImago Journal Rankings: 0.991
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDonkor, ONen_HK
dc.contributor.authorShah, NPen_HK
dc.contributor.authorApostolopoulos, Ven_HK
dc.contributor.authorVasiljevic, Ten_HK
dc.date.accessioned2012-01-20T09:02:11Z-
dc.date.available2012-01-20T09:02:11Z-
dc.date.issued2010en_HK
dc.identifier.citationInternational Dairy Journal, 2010, v. 20 n. 6, p. 373-385en_HK
dc.identifier.issn0958-6946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144460-
dc.description.abstractThe prevalence of allergic disorders may stem from reduced microbial exposure during childhood. Allergic disorders (rhinitis, asthma, atopic dermatitis) result from a systemic inflammatory reaction triggered by Th2-cell-mediated immune responses against 'innocuous' environmental antigens. Initial interpretations proposed an immune deviation of allergen-specific responses from a Th1 to a Th2 profile resulting from reduced production of interleukin-12 and interferons by natural immune cells stimulated by bacterial products. Both stereotypical and selective responses of innate host cells are invoked by different microorganisms. Early in an infection, pathogens can therefore imprint their 'signatures' on antigen-presenting cells and subsequent immune responses. This interaction between microorganisms and enterocytes is important for the controlled production of cytokines and chemokines. Some probiotic microorganisms can modulate the in vitro expression of pro- and anti-inflammatory cytokines in a strain-dependent manner, probably skew the immune response towards Th1 phenotype and play an important role in allergy prevention. Crown Copyright © 2010.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/idairyjen_HK
dc.relation.ispartofInternational Dairy Journalen_HK
dc.subjectAllergiesen_US
dc.subjectAntigensen_US
dc.subjectDermatitisen_US
dc.titleDevelopment of allergic responses related to microorganisms exposure in early lifeen_HK
dc.typeArticleen_HK
dc.identifier.emailShah, NP: npshah@hku.hken_HK
dc.identifier.authorityShah, NP=rp01571en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.idairyj.2009.12.017en_HK
dc.identifier.scopuseid_2-s2.0-77950368536en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950368536&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue6en_HK
dc.identifier.spage373en_HK
dc.identifier.epage385en_HK
dc.identifier.isiWOS:000278166400001-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridDonkor, ON=8988839100en_HK
dc.identifier.scopusauthoridShah, NP=7401823907en_HK
dc.identifier.scopusauthoridApostolopoulos, V=7006680221en_HK
dc.identifier.scopusauthoridVasiljevic, T=8576782100en_HK
dc.identifier.citeulike6571338-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats