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Article: Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria

TitleBioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria
Authors
KeywordsBifidobacteria
Bioavailability
Isoflavone
Postmenopausal women
Soya milk
Issue Date2005
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=BJN
Citation
British Journal Of Nutrition, 2005, v. 93 n. 6, p. 867-877 How to Cite?
AbstractWe investigated the effects of consuming an isoflavone aglycone-enriched soya milk containing viable bifidobacteria on urinary isoflavone excretion and percentage recovery. Sixteen postmenopausal women were randomly divided into two groups to consume either fermented or non-fermented soya milk. Each group participated in a double-blind, crossover study with three 14d supplementation periods, separated by a 14 d washout. Subjects ingested three daily dosages of isoflavone via the soya milk and collected four 24 h pooled urine specimens per supplementation period. Soya milks were prepared with soya protein isolate and soya germ, followed by fermentation with bifidobacteria. Isoflavone levels were quantified using HPLC. Non-fermented soya milks at 20, 40 and 80 mg isoflavone/200ml contained 10%, 9% and 7% aglycone, respectively, with their fermented counterparts containing 69%, 57% and 36 % aglycone (P<0.001). A trend to a greater percentage urinary recovery of daidzein and glycitein was observed among women consuming fermented soya milk at a dosage of 40 mg isoflavone (P=0.13). A distinct linear dose response for the fermented soya milk group (R2=0.9993) compared with the non-fermented group (R 2 = 0.8865) suggested less interindividual variation in isoflavone absorption. However, total urinary isoflavone excretion was similar for both groups (P>0.05), with urinary isoflavone recovery at approximately 31%. Increasing the isoflavone dosage correlated positively with its urinary excretion, but urinary percentage recovery of isoflavone was inversely related to dosage level. Hence, a modest dosage ranging from 20 to 30 mg/d may provide the most bioavailable source of isoflavone, regardless of whether it is via an aglycone-rich fermented soya milk or a glucoside-rich soya milk. © The Authors 2005.
Persistent Identifierhttp://hdl.handle.net/10722/144442
ISSN
2015 Impact Factor: 3.311
2015 SCImago Journal Rankings: 1.587
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsangalis, Den_HK
dc.contributor.authorWilcox, Gen_HK
dc.contributor.authorShah, NPen_HK
dc.contributor.authorStojanovska, Len_HK
dc.date.accessioned2012-01-20T09:02:06Z-
dc.date.available2012-01-20T09:02:06Z-
dc.date.issued2005en_HK
dc.identifier.citationBritish Journal Of Nutrition, 2005, v. 93 n. 6, p. 867-877en_HK
dc.identifier.issn0007-1145en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144442-
dc.description.abstractWe investigated the effects of consuming an isoflavone aglycone-enriched soya milk containing viable bifidobacteria on urinary isoflavone excretion and percentage recovery. Sixteen postmenopausal women were randomly divided into two groups to consume either fermented or non-fermented soya milk. Each group participated in a double-blind, crossover study with three 14d supplementation periods, separated by a 14 d washout. Subjects ingested three daily dosages of isoflavone via the soya milk and collected four 24 h pooled urine specimens per supplementation period. Soya milks were prepared with soya protein isolate and soya germ, followed by fermentation with bifidobacteria. Isoflavone levels were quantified using HPLC. Non-fermented soya milks at 20, 40 and 80 mg isoflavone/200ml contained 10%, 9% and 7% aglycone, respectively, with their fermented counterparts containing 69%, 57% and 36 % aglycone (P<0.001). A trend to a greater percentage urinary recovery of daidzein and glycitein was observed among women consuming fermented soya milk at a dosage of 40 mg isoflavone (P=0.13). A distinct linear dose response for the fermented soya milk group (R2=0.9993) compared with the non-fermented group (R 2 = 0.8865) suggested less interindividual variation in isoflavone absorption. However, total urinary isoflavone excretion was similar for both groups (P>0.05), with urinary isoflavone recovery at approximately 31%. Increasing the isoflavone dosage correlated positively with its urinary excretion, but urinary percentage recovery of isoflavone was inversely related to dosage level. Hence, a modest dosage ranging from 20 to 30 mg/d may provide the most bioavailable source of isoflavone, regardless of whether it is via an aglycone-rich fermented soya milk or a glucoside-rich soya milk. © The Authors 2005.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=BJNen_HK
dc.relation.ispartofBritish Journal of Nutritionen_HK
dc.subjectBifidobacteriaen_HK
dc.subjectBioavailabilityen_HK
dc.subjectIsoflavoneen_HK
dc.subjectPostmenopausal womenen_HK
dc.subjectSoya milken_HK
dc.titleBioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteriaen_HK
dc.typeArticleen_HK
dc.identifier.emailShah, NP: npshah@hku.hken_HK
dc.identifier.authorityShah, NP=rp01571en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1079/BJN20041299en_HK
dc.identifier.pmid16022756-
dc.identifier.scopuseid_2-s2.0-24044475615en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24044475615&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume93en_HK
dc.identifier.issue6en_HK
dc.identifier.spage867en_HK
dc.identifier.epage877en_HK
dc.identifier.eissn1475-2662-
dc.identifier.isiWOS:000230513800015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTsangalis, D=6508214893en_HK
dc.identifier.scopusauthoridWilcox, G=7102388291en_HK
dc.identifier.scopusauthoridShah, NP=7401823907en_HK
dc.identifier.scopusauthoridStojanovska, L=6602210033en_HK
dc.identifier.citeulike257210-

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