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Article: Effects of a synbiotic containing Lactobacillus acidophilus ATCC 4962 on plasma lipid profiles and morphology of erythrocytes in hypercholesterolaemic pigs on high- and low-fat diets

TitleEffects of a synbiotic containing Lactobacillus acidophilus ATCC 4962 on plasma lipid profiles and morphology of erythrocytes in hypercholesterolaemic pigs on high- and low-fat diets
Authors
KeywordsCholesterol
Fructooligosaccharide
Inulin
Lactobacillus
Mannitol
Issue Date2007
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=BJN
Citation
British Journal Of Nutrition, 2007, v. 98 n. 4, p. 736-744 How to Cite?
AbstractThe aim of this study was to evaluate the effect of a synbiotic containing Lactobacillus acidophilus ATCC 4962, fructooligosaccharide, inulin and mannitol on plasma lipid profiles and erythrocyte membrane properties in hypercholesterolaemic pigs on high- and low-fat diets. Twenty-four white male Landrace pigs were randomly allocated to four treatment groups for 8 weeks (n 6). Treatment factors were the supplementation of synbiotic (with and without) and dietary fat (5 and 15 %). The supplementation of synbiotic reduced plasma total cholesterol (P=0.001), TAG (P=0.002) and LDL-cholesterol (P=0.045) for both dietary fats. A higher concentration of esterified-cholesterol in HDL of pigs supplemented with synbiotic than the control regardless of dietary fat (P=0.036) indicated that cholesterol was reduced in the form of cholesteryl esters. Reduced concentration of cholesteryl esters (P<0.001) and increased concentration of TAG (P=0.042) in LDL of pigs on synbiotic suggested that LDL-cholesterol was reduced via the hydrolysis of smaller and denser LDL particles. The erythrocytes of pigs without any synbiotic showed more prevalence of spur cells than those given the synbiotic, as supported by the higher cholesterol: phospholipid ratio in erythrocytes (P=0.001). Also, membrane fluidity and rigidity were improved as supported by the decreased fluorescence anisotropies in the Hb-free erythrocyte membrane of pigs given synbiotic (P<0.001). The administration of the synbiotic reduced plasma TAG, total cholesterol and LDL-cholesterol in hypercholesterolaemic pigs, possibly in the form of cholesteryl esters, via the interrelated pathways of lipid transporters (VLDL, LDL and HDL). The synbiotic also reduced deformation of erythrocytes via improved membrane fluidity and permeability. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/144409
ISSN
2015 Impact Factor: 3.311
2015 SCImago Journal Rankings: 1.587
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiong, MTen_HK
dc.contributor.authorDunshea, FRen_HK
dc.contributor.authorShah, NPen_HK
dc.date.accessioned2012-01-20T09:01:53Z-
dc.date.available2012-01-20T09:01:53Z-
dc.date.issued2007en_HK
dc.identifier.citationBritish Journal Of Nutrition, 2007, v. 98 n. 4, p. 736-744en_HK
dc.identifier.issn0007-1145en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144409-
dc.description.abstractThe aim of this study was to evaluate the effect of a synbiotic containing Lactobacillus acidophilus ATCC 4962, fructooligosaccharide, inulin and mannitol on plasma lipid profiles and erythrocyte membrane properties in hypercholesterolaemic pigs on high- and low-fat diets. Twenty-four white male Landrace pigs were randomly allocated to four treatment groups for 8 weeks (n 6). Treatment factors were the supplementation of synbiotic (with and without) and dietary fat (5 and 15 %). The supplementation of synbiotic reduced plasma total cholesterol (P=0.001), TAG (P=0.002) and LDL-cholesterol (P=0.045) for both dietary fats. A higher concentration of esterified-cholesterol in HDL of pigs supplemented with synbiotic than the control regardless of dietary fat (P=0.036) indicated that cholesterol was reduced in the form of cholesteryl esters. Reduced concentration of cholesteryl esters (P<0.001) and increased concentration of TAG (P=0.042) in LDL of pigs on synbiotic suggested that LDL-cholesterol was reduced via the hydrolysis of smaller and denser LDL particles. The erythrocytes of pigs without any synbiotic showed more prevalence of spur cells than those given the synbiotic, as supported by the higher cholesterol: phospholipid ratio in erythrocytes (P=0.001). Also, membrane fluidity and rigidity were improved as supported by the decreased fluorescence anisotropies in the Hb-free erythrocyte membrane of pigs given synbiotic (P<0.001). The administration of the synbiotic reduced plasma TAG, total cholesterol and LDL-cholesterol in hypercholesterolaemic pigs, possibly in the form of cholesteryl esters, via the interrelated pathways of lipid transporters (VLDL, LDL and HDL). The synbiotic also reduced deformation of erythrocytes via improved membrane fluidity and permeability. © 2007 The Authors.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=BJNen_HK
dc.relation.ispartofBritish Journal of Nutritionen_HK
dc.subjectCholesterolen_HK
dc.subjectFructooligosaccharideen_HK
dc.subjectInulinen_HK
dc.subjectLactobacillusen_HK
dc.subjectMannitolen_HK
dc.titleEffects of a synbiotic containing Lactobacillus acidophilus ATCC 4962 on plasma lipid profiles and morphology of erythrocytes in hypercholesterolaemic pigs on high- and low-fat dietsen_HK
dc.typeArticleen_HK
dc.identifier.emailShah, NP: npshah@hku.hken_HK
dc.identifier.authorityShah, NP=rp01571en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0007114507747803en_HK
dc.identifier.pmid17490507-
dc.identifier.scopuseid_2-s2.0-34748922305en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34748922305&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume98en_HK
dc.identifier.issue4en_HK
dc.identifier.spage736en_HK
dc.identifier.epage744en_HK
dc.identifier.eissn1475-2662-
dc.identifier.isiWOS:000250903200011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiong, MT=22035883200en_HK
dc.identifier.scopusauthoridDunshea, FR=7005947650en_HK
dc.identifier.scopusauthoridShah, NP=7401823907en_HK

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