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Article: Antimutagenic properties of probiotic bacteria and of organic acids

TitleAntimutagenic properties of probiotic bacteria and of organic acids
Authors
KeywordsAntimutagenicity
Bifidobacteria
Butyric acid
Lactobacillus acidophilus
Mutagen
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/mut
Citation
Mutation Research - Fundamental And Molecular Mechanisms Of Mutagenesis, 1998, v. 397 n. 2, p. 169-182 How to Cite?
AbstractAntimutagenic activities of live and killed cells of 6 strains of Lactobacillus acidophilus and 9 strains of bifidobacteria and of organic acids usually produced by these probiotic bacteria were determined using 8 potent chemical mutagens and promutagens. The mutagens and promutagens used were N-methyl, N'-nitro, N-nitrosoguanidine; 2-nitroflourene; 4-nitro-O- phenylenediamine; 4-nitroquinoline-N-oxide; Aflatoxin-B; 2-amino-3-methyl- 3H-imidazoquinoline; 2-amino-1-methyl-6-phenyl-imidazo (4,5-b) pyridine, and 2-amino-3-methyl-9H-pyrido (3,3-6) indole. The mutagenicity of these mutagens and antimutagenic activity of probiotic bacteria against the mutagens were determined according to the Ames TA-100 assay using a mutant Salmonella typhimurium. Efficiency of bacterial cells in binding or inhibiting these mutagens was also investigated. Live cells of probiotic bacteria showed higher antimutagenic activity and their efficiency in inhibiting the mutagens was better than killed bacterial cells. Live bacterial cells bound or inhibited the mutagens permanently, whereas killed bacteria released mutagens upon extraction with dimethyl sulfoxide. Among the organic acids, butyric acid showed highest inhibition of mutagens followed by acetic acid. Lactic and pyruvic acids did not show appreciable levels of inhibition.
Persistent Identifierhttp://hdl.handle.net/10722/144359
ISSN
2015 Impact Factor: 2.581
2015 SCImago Journal Rankings: 0.703
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLankaputhra, WEVen_HK
dc.contributor.authorShah, NPen_HK
dc.date.accessioned2012-01-20T09:01:37Z-
dc.date.available2012-01-20T09:01:37Z-
dc.date.issued1998en_HK
dc.identifier.citationMutation Research - Fundamental And Molecular Mechanisms Of Mutagenesis, 1998, v. 397 n. 2, p. 169-182en_HK
dc.identifier.issn0027-5107en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144359-
dc.description.abstractAntimutagenic activities of live and killed cells of 6 strains of Lactobacillus acidophilus and 9 strains of bifidobacteria and of organic acids usually produced by these probiotic bacteria were determined using 8 potent chemical mutagens and promutagens. The mutagens and promutagens used were N-methyl, N'-nitro, N-nitrosoguanidine; 2-nitroflourene; 4-nitro-O- phenylenediamine; 4-nitroquinoline-N-oxide; Aflatoxin-B; 2-amino-3-methyl- 3H-imidazoquinoline; 2-amino-1-methyl-6-phenyl-imidazo (4,5-b) pyridine, and 2-amino-3-methyl-9H-pyrido (3,3-6) indole. The mutagenicity of these mutagens and antimutagenic activity of probiotic bacteria against the mutagens were determined according to the Ames TA-100 assay using a mutant Salmonella typhimurium. Efficiency of bacterial cells in binding or inhibiting these mutagens was also investigated. Live cells of probiotic bacteria showed higher antimutagenic activity and their efficiency in inhibiting the mutagens was better than killed bacterial cells. Live bacterial cells bound or inhibited the mutagens permanently, whereas killed bacteria released mutagens upon extraction with dimethyl sulfoxide. Among the organic acids, butyric acid showed highest inhibition of mutagens followed by acetic acid. Lactic and pyruvic acids did not show appreciable levels of inhibition.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/muten_HK
dc.relation.ispartofMutation Research - Fundamental and Molecular Mechanisms of Mutagenesisen_HK
dc.subjectAntimutagenicityen_HK
dc.subjectBifidobacteriaen_HK
dc.subjectButyric aciden_HK
dc.subjectLactobacillus acidophilusen_HK
dc.subjectMutagenen_HK
dc.titleAntimutagenic properties of probiotic bacteria and of organic acidsen_HK
dc.typeArticleen_HK
dc.identifier.emailShah, NP: npshah@hku.hken_HK
dc.identifier.authorityShah, NP=rp01571en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0027-5107(97)00208-Xen_HK
dc.identifier.pmid9541641-
dc.identifier.scopuseid_2-s2.0-0032472942en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032472942&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume397en_HK
dc.identifier.issue2en_HK
dc.identifier.spage169en_HK
dc.identifier.epage182en_HK
dc.identifier.isiWOS:000072643200005-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLankaputhra, WEV=6603120845en_HK
dc.identifier.scopusauthoridShah, NP=7401823907en_HK

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