File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cerebral grey, white matter and csf in never-medicated, first-episode schizophrenia

TitleCerebral grey, white matter and csf in never-medicated, first-episode schizophrenia
Authors
KeywordsMRI
Psychosis
Schizophrenia
Voxel-based morphometry
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2007, v. 89 n. 1-3, p. 12-21 How to Cite?
AbstractWe report the first voxel-based morphometric (VBM) study to examine cerebral grey and white matter and cerebrospinal fluid (CSF) using computational morphometry in never-medicated, first-episode psychosis (FEP). Region-of-interest (ROI) analysis was also performed blind to group membership. 26 never-medicated individuals with FEP (23 with DSM-IV schizophrenia) and 38 healthy controls had MRI brain scans. Groups were balanced for age, sex, handedness, ethnicity, paternal socio-economic status, and height. Healthy controls were recruited from the local community by advertisement. Grey matter, white matter, and CSF: global brain volume ratios were significantly smaller in patients. Patients had significantly less grey matter volume in L and R caudate nuclei, cingulate gyri, parahippocampal gyri, superior temporal gyri, cerebellum and R thalamus, prefrontal cortex. They also had significantly less white matter volume in the R anterior limb of the internal capsule fronto-occipital fasciculus and L and R fornices, and significantly greater CSF volume especially in the R lateral ventricle. Excluding the 3 subjects with brief psychotic disorder did not alter our results. Our data suggest that fronto-temporal and subcortical-limbic circuits are morphologically abnormal in never-medicated, schizophrenia. ROI analysis comparing the schizophrenia group (n = 23) with the healthy controls (n = 38) confirmed caudate volumes were significantly smaller bilaterally by 11%, and lateral ventricular volume was significantly larger on the right by 26% in the patients. Caudate nuclei and lateral ventricular volume measurements were uncorrelated (Pearson correlation coefficient 0.30, p = 0.10), ruling out the possibility of segmentation artefact. Ratio of lateral ventricle to caudate volume was bilaterally significantly increased (p < 0.005, 2-tailed), which could represent an early biomarker in first-episode, never-medicated schizophrenia. © 2006 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/144325
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChua, SEen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorTsang, JTKen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorWong, JCHen_HK
dc.contributor.authorCheung, JPYen_HK
dc.contributor.authorYip, Len_HK
dc.contributor.authorTai, Ksen_HK
dc.contributor.authorSuckling, Jen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.date.accessioned2012-01-20T09:01:03Z-
dc.date.available2012-01-20T09:01:03Z-
dc.date.issued2007en_HK
dc.identifier.citationSchizophrenia Research, 2007, v. 89 n. 1-3, p. 12-21en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144325-
dc.description.abstractWe report the first voxel-based morphometric (VBM) study to examine cerebral grey and white matter and cerebrospinal fluid (CSF) using computational morphometry in never-medicated, first-episode psychosis (FEP). Region-of-interest (ROI) analysis was also performed blind to group membership. 26 never-medicated individuals with FEP (23 with DSM-IV schizophrenia) and 38 healthy controls had MRI brain scans. Groups were balanced for age, sex, handedness, ethnicity, paternal socio-economic status, and height. Healthy controls were recruited from the local community by advertisement. Grey matter, white matter, and CSF: global brain volume ratios were significantly smaller in patients. Patients had significantly less grey matter volume in L and R caudate nuclei, cingulate gyri, parahippocampal gyri, superior temporal gyri, cerebellum and R thalamus, prefrontal cortex. They also had significantly less white matter volume in the R anterior limb of the internal capsule fronto-occipital fasciculus and L and R fornices, and significantly greater CSF volume especially in the R lateral ventricle. Excluding the 3 subjects with brief psychotic disorder did not alter our results. Our data suggest that fronto-temporal and subcortical-limbic circuits are morphologically abnormal in never-medicated, schizophrenia. ROI analysis comparing the schizophrenia group (n = 23) with the healthy controls (n = 38) confirmed caudate volumes were significantly smaller bilaterally by 11%, and lateral ventricular volume was significantly larger on the right by 26% in the patients. Caudate nuclei and lateral ventricular volume measurements were uncorrelated (Pearson correlation coefficient 0.30, p = 0.10), ruling out the possibility of segmentation artefact. Ratio of lateral ventricle to caudate volume was bilaterally significantly increased (p < 0.005, 2-tailed), which could represent an early biomarker in first-episode, never-medicated schizophrenia. © 2006 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectMRIen_HK
dc.subjectPsychosisen_HK
dc.subjectSchizophreniaen_HK
dc.subjectVoxel-based morphometryen_HK
dc.titleCerebral grey, white matter and csf in never-medicated, first-episode schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailCheung, JPY: cheungjp@hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authorityCheung, JPY=rp01685en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.schres.2006.09.009en_HK
dc.identifier.pmid17098398-
dc.identifier.scopuseid_2-s2.0-33845442864en_HK
dc.identifier.hkuros123697-
dc.identifier.hkuros212388-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845442864&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage12en_HK
dc.identifier.epage21en_HK
dc.identifier.isiWOS:000243655600002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridCheung, V=7005439024en_HK
dc.identifier.scopusauthoridTsang, JTK=15137565900en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridWong, JCH=14036517700en_HK
dc.identifier.scopusauthoridCheung, JPY=24554121300en_HK
dc.identifier.scopusauthoridYip, L=7006233502en_HK
dc.identifier.scopusauthoridTai, Ks=7101738949en_HK
dc.identifier.scopusauthoridSuckling, J=7004124496en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats