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Article: Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome.

TitleDistinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome.
Authors
Issue Date2008
Citation
Journal Of Child Psychology And Psychiatry, And Allied Disciplines, 2008, v. 49 n. 12, p. 1287-1295 How to Cite?
AbstractBACKGROUND: Autism exists across a wide spectrum and there is considerable debate as to whether children with Asperger's syndrome, who have normal language milestones, should be considered to comprise a subgroup distinct other from high-functioning children with autism (HFA), who have a history of delayed language development. Magnetic resonance imaging (MRI) studies of autism are in disagreement. One possible reason is that the diagnosis of autism takes precedence over Asperger's syndrome and a distinction in language acquisition is rarely made. We therefore planned to examine a whole brain hypothesis that the patterns of grey matter differences in Asperger's syndrome and HFA can be distinguished. METHODS: We used voxel-based computational morphometry to map grey matter volume differences in 33 children with either Asperger's syndrome or high-functioning autism compared to 55 typical developing control children balanced for age, IQ, gender, maternal language and ethnicity. RESULTS: Children with HFA had significantly smaller grey matter volumes in subcortical, posterior cingulate and precuneus regions than the Asperger's group. Compared to controls, children with HFA had smaller grey matter volumes in predominantly fronto-pallidal regions, while children with Asperger's had less grey matter in mainly bilateral caudate and left thalamus. In addition we found a significant negative correlation between the size of a grey matter cluster around BA44 language area and the age of acquisition of phrase speech in the children with HFA. When the groups were combined we confirmed a mixed picture of smaller grey matter volumes in frontal, basal ganglia, temporal and parietal regions. CONCLUSIONS: Our study suggests that the underlying neurobiology in HFA and Asperger's syndrome is at least partly discrete. Future studies should therefore consider the history of language acquisition as a valuable tool to refine investigation of aetiological factors and management options in pervasive developmental disorders.
Persistent Identifierhttp://hdl.handle.net/10722/144320
ISSN
2015 SCImago Journal Rankings: 3.046
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorSuckling, Jen_HK
dc.contributor.authorWong, Nen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorLienenkaemper, Nen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorChua, SEen_HK
dc.date.accessioned2012-01-20T09:00:53Z-
dc.date.available2012-01-20T09:00:53Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Child Psychology And Psychiatry, And Allied Disciplines, 2008, v. 49 n. 12, p. 1287-1295en_HK
dc.identifier.issn1469-7610en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144320-
dc.description.abstractBACKGROUND: Autism exists across a wide spectrum and there is considerable debate as to whether children with Asperger's syndrome, who have normal language milestones, should be considered to comprise a subgroup distinct other from high-functioning children with autism (HFA), who have a history of delayed language development. Magnetic resonance imaging (MRI) studies of autism are in disagreement. One possible reason is that the diagnosis of autism takes precedence over Asperger's syndrome and a distinction in language acquisition is rarely made. We therefore planned to examine a whole brain hypothesis that the patterns of grey matter differences in Asperger's syndrome and HFA can be distinguished. METHODS: We used voxel-based computational morphometry to map grey matter volume differences in 33 children with either Asperger's syndrome or high-functioning autism compared to 55 typical developing control children balanced for age, IQ, gender, maternal language and ethnicity. RESULTS: Children with HFA had significantly smaller grey matter volumes in subcortical, posterior cingulate and precuneus regions than the Asperger's group. Compared to controls, children with HFA had smaller grey matter volumes in predominantly fronto-pallidal regions, while children with Asperger's had less grey matter in mainly bilateral caudate and left thalamus. In addition we found a significant negative correlation between the size of a grey matter cluster around BA44 language area and the age of acquisition of phrase speech in the children with HFA. When the groups were combined we confirmed a mixed picture of smaller grey matter volumes in frontal, basal ganglia, temporal and parietal regions. CONCLUSIONS: Our study suggests that the underlying neurobiology in HFA and Asperger's syndrome is at least partly discrete. Future studies should therefore consider the history of language acquisition as a valuable tool to refine investigation of aetiological factors and management options in pervasive developmental disorders.en_HK
dc.languageengen_US
dc.relation.ispartofJournal of child psychology and psychiatry, and allied disciplinesen_HK
dc.titleDistinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome.en_HK
dc.typeArticleen_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1469-7610.2008.01933.xen_HK
dc.identifier.pmid18673405-
dc.identifier.scopuseid_2-s2.0-64349089737en_HK
dc.identifier.hkuros148806-
dc.identifier.volume49en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1287en_HK
dc.identifier.epage1295en_HK
dc.identifier.isiWOS:000261114500006-
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridSuckling, J=7004124496en_HK
dc.identifier.scopusauthoridWong, N=26432840200en_HK
dc.identifier.scopusauthoridCheung, V=7005439024en_HK
dc.identifier.scopusauthoridLienenkaemper, N=26432751700en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.citeulike3682692-

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