File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Age-related grey matter volume correlates of response inhibition and shifting in attention- Deficit hyperactivity disorder

TitleAge-related grey matter volume correlates of response inhibition and shifting in attention- Deficit hyperactivity disorder
Authors
Issue Date2009
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 2009, v. 194 n. 2, p. 123-129 How to Cite?
AbstractBackground Children with attention-deficit hyperactivity disorder (ADHD) have difficulties with executive function and impulse control which may improve with age. Aims To map the brain correlates of executive function in ADHD and determine age-related changes in reaction times and brain volumes. Method Attention-deficit hyperactivity disorder and control groups were compared on the change task measures of response inhibition (stop signal reaction time, SSRT) and shifting (change response reaction time, CRRT). voxel-wise magnetic resonance imaging (MRI) correlations of reaction times and grey matter volume were determined, along with bivariate correlations of reaction times, brain volumes and age.Results Individuals in the ADHD group had longer SSRTs and CRRTs. Anterior cingulate, striatal and medial temporal volumes highly correlated with SSRT. Striatal and cerebellar volumes strongly correlated with CRRT. Older children had faster reaction times and larger regional brain volumes. In controls, orbitofrontal, medial temporal and cerebellar volumes correlated with CRRT but not SSRT. Neither reaction times nor regional brain volumes were strongly age- dependent. Conclusions Our evidence supports delayed brain maturation in ADHD and implies that some features of ADHD improve with age.
Persistent Identifierhttp://hdl.handle.net/10722/144319
ISSN
2023 Impact Factor: 8.7
2023 SCImago Journal Rankings: 2.717
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

study was supported by a University of Hong Kong Grant to S.E.C. The authors would like to thank Ms Michelle Deng for her help with figure preparation.

References

 

DC FieldValueLanguage
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorChua, SEen_HK
dc.contributor.authorOosterlaan, Jen_HK
dc.contributor.authorHung, SFen_HK
dc.contributor.authorTang, CPen_HK
dc.contributor.authorLee, CCen_HK
dc.contributor.authorKwong, SLen_HK
dc.contributor.authorHo, TPen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorSuckling, Jen_HK
dc.contributor.authorLeung, PWLen_HK
dc.date.accessioned2012-01-20T09:00:52Z-
dc.date.available2012-01-20T09:00:52Z-
dc.date.issued2009en_HK
dc.identifier.citationBritish Journal Of Psychiatry, 2009, v. 194 n. 2, p. 123-129en_HK
dc.identifier.issn0007-1250en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144319-
dc.description.abstractBackground Children with attention-deficit hyperactivity disorder (ADHD) have difficulties with executive function and impulse control which may improve with age. Aims To map the brain correlates of executive function in ADHD and determine age-related changes in reaction times and brain volumes. Method Attention-deficit hyperactivity disorder and control groups were compared on the change task measures of response inhibition (stop signal reaction time, SSRT) and shifting (change response reaction time, CRRT). voxel-wise magnetic resonance imaging (MRI) correlations of reaction times and grey matter volume were determined, along with bivariate correlations of reaction times, brain volumes and age.Results Individuals in the ADHD group had longer SSRTs and CRRTs. Anterior cingulate, striatal and medial temporal volumes highly correlated with SSRT. Striatal and cerebellar volumes strongly correlated with CRRT. Older children had faster reaction times and larger regional brain volumes. In controls, orbitofrontal, medial temporal and cerebellar volumes correlated with CRRT but not SSRT. Neither reaction times nor regional brain volumes were strongly age- dependent. Conclusions Our evidence supports delayed brain maturation in ADHD and implies that some features of ADHD improve with age.en_HK
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_HK
dc.relation.ispartofBritish Journal of Psychiatryen_HK
dc.titleAge-related grey matter volume correlates of response inhibition and shifting in attention- Deficit hyperactivity disorderen_HK
dc.typeArticleen_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.bp.108.051359en_HK
dc.identifier.pmid19182173-
dc.identifier.scopuseid_2-s2.0-60149090875en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60149090875&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume194en_HK
dc.identifier.issue2en_HK
dc.identifier.spage123en_HK
dc.identifier.epage129en_HK
dc.identifier.eissn1472-1465-
dc.identifier.isiWOS:000263338300006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridCheung, V=7005439024en_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridOosterlaan, J=6602192389en_HK
dc.identifier.scopusauthoridHung, SF=7201936267en_HK
dc.identifier.scopusauthoridTang, CP=7404394434en_HK
dc.identifier.scopusauthoridLee, CC=9838999600en_HK
dc.identifier.scopusauthoridKwong, SL=9842134300en_HK
dc.identifier.scopusauthoridHo, TP=7402460680en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridSuckling, J=7004124496en_HK
dc.identifier.scopusauthoridLeung, PWL=7401748962en_HK
dc.identifier.issnl0007-1250-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats