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Article: Age-related grey matter volume correlates of response inhibition and shifting in attention- Deficit hyperactivity disorder
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TitleAge-related grey matter volume correlates of response inhibition and shifting in attention- Deficit hyperactivity disorder
 
AuthorsMcAlonan, GM1
Cheung, V
Chua, SE3
Oosterlaan, J5
Hung, SF
Tang, CP
Lee, CC
Kwong, SL2
Ho, TP
Cheung, C
Suckling, J4
Leung, PWL6
 
Issue Date2009
 
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
 
CitationBritish Journal Of Psychiatry, 2009, v. 194 n. 2, p. 123-129 [How to Cite?]
DOI: http://dx.doi.org/10.1192/bjp.bp.108.051359
 
AbstractBackground Children with attention-deficit hyperactivity disorder (ADHD) have difficulties with executive function and impulse control which may improve with age. Aims To map the brain correlates of executive function in ADHD and determine age-related changes in reaction times and brain volumes. Method Attention-deficit hyperactivity disorder and control groups were compared on the change task measures of response inhibition (stop signal reaction time, SSRT) and shifting (change response reaction time, CRRT). voxel-wise magnetic resonance imaging (MRI) correlations of reaction times and grey matter volume were determined, along with bivariate correlations of reaction times, brain volumes and age.Results Individuals in the ADHD group had longer SSRTs and CRRTs. Anterior cingulate, striatal and medial temporal volumes highly correlated with SSRT. Striatal and cerebellar volumes strongly correlated with CRRT. Older children had faster reaction times and larger regional brain volumes. In controls, orbitofrontal, medial temporal and cerebellar volumes correlated with CRRT but not SSRT. Neither reaction times nor regional brain volumes were strongly age- dependent. Conclusions Our evidence supports delayed brain maturation in ADHD and implies that some features of ADHD improve with age.
 
ISSN0007-1250
2012 Impact Factor: 6.606
2012 SCImago Journal Rankings: 2.524
 
DOIhttp://dx.doi.org/10.1192/bjp.bp.108.051359
 
ISI Accession Number IDWOS:000263338300006
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

study was supported by a University of Hong Kong Grant to S.E.C. The authors would like to thank Ms Michelle Deng for her help with figure preparation.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMcAlonan, GM
 
dc.contributor.authorCheung, V
 
dc.contributor.authorChua, SE
 
dc.contributor.authorOosterlaan, J
 
dc.contributor.authorHung, SF
 
dc.contributor.authorTang, CP
 
dc.contributor.authorLee, CC
 
dc.contributor.authorKwong, SL
 
dc.contributor.authorHo, TP
 
dc.contributor.authorCheung, C
 
dc.contributor.authorSuckling, J
 
dc.contributor.authorLeung, PWL
 
dc.date.accessioned2012-01-20T09:00:52Z
 
dc.date.available2012-01-20T09:00:52Z
 
dc.date.issued2009
 
dc.description.abstractBackground Children with attention-deficit hyperactivity disorder (ADHD) have difficulties with executive function and impulse control which may improve with age. Aims To map the brain correlates of executive function in ADHD and determine age-related changes in reaction times and brain volumes. Method Attention-deficit hyperactivity disorder and control groups were compared on the change task measures of response inhibition (stop signal reaction time, SSRT) and shifting (change response reaction time, CRRT). voxel-wise magnetic resonance imaging (MRI) correlations of reaction times and grey matter volume were determined, along with bivariate correlations of reaction times, brain volumes and age.Results Individuals in the ADHD group had longer SSRTs and CRRTs. Anterior cingulate, striatal and medial temporal volumes highly correlated with SSRT. Striatal and cerebellar volumes strongly correlated with CRRT. Older children had faster reaction times and larger regional brain volumes. In controls, orbitofrontal, medial temporal and cerebellar volumes correlated with CRRT but not SSRT. Neither reaction times nor regional brain volumes were strongly age- dependent. Conclusions Our evidence supports delayed brain maturation in ADHD and implies that some features of ADHD improve with age.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationBritish Journal Of Psychiatry, 2009, v. 194 n. 2, p. 123-129 [How to Cite?]
DOI: http://dx.doi.org/10.1192/bjp.bp.108.051359
 
dc.identifier.doihttp://dx.doi.org/10.1192/bjp.bp.108.051359
 
dc.identifier.eissn1472-1465
 
dc.identifier.epage129
 
dc.identifier.isiWOS:000263338300006
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

study was supported by a University of Hong Kong Grant to S.E.C. The authors would like to thank Ms Michelle Deng for her help with figure preparation.

 
dc.identifier.issn0007-1250
2012 Impact Factor: 6.606
2012 SCImago Journal Rankings: 2.524
 
dc.identifier.issue2
 
dc.identifier.pmid19182173
 
dc.identifier.scopuseid_2-s2.0-60149090875
 
dc.identifier.spage123
 
dc.identifier.urihttp://hdl.handle.net/10722/144319
 
dc.identifier.volume194
 
dc.languageeng
 
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBritish Journal of Psychiatry
 
dc.relation.referencesReferences in Scopus
 
dc.titleAge-related grey matter volume correlates of response inhibition and shifting in attention- Deficit hyperactivity disorder
 
dc.typeArticle
 
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<contributor.author>Oosterlaan, J</contributor.author>
<contributor.author>Hung, SF</contributor.author>
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Author Affiliations
  1. University of Hong Kong
  2. Kwai Chung Hospital
  3. The University of Hong Kong
  4. University of Cambridge
  5. Vrije Universiteit Amsterdam
  6. Chinese University of Hong Kong