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Article: Sex differences in patients with schizophrenia: A prospective, multi-center study

TitleSex differences in patients with schizophrenia: A prospective, multi-center study
Authors
KeywordsBody mass index
China
Schizophrenia
Sex differences
Smoking
Issue Date2010
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
Citation
Psychiatry Research, 2010, v. 177 n. 3, p. 294-298 How to Cite?
AbstractThis study aimed to determine sex differences in socio-demographic and clinical characteristics of Chinese schizophrenia patients. In a multi-center, randomized, controlled, longitudinal study, 404 clinically stable patients with schizophrenia were randomly assigned to a maintenance group (optimal therapeutic doses continued throughout the study), a 26-week group (optimal therapeutic doses continued for 26. weeks, followed by a 50% dose reduction maintained until the end of the study), or a 4-week group (optimal therapeutic doses continued for 4. weeks, followed by a 50% dose reduction maintained until the end of the study). Participants were interviewed regularly using standardized assessment instruments, and followed up for 12-26. months. In the univariate analyses, the following factors were significantly associated with the male sex: not married, smoking, younger age, earlier age at onset, higher body mass index (BMI) at baseline, and more severe negative and hostility-excitement symptoms at baseline. The following factors were independently associated with the male sex in the multivariate analyses: not being married, smoking, a higher BMI at baseline, less deterioration in disorganized thoughts (4-week group) and positive symptoms (26-week group) and less increase in BMI in all three treatment groups over the study period. The majority of the sex differences in schizophrenia patients in this study are in accordance with results of previous studies worldwide suggesting that sex differences seen in schizophrenia are not dependent on cultural differences between geographically separate patients. © 2010 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/144297
ISSN
2015 Impact Factor: 2.466
2015 SCImago Journal Rankings: 1.235
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30800367
Beijing Municipal Science and Technology Commission2008859
10th National Five-Year Plan Foundation of the Ministry of Science and Technology Program, China2004BA720A22
Research Foundation of the Xian-Janssen Pharmaceutical CompanyRIS-CN-MCCT-0201
Funding Information:

This study was supported by grants from the National Natural Science Foundation of China (no. 30800367), Beijing Nova Program of the Beijing Municipal Science and Technology Commission (no. 2008859), 10th National Five-Year Plan Foundation of the Ministry of Science and Technology Program, China (no. 2004BA720A22), and Research Foundation of the Xian-Janssen Pharmaceutical Company (no. RIS-CN-MCCT-0201).

References

 

DC FieldValueLanguage
dc.contributor.authorXiang, YTen_HK
dc.contributor.authorWang, CYen_HK
dc.contributor.authorWeng, YZen_HK
dc.contributor.authorBo, QJen_HK
dc.contributor.authorChiu, HFKen_HK
dc.contributor.authorZhao, JPen_HK
dc.contributor.authorLiu, TQen_HK
dc.contributor.authorChan, SSMen_HK
dc.contributor.authorLee, EHMen_HK
dc.contributor.authorUngvari, GSen_HK
dc.date.accessioned2012-01-20T09:00:20Z-
dc.date.available2012-01-20T09:00:20Z-
dc.date.issued2010en_HK
dc.identifier.citationPsychiatry Research, 2010, v. 177 n. 3, p. 294-298en_HK
dc.identifier.issn0165-1781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144297-
dc.description.abstractThis study aimed to determine sex differences in socio-demographic and clinical characteristics of Chinese schizophrenia patients. In a multi-center, randomized, controlled, longitudinal study, 404 clinically stable patients with schizophrenia were randomly assigned to a maintenance group (optimal therapeutic doses continued throughout the study), a 26-week group (optimal therapeutic doses continued for 26. weeks, followed by a 50% dose reduction maintained until the end of the study), or a 4-week group (optimal therapeutic doses continued for 4. weeks, followed by a 50% dose reduction maintained until the end of the study). Participants were interviewed regularly using standardized assessment instruments, and followed up for 12-26. months. In the univariate analyses, the following factors were significantly associated with the male sex: not married, smoking, younger age, earlier age at onset, higher body mass index (BMI) at baseline, and more severe negative and hostility-excitement symptoms at baseline. The following factors were independently associated with the male sex in the multivariate analyses: not being married, smoking, a higher BMI at baseline, less deterioration in disorganized thoughts (4-week group) and positive symptoms (26-week group) and less increase in BMI in all three treatment groups over the study period. The majority of the sex differences in schizophrenia patients in this study are in accordance with results of previous studies worldwide suggesting that sex differences seen in schizophrenia are not dependent on cultural differences between geographically separate patients. © 2010 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresen_HK
dc.relation.ispartofPsychiatry Researchen_HK
dc.subjectBody mass indexen_HK
dc.subjectChinaen_HK
dc.subjectSchizophreniaen_HK
dc.subjectSex differencesen_HK
dc.subjectSmokingen_HK
dc.titleSex differences in patients with schizophrenia: A prospective, multi-center studyen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, EHM: edwinlhm@hku.hken_HK
dc.identifier.authorityLee, EHM=rp01575en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.psychres.2010.03.014en_HK
dc.identifier.pmid20417572-
dc.identifier.scopuseid_2-s2.0-77952674831en_HK
dc.identifier.hkuros224712-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952674831&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume177en_HK
dc.identifier.issue3en_HK
dc.identifier.spage294en_HK
dc.identifier.epage298en_HK
dc.identifier.isiWOS:000278659600004-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridXiang, YT=35241398400en_HK
dc.identifier.scopusauthoridWang, CY=35345843000en_HK
dc.identifier.scopusauthoridWeng, YZ=7103320159en_HK
dc.identifier.scopusauthoridBo, QJ=35799418800en_HK
dc.identifier.scopusauthoridChiu, HFK=24447976700en_HK
dc.identifier.scopusauthoridZhao, JP=17344801500en_HK
dc.identifier.scopusauthoridLiu, TQ=7405913770en_HK
dc.identifier.scopusauthoridChan, SSM=13409371900en_HK
dc.identifier.scopusauthoridLee, EHM=7406967099en_HK
dc.identifier.scopusauthoridUngvari, GS=7006092063en_HK
dc.identifier.citeulike7109391-

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