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Article: Metabolic profile of first and second generation antipsychotics among Chinese patients

TitleMetabolic profile of first and second generation antipsychotics among Chinese patients
Authors
KeywordsChlorpromazine
Dyslipidemia
Haloperidol
Olanzapine
Risperidone
Trifluoperazine
Ziprasidone
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
Citation
Psychiatry Research, 2011, v. 185 n. 3, p. 456-458 How to Cite?
AbstractThe metabolic profiles of Chinese patients treated with second-generation antipsychotic (SGA) medication and first-generation antipsychotic (FGA) medication were compared. The sample comprised 99 patients treated with SGA (risperidone, olanzapine and ziprasidone) and 99 with FGA (chlorpromazine, haloperidol and trifluoperazine) from the outpatient clinic of a teaching hospital in Hong Kong. The most frequent psychiatric diagnosis was schizophrenia, followed by affective disorder and other psychiatric diagnoses. Subjects were measured for body weight, body height, fasting lipid and glucose levels. SGA was associated with higher LDL-cholesterol level than FGA. Individual comparison of different antipsychotics showed that patients on olanzapine had the greatest increases in cholesterol and triglycerides among all antipsychotics. The finding suggested SGA, particularly olanzapine, were associated with more metabolic risk factors than first-generation antipsychotics. © 2010 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/144294
ISSN
2015 Impact Factor: 2.466
2015 SCImago Journal Rankings: 1.235
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, Een_HK
dc.contributor.authorChow, LYen_HK
dc.contributor.authorLeung, CMen_HK
dc.date.accessioned2012-01-20T09:00:17Z-
dc.date.available2012-01-20T09:00:17Z-
dc.date.issued2011en_HK
dc.identifier.citationPsychiatry Research, 2011, v. 185 n. 3, p. 456-458en_HK
dc.identifier.issn0165-1781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144294-
dc.description.abstractThe metabolic profiles of Chinese patients treated with second-generation antipsychotic (SGA) medication and first-generation antipsychotic (FGA) medication were compared. The sample comprised 99 patients treated with SGA (risperidone, olanzapine and ziprasidone) and 99 with FGA (chlorpromazine, haloperidol and trifluoperazine) from the outpatient clinic of a teaching hospital in Hong Kong. The most frequent psychiatric diagnosis was schizophrenia, followed by affective disorder and other psychiatric diagnoses. Subjects were measured for body weight, body height, fasting lipid and glucose levels. SGA was associated with higher LDL-cholesterol level than FGA. Individual comparison of different antipsychotics showed that patients on olanzapine had the greatest increases in cholesterol and triglycerides among all antipsychotics. The finding suggested SGA, particularly olanzapine, were associated with more metabolic risk factors than first-generation antipsychotics. © 2010 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresen_HK
dc.relation.ispartofPsychiatry Researchen_HK
dc.subjectChlorpromazineen_HK
dc.subjectDyslipidemiaen_HK
dc.subjectHaloperidolen_HK
dc.subjectOlanzapineen_HK
dc.subjectRisperidoneen_HK
dc.subjectTrifluoperazineen_HK
dc.subjectZiprasidoneen_HK
dc.titleMetabolic profile of first and second generation antipsychotics among Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, E: edwinlhm@hku.hken_HK
dc.identifier.authorityLee, E=rp01575en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.psychres.2010.04.050en_HK
dc.identifier.pmid20554016-
dc.identifier.scopuseid_2-s2.0-79251600810en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79251600810&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume185en_HK
dc.identifier.issue3en_HK
dc.identifier.spage456en_HK
dc.identifier.epage458en_HK
dc.identifier.isiWOS:000287467200027-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLee, E=7406967099en_HK
dc.identifier.scopusauthoridChow, LY=36738639300en_HK
dc.identifier.scopusauthoridLeung, CM=7402612698en_HK
dc.identifier.citeulike7393356-

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