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Article: Alternative gene therapy strategies for the repair of craniofacial bone defects

TitleAlternative gene therapy strategies for the repair of craniofacial bone defects
Authors
Issue Date2004
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cgt/index.htm
Citation
Current Gene Therapy, 2004, v. 4 n. 4, p. 469-485 How to Cite?
AbstractCraniofacial anomalies, bone defects and cartilage lesions pose a difficult and challenging problem for both the doctor and for patients and their families. Conventional therapies focus on orthopaedic surgery, grafting with autogenous bone, allogenic bone grafts, or distraction osteogenesis. However, the efficacy of these techniques is limited by high cost, donor morbidity, scarcity of tissue resources, and alterations in volume [Marx & Morales, 1988]. On the basis of recent insights into the development, growth, and adaptation of bone, together with the significant advances in recombinant DNA technology, gene therapy is increasingly becoming recognised as an alternative technique for augmenting and promoting bone regeneration in vivo. It can be applied in craniofacial skeletal tissues by transferring genes encoding for specific growth factors such as BMPs in osteoblasts, chondrocytes or progenitor cells for the purpose of enhancing protein production [Scaduto & Lieberman, 1999]. It can be performed by either direct administration of gene delivery vectors, or by transplantation of genetically modified cells. This review will focus on recent advances in molecular mechanisms of bone formation, and development in various viral and non-viral vectors for direct in vivo therapeutic gene transfer and genetically engineered cells ex vivo therapy. © 2004 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/144275
ISSN
2015 Impact Factor: 2.738
2015 SCImago Journal Rankings: 1.095
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDai, Jen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorHägg, Uen_HK
dc.contributor.authorXu, Ren_HK
dc.date.accessioned2012-01-20T08:58:44Z-
dc.date.available2012-01-20T08:58:44Z-
dc.date.issued2004en_HK
dc.identifier.citationCurrent Gene Therapy, 2004, v. 4 n. 4, p. 469-485en_HK
dc.identifier.issn1566-5232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144275-
dc.description.abstractCraniofacial anomalies, bone defects and cartilage lesions pose a difficult and challenging problem for both the doctor and for patients and their families. Conventional therapies focus on orthopaedic surgery, grafting with autogenous bone, allogenic bone grafts, or distraction osteogenesis. However, the efficacy of these techniques is limited by high cost, donor morbidity, scarcity of tissue resources, and alterations in volume [Marx & Morales, 1988]. On the basis of recent insights into the development, growth, and adaptation of bone, together with the significant advances in recombinant DNA technology, gene therapy is increasingly becoming recognised as an alternative technique for augmenting and promoting bone regeneration in vivo. It can be applied in craniofacial skeletal tissues by transferring genes encoding for specific growth factors such as BMPs in osteoblasts, chondrocytes or progenitor cells for the purpose of enhancing protein production [Scaduto & Lieberman, 1999]. It can be performed by either direct administration of gene delivery vectors, or by transplantation of genetically modified cells. This review will focus on recent advances in molecular mechanisms of bone formation, and development in various viral and non-viral vectors for direct in vivo therapeutic gene transfer and genetically engineered cells ex vivo therapy. © 2004 Bentham Science Publishers Ltd.en_HK
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cgt/index.htmen_HK
dc.relation.ispartofCurrent Gene Therapyen_HK
dc.subject.meshAdenoviridae - geneticsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Regeneration - genetics - physiologyen_HK
dc.subject.meshChondrocytes - metabolismen_HK
dc.subject.meshCraniofacial Abnormalities - therapyen_HK
dc.subject.meshDependovirus - geneticsen_HK
dc.subject.meshGene Therapy - methodsen_HK
dc.subject.meshGene Transfer Techniquesen_HK
dc.subject.meshGenetic Engineeringen_HK
dc.subject.meshGenetic Vectorsen_HK
dc.subject.meshGrowth Substances - genetics - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshOsteoblasts - metabolismen_HK
dc.subject.meshOsteogenesisen_HK
dc.subject.meshRetroviridae - geneticsen_HK
dc.subject.meshTranscription Factors - genetics - physiologyen_HK
dc.subject.meshTransduction, Geneticen_HK
dc.titleAlternative gene therapy strategies for the repair of craniofacial bone defectsen_HK
dc.typeArticleen_HK
dc.identifier.emailDai, J:en_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityDai, J=rp01569en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15578995-
dc.identifier.scopuseid_2-s2.0-8844219656en_HK
dc.identifier.hkuros95705-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8844219656&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue4en_HK
dc.identifier.spage469en_HK
dc.identifier.epage485en_HK
dc.identifier.isiWOS:000225151300010-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridDai, J=35387686200en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK
dc.identifier.scopusauthoridXu, R=7402813857en_HK

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