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Article: The use of recombinant adeno-associated virus for skeletal gene therapy.

TitleThe use of recombinant adeno-associated virus for skeletal gene therapy.
Authors
Issue Date2007
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1601-6335&site=1
Citation
Orthodontics & Craniofacial Research, 2007, v. 10 n. 1, p. 1-14 How to Cite?
AbstractOBJECTIVES: To provide a comprehensive literature review describing recent developments of the recombinant adeno-associated virus (rAAV) vector and exploring the therapeutic application of rAAV for bone defects, cartilage lesions and rheumatoid arthritis. DESIGN: Narrative review. RESULT: The review outlines the serotypes and genome of AAV, integration and life cycle of the rAAV vectors, the immune response and regulating system for AAV gene therapy. Furthermore, the advancements of rAAV gene therapy for bone growth together with cartilage repair are summarized. CONCLUSION: Recombinant adeno-associated virus vector is perceived to be one of the most promising vector systems for bone and cartilage gene therapy approaches and further investigations need to be carried out for craniofacial research.
Persistent Identifierhttp://hdl.handle.net/10722/144273
ISSN
2015 Impact Factor: 1.64
2015 SCImago Journal Rankings: 0.881
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDai, Jen_HK
dc.contributor.authorRabie, ABen_HK
dc.date.accessioned2012-01-20T08:58:40Z-
dc.date.available2012-01-20T08:58:40Z-
dc.date.issued2007en_HK
dc.identifier.citationOrthodontics & Craniofacial Research, 2007, v. 10 n. 1, p. 1-14en_HK
dc.identifier.issn1601-6335en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144273-
dc.description.abstractOBJECTIVES: To provide a comprehensive literature review describing recent developments of the recombinant adeno-associated virus (rAAV) vector and exploring the therapeutic application of rAAV for bone defects, cartilage lesions and rheumatoid arthritis. DESIGN: Narrative review. RESULT: The review outlines the serotypes and genome of AAV, integration and life cycle of the rAAV vectors, the immune response and regulating system for AAV gene therapy. Furthermore, the advancements of rAAV gene therapy for bone growth together with cartilage repair are summarized. CONCLUSION: Recombinant adeno-associated virus vector is perceived to be one of the most promising vector systems for bone and cartilage gene therapy approaches and further investigations need to be carried out for craniofacial research.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1601-6335&site=1en_HK
dc.relation.ispartofOrthodontics & craniofacial researchen_HK
dc.subject.meshArthritis, Rheumatoid - therapyen_HK
dc.subject.meshBone Diseases - therapyen_HK
dc.subject.meshCartilage Diseases - therapyen_HK
dc.subject.meshDNA, Recombinant - genetics - therapeutic useen_HK
dc.subject.meshDependovirus - geneticsen_HK
dc.subject.meshGene Therapy - methodsen_HK
dc.subject.meshGenetic Vectors - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshVirus Integration - geneticsen_HK
dc.titleThe use of recombinant adeno-associated virus for skeletal gene therapy.en_HK
dc.typeArticleen_HK
dc.identifier.emailDai, J:en_HK
dc.identifier.emailRabie, AB: rabie@hku.hken_HK
dc.identifier.authorityDai, J=rp01569en_HK
dc.identifier.authorityRabie, AB=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1601-6343.2007.00381.xen_HK
dc.identifier.pmid17284242-
dc.identifier.scopuseid_2-s2.0-34047177517en_HK
dc.identifier.hkuros135846-
dc.identifier.volume10en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage14en_HK
dc.identifier.isiWOS:000253382300001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDai, J=35387686200en_HK
dc.identifier.scopusauthoridRabie, AB=7007172734en_HK

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