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Article: Recombinant Adeno-Associated Virus Vector Hybrids Efficiently Target Different Skeletal Cells

TitleRecombinant Adeno-Associated Virus Vector Hybrids Efficiently Target Different Skeletal Cells
Authors
Issue Date2007
PublisherFrontiers in Bioscience
Citation
Frontiers In Bioscience, 2007, v. 12 n. 11, p. 4280-4287 How to Cite?
AbstractFinding The Optimal Recombinant Adeno-Associated Virus (Raav) Serotypes For Efficient As Well As Tissue Specific Transduction Has Become Imperative For Successful Gene Therapy. We Used Rat Condylar Chondrocytes, Osteoblast-Like Cell Line Umr106 And Bone Marrow Stromal Cells (Bmscs) To Evaluate The Transduction Efficiency Of Different Raav Serotypes In Vitro; Hoping To Establish An Efficient In Vivo Raav Mediated Delivery System For Gene Therapy In Craniofacial Region. All Of The Selected Raav Serotypes Were Able To Infect Target Cells And Gave Rise To Egfp Expression And Vegf Secretion. Quantified By Fluorescence Activated Cell Sorter (Facs) And Elisa Analysis, Raav2 Was Superior For Efficient Transduction Of Rat Chondrocytes, Raav1 Was Most Efficient When Introduced Into Umr 106 Cell Line And Raav5 Yielded The Highest Infection Efficiency In Bmscs. Hence, Differences In Receptor Binding In Different Oral Tissues And Transduction Pathways Suggest Raav Based Hybrids Have Various Transduction Efficiencies And Can Efficiently Target Different Oral Tissues.
Persistent Identifierhttp://hdl.handle.net/10722/144272
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDai, Jen_US
dc.contributor.authorRabie, ABMen_US
dc.date.accessioned2012-01-20T08:58:39Z-
dc.date.available2012-01-20T08:58:39Z-
dc.date.issued2007en_US
dc.identifier.citationFrontiers In Bioscience, 2007, v. 12 n. 11, p. 4280-4287en_US
dc.identifier.issn1093-9946en_US
dc.identifier.urihttp://hdl.handle.net/10722/144272-
dc.description.abstractFinding The Optimal Recombinant Adeno-Associated Virus (Raav) Serotypes For Efficient As Well As Tissue Specific Transduction Has Become Imperative For Successful Gene Therapy. We Used Rat Condylar Chondrocytes, Osteoblast-Like Cell Line Umr106 And Bone Marrow Stromal Cells (Bmscs) To Evaluate The Transduction Efficiency Of Different Raav Serotypes In Vitro; Hoping To Establish An Efficient In Vivo Raav Mediated Delivery System For Gene Therapy In Craniofacial Region. All Of The Selected Raav Serotypes Were Able To Infect Target Cells And Gave Rise To Egfp Expression And Vegf Secretion. Quantified By Fluorescence Activated Cell Sorter (Facs) And Elisa Analysis, Raav2 Was Superior For Efficient Transduction Of Rat Chondrocytes, Raav1 Was Most Efficient When Introduced Into Umr 106 Cell Line And Raav5 Yielded The Highest Infection Efficiency In Bmscs. Hence, Differences In Receptor Binding In Different Oral Tissues And Transduction Pathways Suggest Raav Based Hybrids Have Various Transduction Efficiencies And Can Efficiently Target Different Oral Tissues.en_US
dc.languageengen_US
dc.publisherFrontiers in Bioscienceen_US
dc.relation.ispartofFrontiers In Bioscienceen_US
dc.titleRecombinant Adeno-Associated Virus Vector Hybrids Efficiently Target Different Skeletal Cellsen_US
dc.typeArticleen_US
dc.identifier.authorityDai, J=rp01569en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2741/2387en_US
dc.identifier.pmid17485374-
dc.identifier.scopuseid_2-s2.0-34347239641en_US
dc.identifier.hkuros135848-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34347239641&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue11en_US
dc.identifier.spage4280en_US
dc.identifier.epage4287en_US
dc.identifier.isiWOS:000246157900117-

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