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Article: Synthesis And Characterization Of Plga-Gelatin Complex With Growth Factor Incorporation As Potential Matrix

TitleSynthesis And Characterization Of Plga-Gelatin Complex With Growth Factor Incorporation As Potential Matrix
Authors
KeywordsFibroblasts
Gelatin
Growth Factor
Matrix
Plga
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jallcom
Citation
Journal Of Alloys And Compounds, 2009, v. 474 n. 1-2, p. 450-454 How to Cite?
AbstractThe Study Was To Fabricate A Novel Hybrid Poly(D,L-Lactic-Co-Glycolic Acid) (Plga) And Gelatin Scaffold And Evaluate Its Potentials As Matrices Of Human Skin Fibroblasts. The Prolonged, Site-Specific Microparticles Loaded With Growth Factor Were Produced As Delivery Vehicles And Were Incorporated With Scaffold To Mimic The Fibroblast-Related Extracellular Matrix (Ecm). The In Vitro Release Efficiency Of Delivery Microparticles Illustrated That Basic Fibroblast Growth Factor (Bfgf) Was Released In A Controlled Manner And The Ultimate Accumulated Release Was Approximately 88.7% By Day 14, Indicating An Extended Time Course For Complete Release. The Behaviors Of The Fibroblasts On The Plga-Gelatin Hybrid Matrix With And Without Bfgf-Loaded Gelatin Microparticles Were Compared. The Efficiency Of Cell Seeding Was Much Higher And The Cells Grew More Quickly In The Matrix With Microparticles Than In The Matrix Without Microparticles. Implantation Studies Of Cultured Implants Indicated That The Cell-Scaffold Constructs Formed A Uniform Layer Of Dermal Tissue Having Almost The Same Thickness As That Of Normal Skin. Dermal Tissues Were Formed After 2 Weeks And Became Epithelialized After 4 Weeks. The Results Indicate That Plga-Gelatin Complex Incorporated With Growth Factor Microparticles Increased The Efficiency Of Cell Seeding, Improved Cell Proliferation, And Therefore Facilitated Rapid Formation Of Dermal Tissue, And It May Be A Promising Candidate As An Artificial Matrix. © 2008 Elsevier B.V. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/144266
ISSN
2015 Impact Factor: 3.014
2015 SCImago Journal Rankings: 1.006
ISI Accession Number ID
Funding AgencyGrant Number
Shaanxi Provincial Natural Science Foundation of China2006C249
Funding Information:

This work was supported by the funding support from Shaanxi Provincial Natural Science Foundation of China (2006C249).

References

 

DC FieldValueLanguage
dc.contributor.authorGu, Zen_US
dc.contributor.authorKong, Len_US
dc.contributor.authorFeng, Xen_US
dc.contributor.authorGuo, Ten_US
dc.contributor.authorDai, Jen_US
dc.contributor.authorLi, Sen_US
dc.contributor.authorHuo, Nen_US
dc.contributor.authorDing, Yen_US
dc.date.accessioned2012-01-20T08:58:30Z-
dc.date.available2012-01-20T08:58:30Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Alloys And Compounds, 2009, v. 474 n. 1-2, p. 450-454en_US
dc.identifier.issn0925-8388en_US
dc.identifier.urihttp://hdl.handle.net/10722/144266-
dc.description.abstractThe Study Was To Fabricate A Novel Hybrid Poly(D,L-Lactic-Co-Glycolic Acid) (Plga) And Gelatin Scaffold And Evaluate Its Potentials As Matrices Of Human Skin Fibroblasts. The Prolonged, Site-Specific Microparticles Loaded With Growth Factor Were Produced As Delivery Vehicles And Were Incorporated With Scaffold To Mimic The Fibroblast-Related Extracellular Matrix (Ecm). The In Vitro Release Efficiency Of Delivery Microparticles Illustrated That Basic Fibroblast Growth Factor (Bfgf) Was Released In A Controlled Manner And The Ultimate Accumulated Release Was Approximately 88.7% By Day 14, Indicating An Extended Time Course For Complete Release. The Behaviors Of The Fibroblasts On The Plga-Gelatin Hybrid Matrix With And Without Bfgf-Loaded Gelatin Microparticles Were Compared. The Efficiency Of Cell Seeding Was Much Higher And The Cells Grew More Quickly In The Matrix With Microparticles Than In The Matrix Without Microparticles. Implantation Studies Of Cultured Implants Indicated That The Cell-Scaffold Constructs Formed A Uniform Layer Of Dermal Tissue Having Almost The Same Thickness As That Of Normal Skin. Dermal Tissues Were Formed After 2 Weeks And Became Epithelialized After 4 Weeks. The Results Indicate That Plga-Gelatin Complex Incorporated With Growth Factor Microparticles Increased The Efficiency Of Cell Seeding, Improved Cell Proliferation, And Therefore Facilitated Rapid Formation Of Dermal Tissue, And It May Be A Promising Candidate As An Artificial Matrix. © 2008 Elsevier B.V. All Rights Reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jallcomen_US
dc.relation.ispartofJournal Of Alloys And Compoundsen_US
dc.subjectFibroblastsen_US
dc.subjectGelatinen_US
dc.subjectGrowth Factoren_US
dc.subjectMatrixen_US
dc.subjectPlgaen_US
dc.titleSynthesis And Characterization Of Plga-Gelatin Complex With Growth Factor Incorporation As Potential Matrixen_US
dc.typeArticleen_US
dc.identifier.authorityDai, J=rp01569en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jallcom.2008.06.150en_US
dc.identifier.scopuseid_2-s2.0-61649091092en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61649091092&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume474en_US
dc.identifier.issue1-2en_US
dc.identifier.spage450en_US
dc.identifier.epage454en_US
dc.identifier.isiWOS:000266952000093-

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