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Article: Effect Of Recombinant Human Bone Morphogenetic Protein-7 On Proliferation And Differentiation Of Human Periodontal Ligament Cells

TitleEffect Of Recombinant Human Bone Morphogenetic Protein-7 On Proliferation And Differentiation Of Human Periodontal Ligament Cells
Authors
KeywordsBone Morphogenetic Protein-7
Human Periodontal Ligament Cells
Remodeling Of Periodontal Tissue
Issue Date2009
Citation
Journal Of Jilin University Medicine Edition, 2009, v. 35 n. 4, p. 677-680 How to Cite?
AbstractObjective: To Study The Effect Of Recombinant Human Bone Morphogenetic Protein-7 (Rhbmp-7) On Proliferation And Differentiation Of Human Periodontal Ligament Cells (Hpdlcs) Cultivated In Vitro. Methods: The Hpdlcs Were Tested Vimentin Positive And Ck (Pan) Negative. Different Dosages (50, 100, 200 And 400 Μmol·L-1) Of Rhbmp-7 Were Added In The Cultured Hpdlcs. 1, 3, 5 D After Administration Of Rhbmp-7, The Proliferation And Osteogenic Differentiation Of Hpdlcs Were Examined By Mtt Assay And The Activity Of Alkaline Phosphatase (Alp) Was Detected With Elisa. Results: The Administration Of Rhbmp-7 Significantly Elevated The Proliferation Rate And Differentiation Of Hpdlcs With The Dosage Of 100, 200 And 400 Μmol·L-1 Respectively (P< 0.01), No Difference Was Found Between Different Dosages Groups (P>0.05). Moreover, Rhbmp-7 Significantly Induced The Osteogenic Differentiation Ability With The Increased Expression Level Of Alp And 200 Μmol·L-1 Was The Most Effective Dosage In The Differentiation Ability. Conclusion: Bmp-7 May Participate In The Remodeling Of Periodontal Tissue By Regulating The Proliferation And Osteogenic Differentiation Of Hpdlcs.
Persistent Identifierhttp://hdl.handle.net/10722/144265
ISSN
2015 SCImago Journal Rankings: 0.106
References

 

DC FieldValueLanguage
dc.contributor.authorJiang, L-Qen_US
dc.contributor.authorChen, Xen_US
dc.contributor.authorCai, L-Sen_US
dc.contributor.authorLiu, J-Len_US
dc.contributor.authorDai, Jen_US
dc.date.accessioned2012-01-20T08:58:30Z-
dc.date.available2012-01-20T08:58:30Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Jilin University Medicine Edition, 2009, v. 35 n. 4, p. 677-680en_US
dc.identifier.issn1671-587Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/144265-
dc.description.abstractObjective: To Study The Effect Of Recombinant Human Bone Morphogenetic Protein-7 (Rhbmp-7) On Proliferation And Differentiation Of Human Periodontal Ligament Cells (Hpdlcs) Cultivated In Vitro. Methods: The Hpdlcs Were Tested Vimentin Positive And Ck (Pan) Negative. Different Dosages (50, 100, 200 And 400 Μmol·L-1) Of Rhbmp-7 Were Added In The Cultured Hpdlcs. 1, 3, 5 D After Administration Of Rhbmp-7, The Proliferation And Osteogenic Differentiation Of Hpdlcs Were Examined By Mtt Assay And The Activity Of Alkaline Phosphatase (Alp) Was Detected With Elisa. Results: The Administration Of Rhbmp-7 Significantly Elevated The Proliferation Rate And Differentiation Of Hpdlcs With The Dosage Of 100, 200 And 400 Μmol·L-1 Respectively (P< 0.01), No Difference Was Found Between Different Dosages Groups (P>0.05). Moreover, Rhbmp-7 Significantly Induced The Osteogenic Differentiation Ability With The Increased Expression Level Of Alp And 200 Μmol·L-1 Was The Most Effective Dosage In The Differentiation Ability. Conclusion: Bmp-7 May Participate In The Remodeling Of Periodontal Tissue By Regulating The Proliferation And Osteogenic Differentiation Of Hpdlcs.en_US
dc.languageengen_US
dc.relation.ispartofJournal Of Jilin University Medicine Editionen_US
dc.subjectBone Morphogenetic Protein-7en_US
dc.subjectHuman Periodontal Ligament Cellsen_US
dc.subjectRemodeling Of Periodontal Tissueen_US
dc.titleEffect Of Recombinant Human Bone Morphogenetic Protein-7 On Proliferation And Differentiation Of Human Periodontal Ligament Cellsen_US
dc.typeArticleen_US
dc.identifier.authorityDai, J=rp01569en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-69049115159en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69049115159&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume35en_US
dc.identifier.issue4en_US
dc.identifier.spage677en_US
dc.identifier.epage680en_US

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