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Article: Correlation Of Estrogen Receptor Alpha Gene Polymorphisms And Bone Mineral Density In Chinese Women With Chronic Periodontitis

TitleCorrelation Of Estrogen Receptor Alpha Gene Polymorphisms And Bone Mineral Density In Chinese Women With Chronic Periodontitis
Authors
Issue Date2010
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 2010, v. 123 n. 22, p. 3262-3267 How to Cite?
AbstractBackground Periodontitis And Osteoporosis Are One Of The Frequently Encountered Diseases In Post-Menopausal Women. Estrogen Receptors (Ers) Regulated Bone Metabolism. To Investigate The Possible Effect Of Er-Alpha (Α) Gene Polymorphisms On Bone Mineral Density (Bmd) In Pre- And Post-Menopausal Chinese Women With Chronic Periodontitis (Cp), We Provided Sufficient Quantitative Information Concerning The Correlation Between Er Gene Polymorphisms And Bmd In Periodontitis. Methods Sixty-Five Post-Menopausal And Eighty Pre-Menopausal Cp Women, And Sixty Post-Menopausal Healthy Individuals Were Recruited In This Study. Genomic Dna Was Extracted From Oral Mucosa Swab Sample Of Each Subject By The Chelex-100 Method. Determination Of The Er-Α Polymorphisms Was Performed By Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (Pcr-Rflp) Technique With Xbai And Pvuii Enzyme. The Index For Periodontal Examination Includes Clinical Attachment Loss (Cal) And Probing Pocket Depth (Ppd). Bmd Was Measured By Dual-Energy X-Ray Absorptiometry (Dexa). Results There Were No Significant Differences Between The Er-Α Genotypes Of Pvuii And Xbai And Bmd In Post-Menopausal And Pre-Menopausal Cp Patients, Respectively (P >0.05). However, There Was Association Between Preand Post-Menopausal Cp Patients At Bmd Of Lumbar Spine L2-L4 (P=0.027) And Ward's Bmd (P=0.004). Furthermore, The Post-Menopausal Cp Women Who Carried Pvuii Tt Genotype Presented Significantly Lower Ward's Bmd Than The Pre-Menopausal Cp Women (P=0.007), Meanwhile, The Post-Menopausal Cp Women Who Carried Xbai Aa Genotype Presented Significantly Lower Spine L2-L4 Bmd Than The Pre-Menopausal Cp Women (P=0.003). Conclusions Er-Α Gene Polymorphisms May Be A Susceptible Indicator For Bmd Variation Of Lumbar Spine L2-L4 And Ward In Chinese Pre- And Post-Menopausal Women Patients With Cp.
Persistent Identifierhttp://hdl.handle.net/10722/144256
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30572069
Funding Information:

This study was supported in part by the a grant from National Natural Science Foundation of China (No 30572069)

References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Xen_US
dc.contributor.authorDai, Jen_US
dc.contributor.authorLong, Yen_US
dc.contributor.authorWu, Hen_US
dc.contributor.authorLi, X-Jen_US
dc.contributor.authorDing, Yen_US
dc.date.accessioned2012-01-20T08:58:25Z-
dc.date.available2012-01-20T08:58:25Z-
dc.date.issued2010en_US
dc.identifier.citationChinese Medical Journal, 2010, v. 123 n. 22, p. 3262-3267en_US
dc.identifier.issn0366-6999en_US
dc.identifier.urihttp://hdl.handle.net/10722/144256-
dc.description.abstractBackground Periodontitis And Osteoporosis Are One Of The Frequently Encountered Diseases In Post-Menopausal Women. Estrogen Receptors (Ers) Regulated Bone Metabolism. To Investigate The Possible Effect Of Er-Alpha (Α) Gene Polymorphisms On Bone Mineral Density (Bmd) In Pre- And Post-Menopausal Chinese Women With Chronic Periodontitis (Cp), We Provided Sufficient Quantitative Information Concerning The Correlation Between Er Gene Polymorphisms And Bmd In Periodontitis. Methods Sixty-Five Post-Menopausal And Eighty Pre-Menopausal Cp Women, And Sixty Post-Menopausal Healthy Individuals Were Recruited In This Study. Genomic Dna Was Extracted From Oral Mucosa Swab Sample Of Each Subject By The Chelex-100 Method. Determination Of The Er-Α Polymorphisms Was Performed By Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (Pcr-Rflp) Technique With Xbai And Pvuii Enzyme. The Index For Periodontal Examination Includes Clinical Attachment Loss (Cal) And Probing Pocket Depth (Ppd). Bmd Was Measured By Dual-Energy X-Ray Absorptiometry (Dexa). Results There Were No Significant Differences Between The Er-Α Genotypes Of Pvuii And Xbai And Bmd In Post-Menopausal And Pre-Menopausal Cp Patients, Respectively (P >0.05). However, There Was Association Between Preand Post-Menopausal Cp Patients At Bmd Of Lumbar Spine L2-L4 (P=0.027) And Ward's Bmd (P=0.004). Furthermore, The Post-Menopausal Cp Women Who Carried Pvuii Tt Genotype Presented Significantly Lower Ward's Bmd Than The Pre-Menopausal Cp Women (P=0.007), Meanwhile, The Post-Menopausal Cp Women Who Carried Xbai Aa Genotype Presented Significantly Lower Spine L2-L4 Bmd Than The Pre-Menopausal Cp Women (P=0.003). Conclusions Er-Α Gene Polymorphisms May Be A Susceptible Indicator For Bmd Variation Of Lumbar Spine L2-L4 And Ward In Chinese Pre- And Post-Menopausal Women Patients With Cp.en_US
dc.languageengen_US
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_US
dc.relation.ispartofChinese Medical Journalen_US
dc.titleCorrelation Of Estrogen Receptor Alpha Gene Polymorphisms And Bone Mineral Density In Chinese Women With Chronic Periodontitisen_US
dc.typeArticleen_US
dc.identifier.authorityDai, J=rp01569en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.3760/cma.j.issn.0366-6999.2010.22.017en_US
dc.identifier.pmid21163127-
dc.identifier.scopuseid_2-s2.0-79251489106en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79251489106&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume123en_US
dc.identifier.issue22en_US
dc.identifier.spage3262en_US
dc.identifier.epage3267en_US
dc.identifier.isiWOS:000284925300017-

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