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Article: Subchondral Bone Loss Following Orthodontically Induced Cartilage Degradation In The Mandibular Condyles Of Rats

TitleSubchondral Bone Loss Following Orthodontically Induced Cartilage Degradation In The Mandibular Condyles Of Rats
Authors
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone
Citation
Bone, 2011, v. 48 n. 2, p. 362-371 How to Cite?
AbstractOsteoarthritis (Oa) Is A Degenerative Joint Disease Generally Characterized By Progressive Cartilage Degradation And Subchondral Bone Changes. Subchondral Bone Changes Have Been Proposed To Initiate Or Accompany With Cartilage Degradation In Oa. The Purpose Of This Study Was To Characterize Cartilage Damage, Subchondral Bone Remodeling, And The Possible Mechanism Involved In These Morphological Changes In Our Reported Rat Model With Oa-Like Lesions In The Mandibular Condyle.In Experimental Groups, The Dental Occlusion Was Orthodontically Disturbed. By Histological Analysis, Transmission Electron Microscopy (Tem), Micro-Ct Scanning And Serum Tests, Changes In Condylar Cartilage And Subchondral Bone Were Analyzed At 8 And 12. Weeks After Treatment. The Mrna And Protein Levels Of Bone Pro-Resorptive And Pro-Formative Factors By Chondrocytes Were Investigated. Increased Degraded Cartilage Areas And Obvious Cartilage Calcification Were Observed In 8- And 12-Week Treated (Exp) Groups Compared To The Age-Matched Controls. Subchondral Bone Loss, Characterized As Decreased Bone Mineral Density (Bmd), Bone Volume Fraction (Bv/Tv) And Trabecular Thickness (Tb.Th), But Increased Trabecular Separation (Tb.Sp), Was Observed In The 12-Week But Not The 8-Week Exp Group, Respectively, Versus Their Age-Matched Controls. The Subchondral Bone Loss In The 12-Week Exp Group Was Accompanied With Decreased New Bone Formation Rate, But Increased Serum Carboxy Terminal Telopeptides (Ctxs), And Increased Osteoclast Numbers And Proportion Of Surface Area In The Subchondral Bone Regions. Increased Mrna And Protein Levels Of M-Csf, Vegf, Runx And Rankl/Opg Ratio, But Decreased Opg, Were Found In Condylar Cartilage In The 12-Week Exp Group Versus Its Age-Matched Controls, And Those Of Rankl/Opg Ratios Were Significantly Higher In The 12-Week Exp Group Than The 8-Week Exp. In Addition, Increased Mrna Levels Of Vegf, Runx And Rankl/Opg Ratio, But Decreased Opg, Were Also Found In Condylar Cartilage In The 8-Week Exp Group Versus Its Age-Matched Controls (All P< 0.05).This Study Demonstrated That Obvious Subchondral Bone Loss Followed Cartilage Degradation In The Mandibular Condyles In The Present Rat Models And Suggested That The Imbalance Of Chondrocyte-Secreted Regulatory Factors Within The Degraded Cartilage May Play A Role In The Osteoclastogenesis, And Thus Leading To The Subchondral Bone Loss In Oa. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/144255
ISSN
2015 Impact Factor: 3.736
2015 SCImago Journal Rankings: 1.752
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30772429
30801315
Funding Information:

We thank Prof. Ling Qin and Dr. Hong-Bin Lu for helpful advice, and Ms. Jia Gao for technic help. This work was supported by grants from the National Natural Science Foundation of China (No. 30772429 and No. 30801315).

References

 

DC FieldValueLanguage
dc.contributor.authorJiao, Ken_US
dc.contributor.authorNiu, L-Nen_US
dc.contributor.authorWang, M-Qen_US
dc.contributor.authorDai, Jen_US
dc.contributor.authorYu, S-Ben_US
dc.contributor.authorLiu, X-Den_US
dc.contributor.authorWang, Jen_US
dc.date.accessioned2012-01-20T08:58:23Z-
dc.date.available2012-01-20T08:58:23Z-
dc.date.issued2011en_US
dc.identifier.citationBone, 2011, v. 48 n. 2, p. 362-371en_US
dc.identifier.issn8756-3282en_US
dc.identifier.urihttp://hdl.handle.net/10722/144255-
dc.description.abstractOsteoarthritis (Oa) Is A Degenerative Joint Disease Generally Characterized By Progressive Cartilage Degradation And Subchondral Bone Changes. Subchondral Bone Changes Have Been Proposed To Initiate Or Accompany With Cartilage Degradation In Oa. The Purpose Of This Study Was To Characterize Cartilage Damage, Subchondral Bone Remodeling, And The Possible Mechanism Involved In These Morphological Changes In Our Reported Rat Model With Oa-Like Lesions In The Mandibular Condyle.In Experimental Groups, The Dental Occlusion Was Orthodontically Disturbed. By Histological Analysis, Transmission Electron Microscopy (Tem), Micro-Ct Scanning And Serum Tests, Changes In Condylar Cartilage And Subchondral Bone Were Analyzed At 8 And 12. Weeks After Treatment. The Mrna And Protein Levels Of Bone Pro-Resorptive And Pro-Formative Factors By Chondrocytes Were Investigated. Increased Degraded Cartilage Areas And Obvious Cartilage Calcification Were Observed In 8- And 12-Week Treated (Exp) Groups Compared To The Age-Matched Controls. Subchondral Bone Loss, Characterized As Decreased Bone Mineral Density (Bmd), Bone Volume Fraction (Bv/Tv) And Trabecular Thickness (Tb.Th), But Increased Trabecular Separation (Tb.Sp), Was Observed In The 12-Week But Not The 8-Week Exp Group, Respectively, Versus Their Age-Matched Controls. The Subchondral Bone Loss In The 12-Week Exp Group Was Accompanied With Decreased New Bone Formation Rate, But Increased Serum Carboxy Terminal Telopeptides (Ctxs), And Increased Osteoclast Numbers And Proportion Of Surface Area In The Subchondral Bone Regions. Increased Mrna And Protein Levels Of M-Csf, Vegf, Runx And Rankl/Opg Ratio, But Decreased Opg, Were Found In Condylar Cartilage In The 12-Week Exp Group Versus Its Age-Matched Controls, And Those Of Rankl/Opg Ratios Were Significantly Higher In The 12-Week Exp Group Than The 8-Week Exp. In Addition, Increased Mrna Levels Of Vegf, Runx And Rankl/Opg Ratio, But Decreased Opg, Were Also Found In Condylar Cartilage In The 8-Week Exp Group Versus Its Age-Matched Controls (All P< 0.05).This Study Demonstrated That Obvious Subchondral Bone Loss Followed Cartilage Degradation In The Mandibular Condyles In The Present Rat Models And Suggested That The Imbalance Of Chondrocyte-Secreted Regulatory Factors Within The Degraded Cartilage May Play A Role In The Osteoclastogenesis, And Thus Leading To The Subchondral Bone Loss In Oa. © 2010 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/boneen_US
dc.relation.ispartofBoneen_US
dc.titleSubchondral Bone Loss Following Orthodontically Induced Cartilage Degradation In The Mandibular Condyles Of Ratsen_US
dc.typeArticleen_US
dc.identifier.authorityDai, J=rp01569en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bone.2010.09.010en_US
dc.identifier.pmid20850574-
dc.identifier.scopuseid_2-s2.0-78650970042en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650970042&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume48en_US
dc.identifier.issue2en_US
dc.identifier.spage362en_US
dc.identifier.epage371en_US
dc.identifier.isiWOS:000286543700025-
dc.identifier.citeulike7855329-

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