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Article: Oxidative damage in ischemic stroke revealed using multiple biomarkers

TitleOxidative damage in ischemic stroke revealed using multiple biomarkers
Authors
Keywords24-hydroxycholesterol
allantoin
F4-neuroprostanes
F 2-isoprostanes
hydroxyeicosatetraenoic acid products
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org
Citation
Stroke, 2011, v. 42 n. 8, p. 2326-2329 How to Cite?
AbstractBackground and Purpose-We investigated changes in oxidative damage after ischemic stroke using multiple biomarkers. Methods-Serial blood and urine samples of ischemic stroke subjects and age-matched control subjects were assayed for F2-isoprostanes, hydroxyeicosatetraenoic acid products, F4-neuroprostanes, 24-hydroxycholesterol, allantoin, and urate. Results-Sixty-six stroke subjects (mean age, 65 years; median National Institutes of Health Stroke Scale 17) and 132 control subjects were recruited. A bimodal pattern of change was observed in plasma and urinary F2-isoprostanes and plasma 24-hydroxycholesterol. The rise in plasma hydroxyeicosatetraenoic acid products, F4-neuroprostanes, and allantoin was highest 6 to 12 hours after stroke onset, whereas plasma urate was significantly lower than controls on Days 1 to 3. After adjusting for age and baseline National Institutes of Health Stroke Scale, baseline plasma esterified hydroxyeicosatetraenoic acid products (OR, 1.01; 95% CI, 1.01 to 1.02), plasma urate (1.01; 1.00 to 1.01), and plasma free F4-neuroprostanes (2.73; 1.76 to 3.93) were associated with 90-day good functional recovery (modified Rankin Scale ≤1). Conclusions-Multiple markers of oxidative damage are increased immediately after stroke and remain elevated for several days. Recognition of these temporal changes may help design better antioxidant treatment trials for acute ischemic stroke. © 2011 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/143938
ISSN
2015 Impact Factor: 5.787
2015 SCImago Journal Rankings: 3.671
ISI Accession Number ID
Funding AgencyGrant Number
National Medical Research Council, SingaporeNMRC/1157/2008
Funding Information:

We acknowledge support from the National Medical Research Council, Singapore (Grant NMRC/1157/2008).

References

 

DC FieldValueLanguage
dc.contributor.authorSeet, RCSen_HK
dc.contributor.authorLee, CYJen_HK
dc.contributor.authorChan, BPLen_HK
dc.contributor.authorSharma, VKen_HK
dc.contributor.authorTeoh, HLen_HK
dc.contributor.authorVenketasubramanian, Nen_HK
dc.contributor.authorLim, ECHen_HK
dc.contributor.authorChong, WLen_HK
dc.contributor.authorLooi, WFen_HK
dc.contributor.authorHuang, SHen_HK
dc.contributor.authorOng, BKCen_HK
dc.contributor.authorHalliwell, Ben_HK
dc.date.accessioned2011-12-21T08:59:40Z-
dc.date.available2011-12-21T08:59:40Z-
dc.date.issued2011en_HK
dc.identifier.citationStroke, 2011, v. 42 n. 8, p. 2326-2329en_HK
dc.identifier.issn0039-2499en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143938-
dc.description.abstractBackground and Purpose-We investigated changes in oxidative damage after ischemic stroke using multiple biomarkers. Methods-Serial blood and urine samples of ischemic stroke subjects and age-matched control subjects were assayed for F2-isoprostanes, hydroxyeicosatetraenoic acid products, F4-neuroprostanes, 24-hydroxycholesterol, allantoin, and urate. Results-Sixty-six stroke subjects (mean age, 65 years; median National Institutes of Health Stroke Scale 17) and 132 control subjects were recruited. A bimodal pattern of change was observed in plasma and urinary F2-isoprostanes and plasma 24-hydroxycholesterol. The rise in plasma hydroxyeicosatetraenoic acid products, F4-neuroprostanes, and allantoin was highest 6 to 12 hours after stroke onset, whereas plasma urate was significantly lower than controls on Days 1 to 3. After adjusting for age and baseline National Institutes of Health Stroke Scale, baseline plasma esterified hydroxyeicosatetraenoic acid products (OR, 1.01; 95% CI, 1.01 to 1.02), plasma urate (1.01; 1.00 to 1.01), and plasma free F4-neuroprostanes (2.73; 1.76 to 3.93) were associated with 90-day good functional recovery (modified Rankin Scale ≤1). Conclusions-Multiple markers of oxidative damage are increased immediately after stroke and remain elevated for several days. Recognition of these temporal changes may help design better antioxidant treatment trials for acute ischemic stroke. © 2011 American Heart Association, Inc.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.orgen_HK
dc.relation.ispartofStrokeen_HK
dc.subject24-hydroxycholesterolen_HK
dc.subjectallantoinen_HK
dc.subjectF4-neuroprostanesen_HK
dc.subjectF 2-isoprostanesen_HK
dc.subjecthydroxyeicosatetraenoic acid productsen_HK
dc.titleOxidative damage in ischemic stroke revealed using multiple biomarkersen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, CYJ: jettylee@hku.hken_HK
dc.identifier.authorityLee, CYJ=rp01511en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1161/STROKEAHA.111.618835en_HK
dc.identifier.pmid21700941-
dc.identifier.scopuseid_2-s2.0-79961207792en_HK
dc.identifier.hkuros197984en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79961207792&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue8en_HK
dc.identifier.spage2326en_HK
dc.identifier.epage2329en_HK
dc.identifier.isiWOS:000293077400045-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSeet, RCS=10045357300en_HK
dc.identifier.scopusauthoridLee, CYJ=13104265200en_HK
dc.identifier.scopusauthoridChan, BPL=35309563700en_HK
dc.identifier.scopusauthoridSharma, VK=7404568704en_HK
dc.identifier.scopusauthoridTeoh, HL=8865199000en_HK
dc.identifier.scopusauthoridVenketasubramanian, N=8243931800en_HK
dc.identifier.scopusauthoridLim, ECH=8945547100en_HK
dc.identifier.scopusauthoridChong, WL=36522496900en_HK
dc.identifier.scopusauthoridLooi, WF=36523459100en_HK
dc.identifier.scopusauthoridHuang, SH=8367750600en_HK
dc.identifier.scopusauthoridOng, BKC=25625394900en_HK
dc.identifier.scopusauthoridHalliwell, B=7101878919en_HK

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