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Article: Dose-Response Relation Between Physical Activity and Cognitive Function: Guangzhou Biobank Cohort Study

TitleDose-Response Relation Between Physical Activity and Cognitive Function: Guangzhou Biobank Cohort Study
Authors
KeywordsCognitive Function
Elderly
International Physical Activity Questionnaire
Physical Activity
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidem
Citation
Annals Of Epidemiology, 2011, v. 21 n. 11, p. 857-863 How to Cite?
Abstract
Purpose: To examine, via cross-sectional analysis, the dose-response association between physical activity and cognitive function in Chinese subjects. Methods: A total of 27,651 participants aged 50 to 85 years were recruited from 2003 to 2008. Information on potential confounders, including demographic and anthropometric characteristics, socioeconomic position, lifestyle, and disease history, was collected by standardized interview and procedures. Cognitive function was assessed by the delayed 10-word recall test (DWRT). Results: When the International Physical Activity Questionnaire was used, we found that most of the participants were classified as physically active (53.1%), with 42.4% moderately active and 4.5% physically inactive. Significant dose-response relations across quintiles of metabolic equivalent value (METs) with DWRT score in participants with or without good self-rated health were found (all p for trend <.001). In participants with poor self-rated heath, compared with the first quintile of METs, those in the fifth quintile (highest METs) had a significantly reduced risk for mild cognitive impairment by 28% (adjusted odds ratio, 0.72; 95% confidence interval, 0.58-0.89, p < .01; p for trend = .006). After additional adjustment for depression, we found that the association between physical activity and DWRT score remained significant. Conclusions: A significant dose-response relationship between physical activity and cognitive function was found, and the association was more pronounced in participants with poor self-rated health. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/143819
ISSN
2013 Impact Factor: 2.145
2013 SCImago Journal Rankings: 1.301
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau, Guangzhou, China
University of Birmingham, Birmingham, United Kingdom
Funding Information:

This work was supported by The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China; and The University of Birmingham, Birmingham, United Kingdom.

References

 

Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Guangzhou No. 12 Hospital
DC FieldValueLanguage
dc.contributor.authorXu, Len_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorZhang, WSen_HK
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorCheng, KKen_HK
dc.date.accessioned2011-12-21T08:56:40Z-
dc.date.available2011-12-21T08:56:40Z-
dc.date.issued2011en_HK
dc.identifier.citationAnnals Of Epidemiology, 2011, v. 21 n. 11, p. 857-863en_HK
dc.identifier.issn1047-2797en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143819-
dc.description.abstractPurpose: To examine, via cross-sectional analysis, the dose-response association between physical activity and cognitive function in Chinese subjects. Methods: A total of 27,651 participants aged 50 to 85 years were recruited from 2003 to 2008. Information on potential confounders, including demographic and anthropometric characteristics, socioeconomic position, lifestyle, and disease history, was collected by standardized interview and procedures. Cognitive function was assessed by the delayed 10-word recall test (DWRT). Results: When the International Physical Activity Questionnaire was used, we found that most of the participants were classified as physically active (53.1%), with 42.4% moderately active and 4.5% physically inactive. Significant dose-response relations across quintiles of metabolic equivalent value (METs) with DWRT score in participants with or without good self-rated health were found (all p for trend <.001). In participants with poor self-rated heath, compared with the first quintile of METs, those in the fifth quintile (highest METs) had a significantly reduced risk for mild cognitive impairment by 28% (adjusted odds ratio, 0.72; 95% confidence interval, 0.58-0.89, p < .01; p for trend = .006). After additional adjustment for depression, we found that the association between physical activity and DWRT score remained significant. Conclusions: A significant dose-response relationship between physical activity and cognitive function was found, and the association was more pronounced in participants with poor self-rated health. © 2011 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/annepidemen_HK
dc.relation.ispartofAnnals of Epidemiologyen_HK
dc.subjectCognitive Functionen_HK
dc.subjectElderlyen_HK
dc.subjectInternational Physical Activity Questionnaireen_HK
dc.subjectPhysical Activityen_HK
dc.subject.meshChina - epidemiology-
dc.subject.meshCognition - physiology-
dc.subject.meshCohort Studies-
dc.subject.meshMild Cognitive Impairment - epidemiology-
dc.subject.meshMotor Activity - physiology-
dc.titleDose-Response Relation Between Physical Activity and Cognitive Function: Guangzhou Biobank Cohort Studyen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.annepidem.2011.06.002en_HK
dc.identifier.pmid21784658en_HK
dc.identifier.scopuseid_2-s2.0-80053562297en_HK
dc.identifier.hkuros198044en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053562297&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue11en_HK
dc.identifier.spage857en_HK
dc.identifier.epage863en_HK
dc.identifier.isiWOS:000296077100009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, L=53878780900en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridZhang, WS=35180743500en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.citeulike9613166-

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