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Article: Isolated low levels of high-density lipoprotein cholesterol are associated with an increased risk of coronary heart disease: An individual participant data meta-analysis of 23 studies in the asia-pacific region

TitleIsolated low levels of high-density lipoprotein cholesterol are associated with an increased risk of coronary heart disease: An individual participant data meta-analysis of 23 studies in the asia-pacific region
Authors
Keywordscardiovascular diseases
cholesterol
epidemiology
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
Circulation, 2011, v. 124 n. 19, p. 2056-2064 How to Cite?
AbstractBackground-: Previous studies have suggested that there is a novel dyslipidemic profile consisting of isolated low high-density lipoprotein cholesterol (HDL-C) level that is associated with increased risk of coronary heart disease, and that this trait may be especially prevalent in Asian populations. Methods and Results-: Individual participant data from 220 060 participants (87% Asian) in 37 studies from the Asia-Pacific region were included. Low HDL-C (HDL <1.03 mmol/L in men and <1.30 mmol/L in women) was seen among 33.1% (95% confidence interval [CI], 32.9-33.3) of Asians versus 27.0% (95% CI, 26.5-27.5) of non-Asians (P<0.001). The prevalence of low HDL-C in the absence of other lipid abnormalities (isolated low HDL-C) was higher in Asians compared with non-Asians: 22.4% (95% CI, 22.2-22.5) versus 14.5% (95% CI, 14.1-14.9), respectively (P<0.001). During 6.8 years of follow-up, there were 574 coronary heart disease and 739 stroke events. There was an inverse relationship between low HDL-C with coronary heart disease in all individuals (hazard ratio, 1.57; 95% CI, 1.31-1.87). In Asians, isolated low levels of HDL-C were as strongly associated with coronary heart disease risk as low levels of HDL-C combined with other lipid abnormalities (hazard ratio, 1.67 [95% CI, 1.27-2.19] versus 1.63 [95% CI, 1.24-2.15], respectively). There was no association between low HDL-C and stroke risk in this population (hazard ratio, 0.95 [95% CI, 0.78 to 1.17] with nonisolated low HDL-C and 0.81 [95% CI, 0.67-1.00] with isolated low HDL-C). Conclusion-: Isolated low HDL-C is a novel lipid phenotype that appears to be more prevalent among Asian populations, in whom it is associated with increased coronary risk. Further investigation into this type of dyslipidemia is warranted. © 2011 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/143814
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853
ISI Accession Number ID
Funding AgencyGrant Number
National Health and Medical Research Council571281
Merck Sharpe and Dohme
Ministry for Health, Welfare and Family Affairs, Republic of Korea0920330
Roche
Funding Information:

This work was funded by National Health and Medical Research Council program grant No. 571281 and by an educational grant from Merck Sharpe and Dohme. Dr Jee was funded by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs, Republic of Korea (0920330).

References

 

DC FieldValueLanguage
dc.contributor.authorHuxley, RRen_HK
dc.contributor.authorBarzi, Fen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorCzernichow, Sen_HK
dc.contributor.authorFang, Xen_HK
dc.contributor.authorWelborn, Ten_HK
dc.contributor.authorShaw, Jen_HK
dc.contributor.authorUeshima, Hen_HK
dc.contributor.authorZimmet, Pen_HK
dc.contributor.authorJee, SHen_HK
dc.contributor.authorPatel, JVen_HK
dc.contributor.authorCaterson, Ien_HK
dc.contributor.authorPerkovic, Ven_HK
dc.contributor.authorWoodward, Men_HK
dc.date.accessioned2011-12-21T08:56:37Z-
dc.date.available2011-12-21T08:56:37Z-
dc.date.issued2011en_HK
dc.identifier.citationCirculation, 2011, v. 124 n. 19, p. 2056-2064en_HK
dc.identifier.issn0009-7322en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143814-
dc.description.abstractBackground-: Previous studies have suggested that there is a novel dyslipidemic profile consisting of isolated low high-density lipoprotein cholesterol (HDL-C) level that is associated with increased risk of coronary heart disease, and that this trait may be especially prevalent in Asian populations. Methods and Results-: Individual participant data from 220 060 participants (87% Asian) in 37 studies from the Asia-Pacific region were included. Low HDL-C (HDL <1.03 mmol/L in men and <1.30 mmol/L in women) was seen among 33.1% (95% confidence interval [CI], 32.9-33.3) of Asians versus 27.0% (95% CI, 26.5-27.5) of non-Asians (P<0.001). The prevalence of low HDL-C in the absence of other lipid abnormalities (isolated low HDL-C) was higher in Asians compared with non-Asians: 22.4% (95% CI, 22.2-22.5) versus 14.5% (95% CI, 14.1-14.9), respectively (P<0.001). During 6.8 years of follow-up, there were 574 coronary heart disease and 739 stroke events. There was an inverse relationship between low HDL-C with coronary heart disease in all individuals (hazard ratio, 1.57; 95% CI, 1.31-1.87). In Asians, isolated low levels of HDL-C were as strongly associated with coronary heart disease risk as low levels of HDL-C combined with other lipid abnormalities (hazard ratio, 1.67 [95% CI, 1.27-2.19] versus 1.63 [95% CI, 1.24-2.15], respectively). There was no association between low HDL-C and stroke risk in this population (hazard ratio, 0.95 [95% CI, 0.78 to 1.17] with nonisolated low HDL-C and 0.81 [95% CI, 0.67-1.00] with isolated low HDL-C). Conclusion-: Isolated low HDL-C is a novel lipid phenotype that appears to be more prevalent among Asian populations, in whom it is associated with increased coronary risk. Further investigation into this type of dyslipidemia is warranted. © 2011 American Heart Association, Inc.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.orgen_HK
dc.relation.ispartofCirculationen_HK
dc.subjectcardiovascular diseasesen_HK
dc.subjectcholesterolen_HK
dc.subjectepidemiologyen_HK
dc.subject.meshAsian Continental Ancestry Group - statistics and numerical data-
dc.subject.meshAustralasia - epidemiology-
dc.subject.meshCholesterol, HDL - blood-
dc.subject.meshCoronary Disease - blood - ethnology-
dc.subject.meshDyslipidemias - blood - ethnology-
dc.titleIsolated low levels of high-density lipoprotein cholesterol are associated with an increased risk of coronary heart disease: An individual participant data meta-analysis of 23 studies in the asia-pacific regionen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1161/CIRCULATIONAHA.111.028373en_HK
dc.identifier.pmid21986289-
dc.identifier.scopuseid_2-s2.0-80855152930en_HK
dc.identifier.hkuros198014en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80855152930&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue19en_HK
dc.identifier.spage2056en_HK
dc.identifier.epage2064en_HK
dc.identifier.isiWOS:000296766800007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuxley, RR=6701828350en_HK
dc.identifier.scopusauthoridBarzi, F=7003545543en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCzernichow, S=35229348600en_HK
dc.identifier.scopusauthoridFang, X=7401433142en_HK
dc.identifier.scopusauthoridWelborn, T=7005408607en_HK
dc.identifier.scopusauthoridShaw, J=35563820200en_HK
dc.identifier.scopusauthoridUeshima, H=7005129002en_HK
dc.identifier.scopusauthoridZimmet, P=52064027900en_HK
dc.identifier.scopusauthoridJee, SH=16039275900en_HK
dc.identifier.scopusauthoridPatel, JV=36630777400en_HK
dc.identifier.scopusauthoridCaterson, I=7005056126en_HK
dc.identifier.scopusauthoridPerkovic, V=22135866300en_HK
dc.identifier.scopusauthoridWoodward, M=7102510958en_HK

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