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Article: Intergenerational influences on diabetes in a developing population: the Guangzhou Biobank Cohort Study

TitleIntergenerational influences on diabetes in a developing population: the Guangzhou Biobank Cohort Study
Authors
Issue Date2011
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1042-0533/
Citation
American Journal of Human Biology, 2011, v. 23 n. 6, p. 747-754 How to Cite?
AbstractOBJECTIVES: Intergenerational 'mismatch' and/or growth conditions may be relevant to the epidemic of diabetes in developing populations. In a rapidly developing southern Chinese population, we tested whether maternal environment, proxied by maternal literacy, or family socio-economic position (SEP), proxied by paternal literacy, were associated with fasting glucose and diabetes. To assess if intergenerational mismatch contributed, we tested whether the associations varied by life course SEP. METHODS: In 19,818 older (>/=50 years) adults from the Guangzhou Biobank Cohort Study (phases 2 and 3), we used censored and logistic regression to assess the associations of maternal and paternal literacy with fasting glucose, elevated fasting glucose and diabetes and whether these associations varied by sex, age or life course SEP. RESULTS: Maternal, but not paternal, literacy was negatively associated with fasting plasma glucose (beta-coefficient -0.06 mmol/l, 95% confidence interval (CI) -0.11 to -0.01) and elevated fasting glucose (odds ratio (OR) 0.92, 95% CI 0.86-0.99) adjusted for age, sex, study phase, life course SEP, childhood growth, adiposity, number of offspring, and birth order. Associations of maternal and paternal literacy with fasting glucose, elevated fasting glucose and diabetes did not vary by sex, age or life course SEP. CONCLUSION: Offspring of literate mothers had lower risk for impaired glucose tolerance than offspring of illiterate mothers. Being raised by literate mothers may increase the likelihood of children with higher SEP and lower long-term disease risk, or better maternal conditions over generations may be associated with lower fasting glucose.
Persistent Identifierhttp://hdl.handle.net/10722/143806
ISSN
2015 Impact Factor: 1.875
2015 SCImago Journal Rankings: 1.018
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKavikondala, Sen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorZhang, WSen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorSchooling, CMen_HK
dc.date.accessioned2011-12-21T08:56:33Z-
dc.date.available2011-12-21T08:56:33Z-
dc.date.issued2011en_HK
dc.identifier.citationAmerican Journal of Human Biology, 2011, v. 23 n. 6, p. 747-754en_HK
dc.identifier.issn1042-0533en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143806-
dc.description.abstractOBJECTIVES: Intergenerational 'mismatch' and/or growth conditions may be relevant to the epidemic of diabetes in developing populations. In a rapidly developing southern Chinese population, we tested whether maternal environment, proxied by maternal literacy, or family socio-economic position (SEP), proxied by paternal literacy, were associated with fasting glucose and diabetes. To assess if intergenerational mismatch contributed, we tested whether the associations varied by life course SEP. METHODS: In 19,818 older (>/=50 years) adults from the Guangzhou Biobank Cohort Study (phases 2 and 3), we used censored and logistic regression to assess the associations of maternal and paternal literacy with fasting glucose, elevated fasting glucose and diabetes and whether these associations varied by sex, age or life course SEP. RESULTS: Maternal, but not paternal, literacy was negatively associated with fasting plasma glucose (beta-coefficient -0.06 mmol/l, 95% confidence interval (CI) -0.11 to -0.01) and elevated fasting glucose (odds ratio (OR) 0.92, 95% CI 0.86-0.99) adjusted for age, sex, study phase, life course SEP, childhood growth, adiposity, number of offspring, and birth order. Associations of maternal and paternal literacy with fasting glucose, elevated fasting glucose and diabetes did not vary by sex, age or life course SEP. CONCLUSION: Offspring of literate mothers had lower risk for impaired glucose tolerance than offspring of illiterate mothers. Being raised by literate mothers may increase the likelihood of children with higher SEP and lower long-term disease risk, or better maternal conditions over generations may be associated with lower fasting glucose.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1042-0533/en_HK
dc.relation.ispartofAmerican Journal of Human Biologyen_HK
dc.rightsAmerican Journal of Human Biology. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshAdiposityen_HK
dc.subject.meshBlood Glucose - analysisen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshDiabetes Mellitus - epidemiology - psychologyen_HK
dc.subject.meshObesity - epidemiologyen_HK
dc.titleIntergenerational influences on diabetes in a developing population: the Guangzhou Biobank Cohort Studyen_HK
dc.typeArticleen_HK
dc.identifier.emailKavikondala, S: sushma@hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hk-
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authoritySchooling, CM=rp00504en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ajhb.21206en_HK
dc.identifier.pmid21987430-
dc.identifier.scopuseid_2-s2.0-80053930569en_HK
dc.identifier.hkuros197997en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053930569&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue6en_HK
dc.identifier.spage747en_HK
dc.identifier.epage754en_HK
dc.identifier.isiWOS:000296140100003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSchooling, CM=12808565000en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridZhang, WS=24464616400en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridKavikondala, S=14819602600en_HK

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