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Article: Influenza associated mortality in the subtropics and tropics: Results from three Asian cities

TitleInfluenza associated mortality in the subtropics and tropics: Results from three Asian cities
Authors
KeywordsCardiorespiratory
Influenza
Mortality
Subtropics
Tropics
Issue Date2011
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2011, v. 29 n. 48, p. 8909-8914 How to Cite?
AbstractInfluenza has been well documented to significantly contribute to winter increase of mortality in the temperate countries, but its severity in the subtropics and tropics was not recognized until recently and geographical variations of disease burden in these regions remain poorly understood. In this study, we applied a standardized modeling strategy to the mortality and virology data from three Asian cities: subtropical Guangzhou and Hong Kong, and tropical Singapore, to estimate the disease burden of influenza in these cities. We found that influenza was associated with 10.6, 13.4 and 8.3 deaths per 100,000 population in Guangzhou, Hong Kong and Singapore, respectively. The annual rates of excess deaths in the elders were estimated highest in Guangzhou and lowest in Singapore. The excess death rate attributable to A/H1N1 subtype was found slightly higher than the rates attributable to A/H3N2 during the study period of 2004-2006 based on the data from Hong Kong and Guangzhou. Our study revealed a geographical variation in the disease burden of influenza in these subtropical and tropical cities. These results highlight a need to explore the determinants for severity of seasonal influenza. © 2011 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/143773
ISSN
2015 Impact Factor: 3.413
2015 SCImago Journal Rankings: 2.044
ISI Accession Number ID
Funding AgencyGrant Number
GlaxoSmithKline
Baxter
Cruxell
Combinatorix
DIVA Solutions
Research Fund for the Control of Infectious Diseases/Health and Health Services Research Fund04050212
University Grants Committee of the Hong Kong Special Administrative RegionAoE/M-12/06
Funding Information:

JSMP declares research support from GlaxoSmithKline, Baxter, Cruxell, Combinatorix, and DIVA Solutions. No other conflicts were declared.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorYang, Len_HK
dc.contributor.authorMa, Sen_HK
dc.contributor.authorChen, PYen_HK
dc.contributor.authorHe, JFen_HK
dc.contributor.authorChan, KPen_HK
dc.contributor.authorChow, Aen_HK
dc.contributor.authorOu, CQen_HK
dc.contributor.authorDeng, APen_HK
dc.contributor.authorHedley, AJen_HK
dc.contributor.authorWong, CMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2011-12-21T08:54:28Z-
dc.date.available2011-12-21T08:54:28Z-
dc.date.issued2011en_HK
dc.identifier.citationVaccine, 2011, v. 29 n. 48, p. 8909-8914en_HK
dc.identifier.issn0264-410Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/143773-
dc.description.abstractInfluenza has been well documented to significantly contribute to winter increase of mortality in the temperate countries, but its severity in the subtropics and tropics was not recognized until recently and geographical variations of disease burden in these regions remain poorly understood. In this study, we applied a standardized modeling strategy to the mortality and virology data from three Asian cities: subtropical Guangzhou and Hong Kong, and tropical Singapore, to estimate the disease burden of influenza in these cities. We found that influenza was associated with 10.6, 13.4 and 8.3 deaths per 100,000 population in Guangzhou, Hong Kong and Singapore, respectively. The annual rates of excess deaths in the elders were estimated highest in Guangzhou and lowest in Singapore. The excess death rate attributable to A/H1N1 subtype was found slightly higher than the rates attributable to A/H3N2 during the study period of 2004-2006 based on the data from Hong Kong and Guangzhou. Our study revealed a geographical variation in the disease burden of influenza in these subtropical and tropical cities. These results highlight a need to explore the determinants for severity of seasonal influenza. © 2011 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccineen_HK
dc.relation.ispartofVaccineen_HK
dc.subjectCardiorespiratoryen_HK
dc.subjectInfluenzaen_HK
dc.subjectMortalityen_HK
dc.subjectSubtropicsen_HK
dc.subjectTropicsen_HK
dc.subject.meshHong Kong - epidemiology-
dc.subject.meshInfluenza A Virus, H3N2 Subtype-
dc.subject.meshInfluenza, Human - mortality-
dc.subject.meshSingapore - epidemiology-
dc.subject.meshTropical Climate-
dc.titleInfluenza associated mortality in the subtropics and tropics: Results from three Asian citiesen_HK
dc.typeArticleen_HK
dc.identifier.emailHedley, AJ: hrmrajh@hkucc.hku.hken_HK
dc.identifier.emailWong, CM: hrmrwcm@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityHedley, AJ=rp00357en_HK
dc.identifier.authorityWong, CM=rp00338en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.vaccine.2011.09.071en_HK
dc.identifier.pmid21959328-
dc.identifier.scopuseid_2-s2.0-82455171859en_HK
dc.identifier.hkuros198033en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-82455171859&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue48en_HK
dc.identifier.spage8909en_HK
dc.identifier.epage8914en_HK
dc.identifier.isiWOS:000297601200019-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectEstimation of the effect of influenza on cardiorespiratory and all causes mortality in tropical and sub-tropical climates - a comparative study between Hong Kong, Singapore and Guangzhou for influence of seasonality and meteorological conditions-
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridYang, L=7406279703en_HK
dc.identifier.scopusauthoridMa, S=7403723389en_HK
dc.identifier.scopusauthoridChen, PY=16303279100en_HK
dc.identifier.scopusauthoridHe, JF=25926440500en_HK
dc.identifier.scopusauthoridChan, KP=27171298000en_HK
dc.identifier.scopusauthoridChow, A=15047658600en_HK
dc.identifier.scopusauthoridOu, CQ=14070561800en_HK
dc.identifier.scopusauthoridDeng, AP=54681823000en_HK
dc.identifier.scopusauthoridHedley, AJ=7102584095en_HK
dc.identifier.scopusauthoridWong, CM=7404954904en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.citeulike9833371-

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